Construction of a Microenvironment‐Responsive Antibacterial Hydrogel Packed With Immunomodulatory Carbonized Polymer Dots for Periodontitis Treatment From Multiple Perspectives
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Periodontitis
is
an
increasingly
prevalent
oral
inflammatory
disease,
whose
treatment
faces
potent
challenges
because
of
recurrent
bacterial
infections,
excessive
reactive
oxygen
species
(ROS)
production,
as
well
unrelenting
inflammation‐induced
alveolar
bone
resorption
during
the
pathological
process.
Herein,
we
present
rational
design
and
construction
a
multifunctional
hydrogel
platform
composed
quaternized
chitosan/oxidized
dextran
(QCS/OD)
component
with
high
bactericidal
activity
immunomodulatory
carbonized
polymer
dots
from
resveratrol
(RSV‐CPDs)
for
periodontitis
treatment.
Such
RSV‐CPDs@QCS/OD
(RCQD)
hydrogels
exhibit
characteristics
including
shape
adaptability,
self‐healing
properties,
pH‐responsibility,
enabling
it
to
adapt
irregularly
shaped
periodontal
tissues,
degrade
gradually
in
mildly
acidic
microenvironment
periodontitis,
release
RSV‐CPDs
controlled
manner.
Significantly,
RCQD
can
effectively
suppress
proliferation
bacteria
alleviate
oxidative
stress,
relieve
inflammation
via
activating
Nrf2/NF‐κB
signaling
pathway,
ultimately
fostering
favorable
environment
regeneration
both
soft
hard
tissue.
Overall,
this
study
highlights
great
potential
treating
by
addressing
practical
needs
tissue
regeneration.
Language: Английский
Synthesis, bioactivity, and molecular docking studies: novel arylpiperazine derivatives as potential new-resistant AR antagonists
Hua Jiang,
No information about this author
Haowei Chen,
No information about this author
Ya Wang
No information about this author
et al.
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
13
Published: March 28, 2025
The
majority
of
patients
with
androgen-dependent
prostate
cancer
(PCa)
develop
resistance
to
hormone
therapy
after
approximately
18-24
months
androgen
deprivation
treatment.
During
this
process,
PCa
cells
progressively
lose
their
sensitivity
androgens
and
evolve
into
castration-resistant
leading
uncontrolled
tumor
growth
ultimately
the
failure
endocrine
therapy.
To
potential
anti-prostate
agents,
in
study,
we
identified
a
novel
ether-type
arylpiperazine
derivative
as
potent
receptor
(AR)
antagonist,
uncovering
series
effective
antiproliferative
compounds.
derivatives
(7,
11,
17,
19,
20,
21,
22,
23,
24)
demonstrated
strong
cytotoxicity
against
cells,
23
showing
significant
antagonistic
activity
(Inhibition%
>60)
robust
AR
binding
affinities.
structure-activity
relationship
(SAR)
these
developed
was
discussed
based
on
data.
Docking
study
suggested
that
compound
19
mainly
bind
ligand
pocket
site
through
Van
der
Waals'
force
interactions.
This
research
presents
promising
lead
for
developing
anticancer
agents
targeting
Language: Английский
Niclosamide as a Potential Antivirulence Agent Disrupting Quorum Sensing in Pseudomonas aeruginosa: A Molecular and In Silico Approach
Biochemical and Biophysical Research Communications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 151742 - 151742
Published: April 1, 2025
Language: Английский
Hydrothermal synthesis and characterization of carbon quantum dots from paneer whey and evaluation of their in-vitro safety, anti-oxidant and antagonistic properties
Journal of Food Measurement & Characterization,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 27, 2025
Language: Английский
Exploring rose absolute and phenylethyl alcohol as novel quorum sensing inhibitors in Pseudomonas aeruginosa and Chromobacterium violaceum
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 8, 2024
Abstract
Inter-cellular
signaling,
referred
to
as
quorum
sensing
(QS),
regulates
the
production
of
virulence
factors
in
numerous
gram-negative
bacteria,
such
human
pathogens
Pseudomonas
aeruginosa
and
Chromobacterium
violaceum
.
QS
inhibition
may
provide
an
opportunity
for
treatment
bacterial
infections.
This
represents
initial
study
examine
antibiofilm
antivirulence
capabilities
rose
absolute
its
primary
component,
phenylethyl
alcohol.
was
assessed
by
examining
extracellular
exopolysaccharide
synthesis,
biofilm
development,
swarming
motility
P.
PAO1,
along
with
violacein
C.
ATCC
12472.
Molecular
docking
analysis
conducted
explore
mechanism
which
PEA
inhibits
QS.
Our
results
indicate
that
caused
decrease
EPS
(60.5–33.5%),
(94.7–64.5%),
formation
(98.53–55.5%)
pathogen
PAO1.
Violacein
decreased
98.1%
62.5%
(0.5
v/v
%)
(2
mM).
Moreover,
molecular
revealed
a
promising
competitive
interaction
between
AHLs.
Consequently,
this
offers
valuable
insights
into
potential
inhibitors
Language: Английский
Role of fatty acids in modulating quorum sensing in Pseudomonas aeruginosa and Chromobacterium violaceum: an integrated experimental and computational analysis
Allwyn Vyas Gopalakrishnan,
No information about this author
Abinaya Kanagaraja,
No information about this author
Meenakumari Sakthivelu
No information about this author
et al.
International Microbiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 18, 2024
Language: Английский
Solvothermal Synthesis of Carbon Dots with Alkynyl Ligand for pH and Resveratrol Detection
Russian Journal of General Chemistry,
Journal Year:
2024,
Volume and Issue:
94(7), P. 1710 - 1719
Published: July 1, 2024
Language: Английский
Metal and Metal Oxide Nanoparticles: Computational Analysis of Their Interactions and Antibacterial Activities Against Pseudomonas aeruginosa
BioNanoScience,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 5, 2024
Language: Английский
Antibacterial efficacy of decorated carbon nanotubes by nano silver against pseudomonas aeruginosa
Alaa M. Khalil,
No information about this author
Menna Ali Gharieb,
No information about this author
Shokry M Abdelaty
No information about this author
et al.
Materials Research Express,
Journal Year:
2024,
Volume and Issue:
11(7), P. 075006 - 075006
Published: July 1, 2024
Abstract
Carbon
nanotubes
(CNTs)
are
considered
as
a
promising
nanomaterial
for
variety
of
applications.
It
has
desirable
physicochemical
characteristics
high
surface
area,
superior
mechanical
and
thermal
strength,
electrochemical
activity.
In
this
study,
CNTs
decorated
with
silver
nanoparticles
(AgNPs)
were
manufactured
by
an
arc
discharge
technique.
As
result,
etching
produces
stable
AgNPs-CNTs
aqueous
suspensions
pure
carbon
electrodes
in
ethanol
vapor
condensed
water.
UV-
visible
photometer,
x-ray
Diffraction,
transmission
electron
microscope,
energy
dispersive
characterized
the
synthesized
AgNPs-CNTs.
The
crystals
showed
formation
average
9.5
nm,
intermediate
length
position
about
75.8
nm
homogeneous
spherical
AgNPs
size
15.2
nm.
antibacterial
efficiency
against
Pseudomonas
aeruginosa
was
established
at
series
concentrations
(45
g
ml
−1
:
0.0879
)
while
values
MIC
MBC
determined.
levels
found
to
be
(>5.625
μ
(>11.25
g/ml)
respectively.
bacteria
cytotoxicity
evaluated
through
LDH
protein
leakage
levels.
Treated
samples
3.2
revealed
significant
injuries
cell
membrane
two
times
greater
than
treated
5.0
AgNPs.
Results
work
substantiate
synergistic
effect
combining
enhanced
properties
performance
compared
alone.
using
potential
concentration-dependent
manner.
method
can
adapted
incorporate
different
materials
or
change
synthesis
conditions,
allowing
production
tailored
specific
Language: Английский
Histological and transcriptomic insights into the interaction between grapevine and Colletotrichum viniferum
Mengru Dou,
No information about this author
Yuhang Li,
No information about this author
Yu Hao
No information about this author
et al.
Frontiers in Plant Science,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 16, 2024
Introduction
Grape
is
of
high
economic
value.
Colletotrichum
viniferum
,
a
pathogen
causing
grape
ripe
rot
and
leaf
spot,
threatens
production
quality.
Methods
This
study
investigates
the
interplay
between
C.
by
Cytological
transcriptome
sequencing.
Results
Different
grapevine
germplasms,
V.
vinifera
cv.
Thompson
Seedless
(TS),
labrusca
accession
Beaumont
(B)
piasezkii
Liuba-8
(LB-8)
were
classified
as
highly
sensitive,
moderate
resistant
to
respectively.
analysis
reveals
distinct
differences
susceptible
grapes
post-inoculation,
including
faster
development,
longer
germination
tubes,
normal
appressoria
absence
white
secretions
in
host
grapevine.
To
understand
pathogenic
mechanisms
sequencing
was
performed
on
“TS”
identifying
236
differentially
expressed
genes.
These
included
56
effectors,
36
carbohydrate
genes,
5
P450
10
genes
involved
secondary
metabolism.
Fungal
effectors
are
known
pivotal
factors
that
modulate
plant
immunity
affect
disease
development.
Agrobacterium
-mediated
transient
transformation
Nicotiana
benthamiana
screened
(CvA13877,
CvA01508,
CvA05621,
CvA00229,
CvA07043,
CvA05569,
CvA12648,
CvA02698,
CvA14071
CvA10999)
inhibited
INF1
(infestans
1,
P.
infestans
PAMP
elicitor)
induced
cell
death
2
(CvA02641
CvA11478)
death.
Additionally,
response
identified
related
hormone
signaling
(
TGA
PR1
ETR
ERF1/2
),
resveratrol
biosynthesis
STS
phenylpropanoid
PAL
COMT
photosynthetic
antenna
proteins
Lhca
Lhcb
transcription
WRKY
NAC
MYB
ERF
GATA
bHLH
SBP
ROS
(reactive
oxygen
species)
clearance
CAT
GSH
POD
SOD
disease-related
LRR
RPS2
GST
).
Discussion
highlights
potential
functional
diversity
effectors.
Our
findings
lay
foundation
for
further
research
infection
identification
targets
grape.
Language: Английский