Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(8)
Published: June 14, 2024
Chemotherapy is a common and effective treatment for cancer, but these drugs are also associated with significant side effects affecting patients' well-being. One such debilitating effect mucositis, characterized by inflammation, ulcerations, altered physiological functions of the gastrointestinal (GI) tract's mucosal lining. Understanding mechanisms chemotherapy-induced intestinal mucositis (CIM) crucial developing preventive measures supportive care. Chemotherapeutics not only target cancer cells rapidly dividing in GI tract. These disrupt endoplasmic reticulum (ER) homeostasis, leading to ER-stress activation unfolded protein response (UPR) various epithelial cell types. The UPR triggers signaling pathways that exacerbate tissue inflammation damage, influence differentiation fate cells, compromise integrity barrier. factors contribute significantly development progression. In this review, we aim give an in-depth overview role its impact on function. This will provide valuable insights into underlying highlighting potential therapeutic interventions could improve treatment-outcomes quality life patients.
Language: Английский