Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Oct. 7, 2024
Retroperitoneal sarcoma (RPS) represents a rare and heterogeneous group of malignancies, posing significant challenges in evaluation management. Surgery, the cornerstone RPS treatment, critically depends on complete resection for favorable prognosis. The extent is crucial determinant local control survival. This review delves into evolution multidisciplinary management localized RPS, highlighting imperative to adapt surgical strategies tumor histology, location, patient functional status. We explore principles compartmental surgery—an extended first-line approach that involves resecting adjacent viscera wide negative margins—and its effectiveness across different histological subtypes more limited resections other types. Particular emphasis placed heterogeneity disease, as various exhibit distinct biological behaviors. necessitates shift away from one-size-fits-all treatment approach. analyzes role strategies, focusing type location. Additionally, potential benefits (neo)adjuvant treatments, such radiotherapy chemotherapy, are examined, recognizing their specific indications limitations. comprehensive consolidates recent data complementary therapies, advocating personalized tailored histology. As understanding molecular genetic underpinnings continues evolve, so will effective management, underscoring need global collaboration among specialists this field enhance our collective knowledge methodologies.
Language: Английский