Circadian disruption in cancer and regulation of cancer stem cells by circadian clock genes: An updated review DOI Creative Commons
Yiling Zhang, Qiang Zhang, Rundong Liu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217391 - 217391

Published: Dec. 1, 2024

Circadian rhythm, regulated by a time keeping system termed as the circadian clock, is important for many biological processes in eukaryotes. Disordered rhythm implicated different human diseases, including cardiovascular disease, neurologic metabolic disorders, and cancer. The stem like-cancer cells (or cancer cells, CSCs) are proposed to stand at top of heterogeneous hierarchy solid tumors, which responsible tumor initiation, development, therapy resistance metastasis. Emerging evidence has shown that clock genes potentially regulate stemness features CSCs several malignant systems, leukemia, glioblastoma, breast cancer, colorectal prostate chronotherapies targeting therefore therapeutic potentials treating malignancies. In this review, we have summarized our current knowledge gene regulation normal stem/progenitor cells. Moreover, provided linking dysregulations development. Importantly, listed potential mechanisms underlying CSCs. Finally, offered attempts chronotherapy Elucidating molecular will provide us novel direction development therapeutics target

Language: Английский

Circadian clock communication during homeostasis and ageing DOI
Thomas Mortimer, Jacob G. Smith, Pura Muñoz‐Cánoves

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

2
The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies DOI Creative Commons
Jie Wang, Fanglin Shao, Qingxin Yu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

Citations

2
The central clock drives metabolic rhythms in muscle stem cells DOI Creative Commons
Valentina Sica, Jacob G. Smith, Oleg Deryagin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Summary Circadian rhythms are essential for organismal health. Satellite cells (SCs), the muscle resident stem cells, maintain a state of quiescence yet exhibit robust circadian oscillations at transcriptional level. Although peripheral clocks have been extensively studied in various tissues, how intrinsic clock interacts with central, distal is largely unknown. We used SC-specific reconstitution gene Bmal1 to elucidate role local SC and its interplay central mouse brain found that daily control metabolic processes SCs depend on input, independent clock. Central clock-driven genes were involved lipid metabolism, functionally important SC-mediated repair, autophagy was required their oscillation. In summary, we provide first evidence coordination rhythmic expression quiescent cells. Highlights Brain:satellite cell communication restores core machinery satellite Brain inputs dominant regulator transcript SCs, driving oscillation genes. Autophagy Early phases regeneration brain-driven signals.

Language: Английский

Citations

0
Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing DOI

Shujie Wu,

Shiwen Yang, Linlin Ou

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Circadian rhythm disruption, commonly caused by factors such as jet lag and shift work, is increasingly recognized a critical factor impairing wound healing. Although melatonin known to regulate circadian rhythms has potential in repair, its clinical application limited low bioavailability. To address these challenges, we developed an alginate-based dual-network hydrogel delivery system for melatonin, ensuring stable sustained release at the site. This approach enhances efficacy of modulating healing process. We investigated effects disruption on microenvironment under influence melatonin-loaded with focus biocompatibility, hemostatic properties, antioxidant response functions. Additionally, elucidated mechanisms which promotes Our findings provide insights into relationship between healing, offering promising strategy management chronic wounds associated disorders.

Language: Английский

Citations

0
Designing and Evaluating Circadian Experiments on Mouse Skin DOI Creative Commons

Junyan Duan,

Satya Swaroop Karri,

Kiarash Forouzesh

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

All skin layers and cutaneous appendages harbor a robust circadian clock, whose phase is under the influence of light through central clock in suprachiasmatic nucleus. The coordinates fundamental biological processes, including metabolism stem cell activation. It also prominently modulates activity skin-resident immune cells inflammatory response. Numerous diurnally regulated genes have been implicated diseases GWASs. Therefore, mouse powerful model for understanding diverse roles biology maintaining tissue health initiation propagation disease states. When planning experiments to study skin, multiple technical factors must be carefully considered. In this paper, we provide comprehensive guidance on general experimental design associated housing mice. We highlight importance aligning sample collection with desired hair cycle stage animal age. introduce methods disrupt altering feeding schedules as well using transgenic models. Finally, discuss use transcriptomic data, both bulk single cell, studies.

Language: Английский

Citations

0
Circadian rhythms in stem cells and their therapeutic potential DOI Creative Commons

Napasiri Putthanbut,

Pen‐Hua Su,

Jea-Young Lee

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 23, 2025

Language: Английский

Citations

0
Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice DOI Creative Commons

Ruby Chrisp,

Mary Masterson, Rebecca Pope

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 11, 2025

Abstract NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and coordinated activity between central brain peripheral liver proteins postulated to be instrumental for linking behaviour metabolism. We investigated conditional liver-specific knockout mouse model ( Npas 2-/- or cKO) explore its function in activity, rhythms cognition (novel object recognition-NOR). Circadian showed no genotype differences. Constant-light reduced NOR floxxed controls but remarkably not mice, particularly females. Consistent with entrainment systemic biology, N pas mice altered expression gene Clock frontal cortex. Sex differences independent were found genes , Bmal1 Reverb-b brain. absent mice. Females greater period length phase response constant light independently genotype. The data suggest that role light-induced memory impairment females, potential mediation by cortical expression, merit further investigation. These findings have implications interaction clocks, sex deleterious effects on cognition.

Language: Английский

Citations

0
Amplicon-based analysis reveals link between adolescent acne and altered facial skin microbiome induced by negative emotional states DOI Creative Commons
Yu Chen, Liang Peng, Yueying Li

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 19, 2025

Introduction The skin microbiome is integral to maintaining homeostasis and involved in the pathogenesis of acne. Emerging evidence supporting ‘brain-skin axis’ suggests that psychological stress may exacerbate Both negative emotional states acne are highly prevalent among adolescents. Although research has begun explore this relationship, role adolescents experiencing disturbances remains poorly understood. Methods 166 aged 15–18 were divided into four distinct groups based on their health severity: no or emotions (NC), without (NS), (YC), with (YS). Skin samples collected from each participant’s forehead analyzed using high-throughput sequencing techniques, followed by comprehensive bioinformatics analyses evaluate microbial composition diversity across different groups. Results Adolescents both exhibited significantly higher severity (IGA 2.675 ± 0.090) compared group but 1.952 0.136). Distinct community patterns emerged groups, acne-affected individuals displaying increased α-diversity. Additionally, associated heightened β-diversity differences between individuals. predominant bacterial phyla identified Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria, Acinetobacter being more abundant, Roseomonas Cutibacterium less emotions. Conclusion This study revealed biomarkers disease change when accompanied , be key contributors exacerbation. These findings underscore importance considering microbiological factors management adolescent acne, particularly within context brain-skin connection.

Language: Английский

Citations

0
The Role of the Multiplicity of Circadian Clocks in Mammalian Systems DOI
Jihwan Myung, Hélène Vitet, Vuong Truong

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: 131, P. 106518 - 106518

Published: April 10, 2025

Language: Английский

Citations

0
Exercise-mediated muscle-hypothalamus crosstalk: Improvement for cognitive dysfunction caused by disrupted circadian rhythm DOI

Ji‐Xin Shi,

Ziyuan Wang,

Sheng-wen Wang

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 373, P. 123657 - 123657

Published: April 28, 2025

Language: Английский

Citations

0