bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
Regeneration and homeostatic turnover of solid tissues depend on the proliferation symmetrically dividing adult stem cells, which either remain cells or differentiate based their niche position. Here we demonstrate that in zebrafish lateral line sensory organs, progenitor cell are independently regulated by two
Language: Английский
Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 111, P. 60 - 75
Published: Feb. 26, 2025
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 27, 2025
Clear cell renal carcinoma (ccRCC) is a prevalent urogenital malignancy characterized by heterogeneous patterns. Stemness pivotal factor in tumor progression, recurrence, and metastasis. Nevertheless, the impact of stemness-related long non-coding RNAs (SRlncRNAs) on prognosis ccRCC remains elusive. In this study, we aimed to delve into SRlncRNAs develop signature for risk stratification prediction. Gene-expression clinical data were downloaded from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. We calculated RNA stemness scores (RNAss) samples evaluate their stemness. mRNAs (SRmRNAs) identified through weighted correlation network analysis (WGCNA), which employed sophisticated statistical methodologies identify interconnected modules related genes. Enrichment was performed explore potential functions SRmRNAs. Multiple machine learning algorithms construct prognostic signature. Samples TCGA-KIRC GSE29609 cohorts designated as training validation cohorts, respectively. Based scores, stratified low- high-risk groups. Prognosis analysis, immune infiltration assessment, drug sensitivity prediction, mutation landscape, gene set enrichment (GSEA) conducted investigate distinct characteristics Additionally, web-based calculator developed facilitate application. effects further corroborated utilization single-cell RNA-seq (scRNA-seq), well vitro vivo experiments. SRmRNAs based RNAss WGCNA. least absolute shrinkage selection operator (LASSO) combination with multivariate Cox regression selected optimal approach. Six used groups exhibited terms prognosis, GSEA pathways, profiles, sensitivity, status. A nomogram application model. ScRNA-seq RT-qPCR demonstrated differential expression between tumors normal tissues. experiments that downregulation EMX2OS LINC00944 affected proliferation, migration, invasion, apoptosis, metastasis cells. uncovered crucial associations ccRCC. By leveraging these findings, novel SRlncRNA-related user-friendly web calculator. This holds great facilitating guiding tailored treatment strategies patients. Both confirmed role progression
Language: Английский
Citations
0
MedComm – Oncology, Journal Year: 2025, Volume and Issue: 4(2)
Published: April 8, 2025
ABSTRACT Digestive system tumor, including esophageal gastric intestinal liver pancreatic and cholangiocarcinoma, are the most common tumors worldwide serve as a major cause of tumor‐related death. Cancer stem cells (CSCs) small group in that harbor self‐renewal, differentiation abilities, playing crucial role tumor initiation, progression, metastasis, supposed to be fundamental recurrence after conventional treatment. A comprehensive understanding targeting CSCs is key overcoming tumors. In this review, focusing on digestive tumors, we summarize characteristics CSCs, review intracellular mechanisms regulate self‐renewal functional maintenance stemness pathways, transcription epigenetic regulation, metabolic noncoding RNAs, demonstrate microenvironmental regulation systemic at molecular cellular levels. Finally, recent advances therapy with CSC their niche remodeling. These research progress provide insights into occurrence, development, drug resistance, metastasis offers new targeted treatment strategies for defeating
Language: Английский
Citations
0
Experimental Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104795 - 104795
Published: April 1, 2025
Organ-specific somatic stem cells play an important role in supporting tissue turnover and facilitating regeneration upon injury. Hematopoietic are one of the most established organ-specific that have been frequently used for transplantation therapy. In recent years, there has a growing interest other cells, including vascular endothelial (VESCs). We previously reported on use CD157 CD200 as markers to isolate VESCs from adult mouse organs, particularly liver. this review, we aim summarize, based our previous research, how CD157⁺CD200⁺ liver develop fetal stage postnatal life, what transcriptional regulatory mechanisms govern them, change with aging.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156826 - 156826
Published: May 1, 2025
Language: Английский
Citations
0
Trends in cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
3
Biomedical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 100774 - 100774
Published: July 1, 2024
Asymmetric cell division (ACD) plays a pivotal role in development, tissue homeostasis, and stem maintenance. Emerging evidence suggests that long non-coding RNAs (lncRNAs) are key regulators of ACD, orchestrating the intricate molecular machinery governs fate determination. This review summarizes current literature to elucidate diverse roles lncRNAs modulating ACD across various biological contexts. The regulatory mechanisms asymmetric mediated by lncRNAs, including their interactions with protein effectors, epigenetic regulation, subcellular localization explored. Additionally, we discuss implications dysregulated mediating lead tumorigenesis. By integrating findings from experimental models types, this provides insights into multifaceted governing division, shedding light on fundamental processes. Further research area may development novel therapies targeting restore proper function. knowledge regulating could potentially revolutionize field regenerative medicine cancer therapy specific involved ACD. unraveling complex between cellular processes, potential opportunities for precision approaches be uncovered.
Language: Английский
Citations
2
Environment International, Journal Year: 2024, Volume and Issue: 191, P. 108948 - 108948
Published: Aug. 13, 2024
Bisphenol A (BPA) and its substitute fluorene-9-bisphenol (BHPF) are used in consumer products; however, their toxic effects on intestinal epithelium remain largely unknown. In this study, we combined organoids single-cell RNA sequencing to investigate the impact of BPA BHPF exposure cell composition, differentiation, function. Both compounds inhibited growth small organoids, with exhibiting a more potent inhibitory effect. did not significantly alter overall type composition; they led different alterations cell-cell communications. Gene Ontology enrichment analysis showed that exposures affected various biological processes, such as glutathione transferase activity, antioxidant lipid metabolism, type-specific compound-dependent manners. Trajectory demonstrated altered differentiation trajectory cells. To further connect cellular mechanism phenotypic vivo, constructed mouse model exposed or observed significant morphology, including reduced crypt depth villus length impaired stem proliferation self-renewal. These results provide novel insights into highlight potential risks these compounds. Our findings underscore importance evaluating safety substitutes contribute better understanding environmental chemicals gut health.
Language: Английский
Citations
2
MedComm, Journal Year: 2024, Volume and Issue: 5(11)
Published: Oct. 28, 2024
Abstract Tumor immunotherapy has significantly transformed the field of oncology over past decade. An optimal tumor would ideally elicit robust innate and adaptive immune responses within microenvironment (TIME). Unfortunately, system experiences functional decline with chronological age, a process termed “immunosenescence,” which contributes to impaired against pathogens, suboptimal vaccination outcomes, heightened vulnerability various diseases, including cancer. In this context, we will elucidate hallmarks molecular mechanisms underlying immunosenescence, detailing alterations in immunosenescence at molecular, cellular, organ, disease levels. The role tumorigenesis senescence‐related extracellular matrix (ECM) also been addressed. Recognizing that is dynamic influenced by factors, evaluate treatment strategies targeting mechanisms, as well methods for cell, organ restoration, present emerging approaches immunotherapy. overarching goal research prevent development, recurrence, metastasis, ultimately improving patient prognosis. Our review aims reveal latest advancements prospective directions research, offering theoretical basis development practical anti‐immunosenescence anti‐tumor strategies.
Language: Английский
Citations
2
The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(5)
Published: April 18, 2024
The creation of synthetic T cell states has captivated the field cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption BCOR and ZC3H12A unleashes anti-tumor cells with unprecedented lifespan killer instinct. Are we witnessing birth immortal super-soldiers in medicine?
Language: Английский
Citations
1