Inflammaging contributes to osteoarthritis development and human microbiota variations and vice versa: A systematic review
Osteoarthritis and Cartilage,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Language: Английский
Gallic acid mitigates lipopolysaccharide-induced testicular inflammation via regulation of the NF-κB and PK2/PKR1 pathway
Journal of Molecular Histology,
Journal Year:
2025,
Volume and Issue:
56(1)
Published: Jan. 18, 2025
Language: Английский
Gallic acid enhances honeybee larvae resistance to Paenibacillus larvae infections: Insights from molecular docking, bacterial community modulation, and whole‐genome sequencing
Insect Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Abstract
American
foulbrood
(AFB)
disease,
caused
by
the
bacterium
Paenibacillus
larvae
,
is
a
devastating
disease
affecting
honeybee
(
Apis
mellifera
L.)
populations
worldwide.
Commonly
treated
with
antibiotics,
which
have
negative
impacts
on
both
honeybees
and
environment,
there
an
urgent
need
for
alternatives
in
AFB
control.
This
study
aimed
to
investigate
effects
of
gallic
acid
(GA)
challenged
P
.
spores
explore
its
modulation
larval
microbiota.
Our
results
demonstrated
that
presence
spores,
coadministration
125
µ
g/mL
GA
significantly
increased
survival
rate
body
weight
larvae.
Molecular
docking
analyses
revealed
competitively
binds
spore
germination
proteins
YndE
GerM,
affinities
comparable
L‐tyrosine
stronger
than
uric
acid,
respectively,
suggesting
interference
germination.
16S
rRNA
gene
amplicon
sequencing
treatment
augmented
bacterial
diversity
enriched
lactic
bacteria
(LAB)
Whole‐genome
2
LAB
strains,
Apilactobacillus
kunkeei
GL‐2
Enterococcus
faecium
GL‐6,
isolated
from
GA‐treated
larvae,
unveiled
their
potential
produce
antimicrobial
secondary
metabolites
bacteriocins,
may
contribute
competitive
advantages
against
Notably,
E.
GL‐6
strain
possessed
genes
encoding
gallate
decarboxylase,
enabling
utilization,
putative
bacteriocinogenic
genetic
clusters
enterolysin
A
enterocin
L50
a/b.
These
findings
suggest
hold
as
preventive
measures
through
gut
microbiota
inhibition
P.
Language: Английский
From Traditional Efficacy to Drug Design: A Review of Astragali Radix
Xiaojie Jin,
No information about this author
Huijuan Zhang,
No information about this author
Xiaorong Xie
No information about this author
et al.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 413 - 413
Published: March 14, 2025
Astragali
Radix
(AR),
a
traditional
Chinese
herbal
medicine,
is
derived
from
the
dried
roots
of
Astragalus
membranaceus
(Fisch.)
Bge.
var.
mongholicus
(Bge.)
Hsiao
(A.
mongholicus,
AMM)
or
Bge
membranaceus,
AM).
According
to
medicine
(TCM)
theory,
AR
believed
tonify
qi,
elevate
yang,
consolidate
body’s
surface
reduce
sweating,
promote
diuresis
and
swelling,
generate
body
fluids,
nourish
blood.
It
has
been
widely
used
treat
general
weakness
chronic
illnesses
improve
overall
vitality.
Extensive
research
identified
various
medicinal
properties
AR,
including
anti-tumor,
antioxidant,
cardiovascular-protective,
immunomodulatory,
anti-inflammatory,
anti-diabetic,
neuroprotective
effects.
With
advancements
in
technology,
methods
such
as
computer-aided
drug
design
(CADD)
artificial
intelligence
(AI)
are
increasingly
being
applied
development
TCM.
This
review
summarizes
progress
on
over
past
decades,
providing
comprehensive
overview
its
efficacy,
botanical
characteristics,
distribution,
chemical
constituents,
phytochemistry.
aims
enhance
researchers’
understanding
pharmaceutical
potential,
thereby
facilitating
further
utilization.
Language: Английский
A novel Co/Zn-ferrite molecularly imprinted polymer-based electrochemical assay for sensing of gallic acid in plant extracts, wine, and herbal supplement
Analytical and Bioanalytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 5, 2024
Language: Английский
In vitro study of the treatment of dentin hypersensitivity with gallic acid combined with sodium fluoride
Xiao Han,
No information about this author
Wei Zheng,
No information about this author
Jinping Zhao
No information about this author
et al.
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 30, 2024
Dentin
hypersensitivity
(DH)
is
a
common
oral
condition
that
associated
with
severe
dental
pain.
Pain
relief
key
focus
of
the
treatment
DH.
The
purpose
this
study
was
to
evaluate
blocking
and
antacid
effects
gallic
acid
(GA)
combined
sodium
fluoride
(NaF)
on
dentinal
tubules
in
vitro.
Language: Английский