Role of Quercetin Supplementation on C-reactive Protein, Tumor Necrosis Factor, and Hepcidin in Blood Transfusion-dependent Thalassemia Patients DOI Creative Commons
Raghad Abdulqader Sabri, Huda I. Al–Qadhi

Journal of Applied Hematology, Journal Year: 2024, Volume and Issue: 15(3), P. 209 - 214

Published: July 1, 2024

Abstract BACKGROUND: Transfusion-dependent thalassemia (TDT) requires regular blood transfusions, leading to iron overload, oxidative stress, and inflammation, marked by elevated tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), altered hepcidin levels. Quercetin (QC), with its antioxidant anti-inflammatory properties, shows promise in reducing these inflammatory markers regulating hepcidin, potentially alleviating TDT complications. OBJECTIVE: The objective of the study was assess role QC on patients thalassemia. PATIENTS AND METHODS: study, conducted from May December 2023, utilized a randomized controlled trial (RCT) design evaluate supplements TDT. Patients were randomly selected divided into placebo groups, samples collected analyzed. RESULTS: After 3 months supplement, group showed decrease CRP levels TNF-alpha levels, whereas exhibited an increase In addition, increased but decreased group, statistically significant differences observed between two groups ( P = 0.001). CONCLUSION: that significantly impacts overload patients, ferritin, CRP, TNF-alpha, normalizing

Language: Английский

Quercetin Alleviates Pyroptosis and Necroptosis Triggered on by DEHP Exposure in Bursa of Fabricius in Chicken by the ROS/MAPK/NF-κB Pathway DOI
Chenxi Huang, Xiaodan Wang, Wenwen Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Bis(2-ethylhexyl) phthalate (DEHP) is an endocrine disruptor that may cause damage to several species. Quercetin (Que), a common flavonoid, has anti-inflammation, antioxidation, and immune regulation properties. In this study, we identified DEHP-exposed or Que-antagonist groups in chicken MSB-1 cells explore whether Que can mitigate DEHP-caused bursa of Fabricius pyroptosis necroptosis. The findings demonstrated reduced the expression necroptosis pyroptosis, inhibited mitogen-activated protein kinase (MAPK)/NF-κB pathway, mitigated oxidative stress caused by DEHP. addition reactive oxygen species activator (Sanguinarin) raised extent stress, NF-κB (nuclear factor-kappa-B activator1, act1) activated MAPK/NF-κB pathway compared + DEHP group. conclusion, counteract DEHP-induced programmed necrosis. This work adds toxicological consequences on avian further theoretical justification for Que's treatment organic toxic damage.

Language: Английский

Citations

0
Selenium-containing peptides as effective alleviators for low-level lead induced neural damage DOI
Jiayu Zheng, Fengjiao Fan,

Wenqian Tang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 105021 - 105021

Published: Aug. 31, 2024

Language: Английский

Citations

0
Role of Quercetin Supplementation on C-reactive Protein, Tumor Necrosis Factor, and Hepcidin in Blood Transfusion-dependent Thalassemia Patients DOI Creative Commons
Raghad Abdulqader Sabri, Huda I. Al–Qadhi

Journal of Applied Hematology, Journal Year: 2024, Volume and Issue: 15(3), P. 209 - 214

Published: July 1, 2024

Abstract BACKGROUND: Transfusion-dependent thalassemia (TDT) requires regular blood transfusions, leading to iron overload, oxidative stress, and inflammation, marked by elevated tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), altered hepcidin levels. Quercetin (QC), with its antioxidant anti-inflammatory properties, shows promise in reducing these inflammatory markers regulating hepcidin, potentially alleviating TDT complications. OBJECTIVE: The objective of the study was assess role QC on patients thalassemia. PATIENTS AND METHODS: study, conducted from May December 2023, utilized a randomized controlled trial (RCT) design evaluate supplements TDT. Patients were randomly selected divided into placebo groups, samples collected analyzed. RESULTS: After 3 months supplement, group showed decrease CRP levels TNF-alpha levels, whereas exhibited an increase In addition, increased but decreased group, statistically significant differences observed between two groups ( P = 0.001). CONCLUSION: that significantly impacts overload patients, ferritin, CRP, TNF-alpha, normalizing

Language: Английский

Citations

0