Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen DOI Creative Commons
Wenwen Yang, Yueqi Wang, Hongzheng Li

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 213 - 213

Published: March 25, 2024

The fibrosis process after myocardial infarction (MI) results in a decline cardiac function due to fibrotic collagen deposition and contrast agents’ metabolic disorders, posing significant challenge conventional imaging strategies making heart damage clear the microenvironment. To address this issue, we developed an strategy. Specifically, pretreated with collagenase I combined human serum albumin (HSA-C) subsequently visualized site of injury by near-infrared (NIR) fluorescence using optical agent (CI, CRT-indocyanine green) targeting transferrin receptor 1 peptides (CRT). key point strategy is that pretreatment HSA-C can reduce background signal interference tissue while enhancing CI uptake at lesion site, boundary between injured normal myocardium clearer. Our showed compared untargeted group, normalized intensity detected NIR targeted group increased 1.28-fold. 1.21-fold groups. These data demonstrate feasibility applying agents TfR1 identify ferroptosis sites injury, its clinical value management patients MI needs further study.

Language: Английский

Insight into Iron, Oxidative Stress and Ferroptosis: Therapy Targets for Approaching Anticancer Strategies DOI Open Access
Marialuisa Piccolo, Maria Grazia Ferraro,

Federica Iazzetti

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(6), P. 1220 - 1220

Published: March 20, 2024

Based on the multifaceted molecular machinery that tightly controls iron cellular homeostasis, this review delves into its paradoxical, potentially dangerous role in biological systems, with a special focus double-edged sword correlations cancer. Indeed, though is vital micronutrient and required cofactor participating several essential cell functions, tendency to cause oxidative stress can be related both cancer risk activation of death pathways. In scenario, ferroptosis refers an iron-dependent form regulated (RCD) powered by overload lethal peroxides sharing distinctive oxidized phospholipid profiles. As unique pathway, morphologically mechanistically different from other types programmed involving executioner family proteins. The accumulation cytotoxic lipid encompasses antagonism between execution defense occurring when ferroptosis-promoting activities significantly exceed antioxidant defenses. most recent breakthroughs have aroused great consideration tumor biology, as targeting provide new tools for exploring therapeutic strategies suppression. Mutations death/survival pathway alterations, well metabolic regulations cells, including propensity generate ROS, are seen features render cells unprotected ferroptosis, thereby exposing vulnerabilities which deserve further attention regarded targetable cancers limited options.

Language: Английский

Citations

12
Two novel pyrene-based Schiff base fluorescent probes for the turn-on detection of Zn2+ and their application in bioimaging DOI
Jinghua Yu,

Tongxi Jiang,

Zhi Lin

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: 209, P. 112715 - 112715

Published: Jan. 8, 2025

Language: Английский

Citations

1
Advancements in fluorescent probes for nitrite sensing: A review DOI
Qianqian Zhang, Yanjin Wang,

Ajuan Song

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1296, P. 136926 - 136926

Published: Oct. 23, 2023

Language: Английский

Citations

17
Crosstalk between autophagy and ferroptosis mediate injury in ischemic stroke by generating reactive oxygen species DOI Creative Commons
Xingyu Zhang, Pingping Han, Yining Zhao

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28959 - e28959

Published: April 1, 2024

Stroke represents a significant threat to global human health, characterized by high rates of morbidity, disability, and mortality. Predominantly, strokes are ischemic in nature. Ischemic stroke (IS) is influenced various cell death pathways, notably autophagy ferroptosis. Recent studies have increasingly highlighted the interplay between ferroptosis, process likely driven accumulation reactive oxygen species (ROS). Post-IS, either inhibition or its excessive activation can escalate ROS levels. Concurrently, interaction lipids during ferroptosis further augments accumulation. Elevated levels provoke endoplasmic reticulum stress-induced and, conjunction with free iron (Fe

Language: Английский

Citations

7
Nitrogen-doped carbon quantum dots for fluorescence sensing, anti-counterfeiting and logic gate operations DOI
Xu Li,

Yi Xian Qian,

Lei Bao

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 48(1), P. 155 - 161

Published: Nov. 21, 2023

Fluorescent nitrogen-doped CQDs were successfully fabricated for application in fluorescence sensing, anti-counterfeiting, and logic gate operations by a solvothermal method using ammonia, citric acid phloroglucinol as precursors.

