Trends in cancer, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Tumoroids are cultures of patient-derived tumor cells, which grown in 3D the presence an extracellular matrix extract and specific growth factors. can be generated from adult as well pediatric cancers, including epithelial sarcomas, brain cancers. retain multi-omic characteristics their corresponding recapitulate interpatient intratumor heterogeneity. Retrospective prospective studies have demonstrated that tumoroids predict patient responses to anticancer therapies, making them a promising tool for precision oncology. However, several challenges remain before fully integrated into clinical decision-making, success rates tumoroid establishment turnaround times. This review discusses current advances, challenges, future directions tumoroid-based models cancer research therapy.

Language: Английский