Study on an Injectable Chitosan–Lignin/Poloxamer Hydrogel Loaded with Platelet-Rich Plasma for Intrauterine Adhesion Treatment

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 474 - 474

Published: Feb. 11, 2025

It is a great challenge to obtain an ideal hydrogel for the clinical treatment of intrauterine adhesion (IUA) disease. Here, novel injectable chitosan-lignin/poloxamer loaded with platelet-rich plasma (CL-PF127@PRP) was prepared by self-assembly at room temperature. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), rheological analysis, and writing were used characterize structure hydrogel. The results confirmed that amino group chitosan sulfonic sodium lignosulfonate ionic-crosslinked electrostatic attraction, which stabilized three-dimensional PF127 PRP, PRP made porous gradually become tight. Moreover, CL-PF127@PRP displayed good injectability solid state. soaking experiment showed had suitable degradation pH = 7 release rate (PRP 70% 96 h). Cell experiments in vitro demonstrated possessed biocompatibility, anti-inflammatory function, pro-angiogenic activity. Furthermore, animal skin wound IUA closure over 50% on seventh day. improved thickness endometrium uterus receptivity, suggesting offers promise IUA.

Language: Английский

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Application of chitosan/Nano-TiO₂/Daisy essential oil composite film for the preservation of Actinidia arguta: Inhibition of spoilage microorganisms and induction of resistance

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140893 - 140893

Published: Feb. 1, 2025

Language: Английский

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Photo-stimulating dual-network microminiature hydrogels reinforced with silver sulfide nanoparticles for regulated cancer photothermal therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161836 - 161836

Published: March 1, 2025

Language: Английский

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Enhanced biological properties of polyvinyl alcohol-polycaprolactone/hyaluronic acid-coated electrospun scaffolds for articular cartilage regeneration

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: April 23, 2025

This study provides a cohesive framework to putting forth PVA-PCL scaffolds coated with hyaluronic acid (HA) hydrogel mimic the characteristics of articular cartilage, as cost-effective tissue engineering alternative. PVA and PCL solutions were prepared electrospun under measured conditions, parameters adjusted fabricate aligned random fiber orientations. Afterward, scaffold was integrated optimal hydrogel, selected for its superior water absorption hydrophilicity. The thickness layer satisfied criteria supporting chondrocyte function, assesses effect on cell viability. Scaffolds characterized using field emission scanning electron microscopy (FE-SEM) morphology, energy-dispersive X-ray spectroscopy (EDX) elemental analysis, Fourier transform infrared (FTIR) chemical composition, tensile tests mechanical behavior. surface wettability determined by contact angle measurements. Biological properties assessed through cytotoxicity, protein assays adhesion visualization distribution DAPI staining, fluorescence microscopy, FE-SEM. Using hydrolytic mechanism, biodegradation pH variations weight loss Accordingly, randomly oriented hydrogel-coated yielded most favorable biological outcomes produce tissue-friendly, biologically robust graft that closely mimics natural cartilage extracellular matrix. pore size these more uniform than those structures. findings suggest possibilities customizing orientation, polymer blending, coating optimize response formation. Combining chondrocytes-seeded hydrogels offers way improve regeneration.

Language: Английский

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Development of Mn3O4 nanoparticles and Justicia adhatoda extract incorporated Carboxymethyl cellulose/Carbopol hydrogels: Rheological and in vitro bioactivity for sustained drug delivery system

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141713 - 141713

Published: March 1, 2025

Language: Английский

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Electrospinning-based bone tissue scaffold construction: Progress and trends

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113792 - 113792

Published: March 1, 2025

Language: Английский

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A review of polysaccharide-based hydrogels: from structural modification to biomedical applications

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143519 - 143519

Published: April 25, 2025

Language: Английский

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l-Carnosine loaded on carboxymethyl cellulose hydrogels for promoting wound healing

RSC Advances, Journal Year: 2024, Volume and Issue: 14(26), P. 18317 - 18329

Published: Jan. 1, 2024

A novel carboxymethyl cellulose hydrogel loaded with l -carnosine exhibits remarkable efficacy in enhancing the wound-healing process.

Language: Английский

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Synergistic Effects of Psidium Guajava and Copper Nanoparticles Reinforced Hybrid Hydrogel for Tissue Engineering

Advanced Industrial and Engineering Polymer Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Photothermal-Enhanced Silver Nanocluster Bioactive Glass Hydrogels for Synergistic Antimicrobial and Promote Wound Healing

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101439 - 101439

Published: Dec. 31, 2024

Language: Английский

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