Wearable Microneedle-Based Array Patches for Continuous Electrochemical Monitoring and Drug Delivery: Toward a Closed-Loop System for Methotrexate Treatment

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(11), P. 4161 - 4170

Published: Oct. 19, 2023

Wearable devices based on microneedle (MN) technology have recently emerged as tools for in situ transdermal sensing or delivery interstitial fluid (ISF). Particularly, MN-based electrochemical sensors allow the continuous monitoring of analytes a minimally invasive manner through ISF. Exogenous small molecules found ISF such therapeutic drugs are ideal candidates MN due to their correlation with blood levels and relevance optimal management personalized therapies. Herein, hollow array patch is modified conductive pastes functionalized cross-linked chitosan develop an voltammetric sensor methotrexate (MTX). Interestingly, coating avoids biofouling while enabling adsorption MTX at electrode's surface sensitive analysis. The exhibits excellent analytical performance vitro protein-enriched artificial ex vivo under Franz diffusion cell configuration. shows linear range from 25 400 μM, which fits within high-dose treatment cancer patients operation more than two days. Moreover, iontophoretic developed integration both anode cathode single patch. characterization demonstrates on-demand drug MTX. Overall, combination patches represents impactful progress closed-loop systems disorders cancer, rheumatoid arthritis, psoriasis.

Language: Английский

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Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: unknown

Published: March 13, 2023

Maintaining the concentrations of various ions in body fluids is critical to all living organisms. In this contribution, we designed a flexible microneedle patch coupled electrode array (MNP-EA) for situ multiplexed detection ion species (Na+, K+, Ca2+, and H+) tissue interstitial fluid (ISF). The microneedles (MNs) are mechanically robust skin or cuticle penetration (0.21 N/needle) highly swellable quickly extract sufficient ISF onto ion-selective electrochemical electrodes (∼6.87 μL/needle 5 min). potentiometric sensor can simultaneously detect these with nearly Nernstian response ranges wider enough diagnosis purposes (Na+: 0.75-200 mM, K+: 1-128 Ca2+: 0.25-4.25 pH: 5.5-8.5). vivo experiments on mice, humans, plants demonstrate feasibility MNP-EA timely convenient imbalances minimal invasiveness. This transdermal sensing platform shall be instrumental home-based health monitoring chronic diseases also promising smart agriculture study plant biology.

Language: Английский

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Transdermal on-demand drug delivery based on an iontophoretic hollow microneedle array system

Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(9), P. 2304 - 2315

Published: Jan. 1, 2023

A fully integrated hollow microneedle array based iontophoretic system has been designed for on-demand drug delivery of model drugs and tested in vitro ex vivo porcine skin.

Language: Английский

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Microneedle coupled epidermal sensor for multiplexed electrochemical detection of kidney disease biomarkers

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 237, P. 115506 - 115506

Published: July 7, 2023

Language: Английский

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Swellable colorimetric microneedles for glucose detection based on glucose oxidase-like gold nanoparticles

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1288, P. 342152 - 342152

Published: Dec. 16, 2023

Language: Английский

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