Language: Английский

Citations

15
A triple-targeting fluorescent probe reveals the glutathione and viscosity crosstalk in mitochondria, endoplasmic reticulum, and nucleoli in cells during ferroptosis DOI
Lingli Wang,

Qian Xu,

Yu‐Zhong Xie

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 399, P. 134872 - 134872

Published: Oct. 30, 2023

Language: Английский

Citations

12
Unraveling Ferroptosis Mechanisms: Tracking Cellular Viscosity with Small Molecular Fluorescent Probes DOI
Niharika Pareek,

Sana Mendiratta,

Nripankar Kalita

et al.

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(8)

Published: March 2, 2024

Ferroptosis is a recently identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Numerous functions for ferroptosis have been in physiological as well pathological processes, most notably the treatment cancer. The intricate balance redox homeostasis profoundly altered during ferroptosis, leading to alteration cellular microenvironment. One such microenvironment viscosity among others pH, polarity, temperature. Therefore, understanding dynamics associated levels within organelles crucial. To date, there are very few reviews that detects assessing reactive species. In this review, we summarized organelle's specific fluorescent probes microviscosity ferroptosis. Also, offer readers an insight their design strategy, photophysics bioimaging concluding with future perspective challenges related field.

Language: Английский

Citations

4
Detecting labile heme and ferroptosis through ‘turn-on’ fluorescence and lipid droplet localization post Fe2+ sensing DOI
Yogesh Dubey, Shabnam Mansuri, Sriram Kanvah

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(20), P. 4962 - 4974

Published: Jan. 1, 2024

Development of fluorescent probes enables the sensitive detection Fe 2+ at nanomolar levels with guided lipid droplet imaging is discussed.

Language: Английский

Citations

4
Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe DOI Creative Commons
Runsha Xiao, Fan Zheng,

Kuo Kang

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Abstract Background Colorectal cancer (CRC) is a prominent global with high mortality rates among human beings. Efficient diagnosis and treatment have always been challenge for CRC management. Fluorescence guided therapy, which combines therapy into one platform, has brought new chance achieving precise theranostics. Among this, photosensitizers, applied in photodynamic (PDT), given the integration of real-time imaging capacity efficacious feasibility, show great potential to serve as remarkable tools. Although much effort put constructing photosensitizers locating destroying cells, it still need develop novel attain specific detection fulfil effective therapy. Methods Probe HTI was rational synthesized CRC. Spectrometric determination carried out first, followed by 1 O 2 generation ability test. Then, displayed distinguishing cells from normal Further, PDT effect photosensitizer studied vitro. Additionally, used BALB/c nude mice model validate its viscosity labelling tumor suppression characteristics. Results We successfully fabricated mitochondrial targeting probe, HTI, together sensitivity, ultralow background interference, excellent capacity. favorably detection, displaying 11-fold fluorescent intensity enhancement solvents 1.57 cp 2043 cp. demonstrated that could distinguish upon difference viscosity. Moreover, qualified producing efficiency supported sparkling signals DCFH after incubation under light irradiation. More importantly, performance CDX determined, enriching multifunctional validation vivo. Conclusions In this study, sensitive response possess Both vitro cell vivo trials proved effectively served robust scaffold labeling clearance. This breakthrough discovery held immense advancing early management through PDT. By leveraging HTI's properties, medical professionals benefit improved diagnostic accuracy targeted management, ultimately leading enhanced patient outcomes.

Language: Английский

Citations

8
Genipin inhibits proliferation of gastric cancer cells by inducing ferroptosis: an integrated study of network pharmacology and bioinformatics study DOI

Yalu Mi,

Hui Shan, Bo Wang

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 4, 2024

Language: Английский

Citations

2