Advances in stress-tolerance elements for microbial cell factories DOI Creative Commons

Zheyi Kuang,

Xiaofang Yan,

Yanfei Yuan

et al.

Synthetic and Systems Biotechnology, Journal Year: 2024, Volume and Issue: 9(4), P. 793 - 808

Published: June 28, 2024

Microorganisms, particularly extremophiles, have evolved multiple adaptation mechanisms to address diverse stress conditions during survival in unique environments. Their responses environmental coercion decide not only severe but are also an essential factor determining bioproduction performance. The design of robust cell factories should take the balance their growing and into account. Thus, mining redesigning stress-tolerance elements optimize performance under various extreme is necessary. Here, we reviewed several elements, including acid-tolerant saline-alkali-resistant thermotolerant antioxidant so on, providing potential materials for construction development synthetic biology. Strategies were discussed. Moreover, applications provided, perspectives discussions strategies screening made.

Language: Английский

Advances in stress-tolerance elements for microbial cell factories DOI Creative Commons

Zheyi Kuang,

Xiaofang Yan,

Yanfei Yuan

et al.

Synthetic and Systems Biotechnology, Journal Year: 2024, Volume and Issue: 9(4), P. 793 - 808

Published: June 28, 2024

Microorganisms, particularly extremophiles, have evolved multiple adaptation mechanisms to address diverse stress conditions during survival in unique environments. Their responses environmental coercion decide not only severe but are also an essential factor determining bioproduction performance. The design of robust cell factories should take the balance their growing and into account. Thus, mining redesigning stress-tolerance elements optimize performance under various extreme is necessary. Here, we reviewed several elements, including acid-tolerant saline-alkali-resistant thermotolerant antioxidant so on, providing potential materials for construction development synthetic biology. Strategies were discussed. Moreover, applications provided, perspectives discussions strategies screening made.

Language: Английский

Citations

6