RBD-Modified Polyaniline-Based Label-Free Immunosensor for Sensitive Impedimetric Detection of Anti-SARS-CoV-2 Antibodies DOI Creative Commons

Tea Romih,

Nikola Tasić,

Lea Bibič

et al.

Chemosensors, Journal Year: 2023, Volume and Issue: 11(4), P. 222 - 222

Published: April 4, 2023

The emergence of the SARS-CoV-2 virus and associated pandemic has affected entire human population. Human susceptibility to highlighted a tremendous need for affordable diagnostic systems manage monitor effectiveness vaccination. We have developed simple label-free electrochemical immunosensor detection anti-SARS-CoV-2 IgG antibodies, which consists supporting screen-printed carbon electrode (SPCE) modified with an electrodeposited polyaniline film glutaraldehyde, allowing effective immobilization spike glycoprotein receptor-binding domain (RBD) as biorecognition element. impedimetric showed linear response over wide concentration range 0.01–10 μg mL−1, that is, 67 pM–6.7 nM, low limit 25.9 pM. A dual working configuration built-in negative control unit was demonstrated practical field applications. successfully used in real serum sample from infected patient good reproducibility fair agreement ELISA. An optional amplification step secondary goat anti-human antibodies demonstrated, resulting extended 0.93

Language: Английский

Recent advances in the application of clay-containing hydrogels for hemostasis and wound healing DOI
Xiaojuan Huang, Bin Hu, Xinyuan Zhang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(3), P. 457 - 477

Published: March 3, 2024

Introduction Immediate control of bleeding and anti-infection play important roles in wound management. Multiple organ dysfunction syndrome death may occur if persistent bleeding, hemodynamic instability, hypoxemia are not addressed. The combination clay hydrogel provides a new outlet for hemostasis. In this review, the current research progress hydrogel/clay composite hemostatic agents was reviewed.

Language: Английский

Citations

23

Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment DOI
Shahzad Ahmed, Arshiya Ansari, Moin Ali Siddiqui

et al.

Advances in Natural Sciences Nanoscience and Nanotechnology, Journal Year: 2023, Volume and Issue: 14(3), P. 033001 - 033001

Published: Aug. 17, 2023

Abstract A critical step in the process for preventing and identifying emergencies relating to health, safety, welfare is testing quick diagnosis of microbial pathogens. Due fast spread waterborne food borne infections society high costs associated with them, pathogen identification has emerged as one most difficult parts water sectors. Since turn century, pathogens have demonstrated enormous epidemiological pandemic potential. The emergence dissemination a novel virus potential endanger livelihoods well-being individuals worldwide. severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) coronavirus propagated almost every country on Earth had considerable negative influence economies communities. Despite improvements techniques viral diseases, all nations must now execute biosensing speedy, sensitive, focused, consistent manner order address pressing global issues. Hence, this review, we critically summarised recent advancement electrochemical well optical biosensors monitoring SARS-COV-2 various Then, began by providing technical overview cutting-edge strategies utilised combat diseases it, including utilisation point-of-care technology (POCT), artificial intelligence (AI), internet medical things (IoMT). This review article explores integration POC, IoMT, AI technologies context personal healthcare, focusing their expedite treatment conditions, ultimately leading improved patient outcomes. Subsequently, notion execution multiplex are presented enhance comprehension detecting multiple analytes. Finally, conclusions future directions been presented.

Language: Английский

Citations

41

Review of paper-based microfluidic analytical devices for in-field testing of pathogens DOI Creative Commons
Wenliang Li,

Xuanye Ma,

Yang‐Chun Yong

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1278, P. 341614 - 341614

Published: July 11, 2023

Pathogens cause various infectious diseases and high morbidity mortality which is a global public health threat. The highly sensitive specific detection of significant importance for the effective treatment intervention to minimise impact. However, conventional methods including culture molecular method gravely depend on expensive equipment well-trained skilled personnel, limiting in laboratory. It remains challenging adapt resource-limiting areas, e.g., low middle-income countries (LMICs). To this end, low-cost, rapid, tools with capability field testing portable device identification quantification pathogens, has attracted increasing attentions. Recently, paper-based microfluidic analytical devices (μPADs) have shown promising tool rapid on-site diagnosis, providing cost-effective approach pathogens detection. fast turn-round data collection may also contribute better understanding risks insights mitigation method. In paper, critical developments μPADs in-field both clinical diagnostics environmental surveillance are reviewed. future development, challenges onsite discussed, using cross-disciplinary development with, emerging techniques such as deep learning Internet Things (IoT).

