Reviving Hearts, Restoring Lives

JACC Basic to Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Stem cell therapies for spinal cord injury in humans: A review of recent clinical research

Brain and Spine, Journal Year: 2025, Volume and Issue: 5, P. 104207 - 104207

Published: Jan. 1, 2025

Recently, cell transplantation has emerged as a promising treatment for spinal cord injury (SCI). Over the past decade, numerous clinical studies of SCI have been conducted using various types cells, including fetal neural stem/progenitor cells (NS/PCs), pluripotent stem cell-derived NS/PCs, mesenchymal stem/stromal (MSCs), olfactory ensheathing and Schwann cells. Promising results reported patients with subacute SCI, especially in involving MSCs, such those Stemirac, although no universally recognized breakthroughs achieved. Allogenic NS/PCs may offer advantages over autologous MSCs because they potential engraftment within can be prepared advance, facilitating their administration during hyperacute phase. Recent advances achieved induced indicate promise to used future therapies. This review provides an overview recent discusses advancements anticipated future.

Language: Английский

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Autologous cells, no longer lost in translation

Cell stem cell, Journal Year: 2025, Volume and Issue: 32(3), P. 341 - 342

Published: March 1, 2025

Language: Английский

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GelMA/HA-NB hydrogel encapsulating adipose-derived chondrogenic exosomes enhances enthesis regeneration in chronic rotator cuff tears

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142800 - 142800

Published: April 1, 2025

Language: Английский

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Progress and challenges in developing allogeneic cell therapies

Cell stem cell, Journal Year: 2025, Volume and Issue: 32(4), P. 513 - 528

Published: April 1, 2025

The new era of cell therapeutics has started with autologous products to avoid immune rejection. However, derived from allogeneic cells could be scaled and made available for a much larger patient population if rejection reliably overcome. In this review, we outline gene engineering concepts aimed at generating immune-evasive cells. First, summarize the current state therapies, second, compile still limited data replacement therapies. We emphasize advances in fast-developing field provide an optimistic outlook future

Language: Английский

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Current Applications of Human Pluripotent Stem Cells in Neuroscience Research and Cell Transplantation Therapy for Neurological Disorders

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Language: Английский

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Demonstrated Consent and the Common Good: On Withdrawal of Consent in Stem Cell Research

The American Journal of Bioethics, Journal Year: 2025, Volume and Issue: 25(4), P. 139 - 141

Published: April 3, 2025

Language: Английский

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Scaling Up Pluripotent Stem Cell-Based Therapies: Considerations, Current Challenges & Emerging Technologies

Cytotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Clinical trials test the safety of stem-cell therapy for Parkinson’s disease

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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Evaluating teratoma formation risk of pluripotent stem cell-derived cell therapy products: a consensus recommendation from the Health and Environmental Sciences Institute’s International Cell Therapy Committee

Cytotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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