Language: Английский

Citations

36

Advancement in Paper-Based Electrochemical Biosensing and Emerging Diagnostic Methods DOI Creative Commons
Stephen Rathinaraj Benjamin, Fábio de Lima, Valter Aragão do Nascimento

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(7), P. 689 - 689

Published: June 28, 2023

The utilization of electrochemical detection techniques in paper-based analytical devices (PADs) has revolutionized point-of-care (POC) testing, enabling the precise and discerning measurement a diverse array (bio)chemical analytes. application sensing paper as suitable substrate for testing platforms led to emergence (ePADs). inherent advantages these modified have gained significant recognition POC field. In response, biosensors assembled from materials shown great promise enhancing sensitivity improving their range use. addition, numerous advantageous characteristics, including self-sufficient conveyance liquids, reduced resistance, minimal fabrication cost, environmental friendliness. This study seeks provide concise summary present state uses ePADs with insightful commentary on practicality Future developments include developing novel systems, system performance biocatalyst, combining biosensor other cutting-edge tools such machine learning 3D printing.

Language: Английский

Citations

33

Nano-engineered paper-based electrochemical biosensors: Versatile diagnostic tools for biomarker detection DOI

R. Manikandan,

Hyeon-Geun Jang,

Chang-Seok Kim

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216261 - 216261

Published: Oct. 8, 2024

Language: Английский

Citations

12

Label-free electrochemical aptasensor based on cellulose nanocrystal-modified paper-based device for Salmonella Typhimurium detection in food samples DOI

Sakda Jampasa,

Naruemon Sangthong,

Tuğba Özer

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: 211, P. 113144 - 113144

Published: Feb. 25, 2025

Language: Английский

Citations

2

Graphene-Based Electrochemical Nano-Biosensors for Detection of SARS-CoV-2 DOI Creative Commons
Joydip Sengupta, Chaudhery Mustansar Hussain

Inorganics, Journal Year: 2023, Volume and Issue: 11(5), P. 197 - 197

Published: May 1, 2023

COVID-19, a viral respiratory illness, is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), which was first identified in Wuhan, China, 2019 and rapidly spread worldwide. Testing isolation were essential to control the virus’s transmission due severity of disease. In this context, there global interest feasibility employing nano-biosensors, especially those using graphene as key material, for real-time detection virus. The exceptional properties outstanding performance nano-biosensors identifying various viruses prompted check on technology. This paper focuses recent advances graphene-based electrochemical biosensors sensing SARS-CoV-2 Specifically, it reviews types biosensors, including amperometric, potentiometric, impedimetric discusses current challenges associated with detection. conclusion review future directions field detection, underscoring importance continued research development domain.

Language: Английский

Citations

20

Smart and emerging point of care electrochemical sensors based on nanomaterials for SARS-CoV-2 virus detection: Towards designing a future rapid diagnostic tool DOI

Pattan S. Ganesh,

Saheed E. Elugoke, Seok‐Han Lee

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 352, P. 141269 - 141269

Published: Jan. 31, 2024

Language: Английский

Citations

9

A review of smart electrochemical devices for pesticide detection in agricultural food and runoff contaminants DOI
Raja Nehru, Chiu‐Wen Chen,

Cheng–Di Dong

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 935, P. 173360 - 173360

Published: May 20, 2024

Language: Английский

Citations

9

Decentralized electrochemical biosensors for biomedical applications: From lab to home DOI Creative Commons
Pramod K. Kalambate, Vipin Kumar,

Dhanjai Dhanjai

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 7, P. 100128 - 100128

Published: Jan. 1, 2025

Language: Английский

Citations

1