Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen DOI Creative Commons
Wenwen Yang, Yueqi Wang, Hongzheng Li

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 213 - 213

Published: March 25, 2024

The fibrosis process after myocardial infarction (MI) results in a decline cardiac function due to fibrotic collagen deposition and contrast agents’ metabolic disorders, posing significant challenge conventional imaging strategies making heart damage clear the microenvironment. To address this issue, we developed an strategy. Specifically, pretreated with collagenase I combined human serum albumin (HSA-C) subsequently visualized site of injury by near-infrared (NIR) fluorescence using optical agent (CI, CRT-indocyanine green) targeting transferrin receptor 1 peptides (CRT). key point strategy is that pretreatment HSA-C can reduce background signal interference tissue while enhancing CI uptake at lesion site, boundary between injured normal myocardium clearer. Our showed compared untargeted group, normalized intensity detected NIR targeted group increased 1.28-fold. 1.21-fold groups. These data demonstrate feasibility applying agents TfR1 identify ferroptosis sites injury, its clinical value management patients MI needs further study.

Language: Английский

An endoplasmic reticulum-targeting fluorescent probe for the visualization of superoxide anion (O2•−) in living cells during ferroptosis DOI
Jiale Ma, Abdul Hadi Mehmood, Ruifei Wang

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 201, P. 110570 - 110570

Published: April 16, 2024

Language: Английский

Citations

2
Mitochondria-Targetable Cyclometalated Iridium(III) Complex-Based Luminescence Probe for Monitoring and Assessing Treatment Response of Ferroptosis-Mediated Hepatic Ischemia-Reperfusion Injury DOI
Chaolong Liu,

Meichun Qin,

Lin Jiang

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Ferroptosis plays an essential role in the pathological progression of hepatic ischemia-reperfusion injury (HIRI), which is closely related to iron-dependent lipid peroxidation. Since mitochondria are thought be major site reactive oxygen species (ROS) production and iron storage, monitoring variations mitochondrial hypochlorous acid (HClO) (an important member ROS) has implications for assessment ferroptosis status, as well formulation treatment strategies HIRI. However, reliable imaging tools visualization HClO its dynamic changes ferroptosis-mediated HIRI still lacking. Herein, this work, HClO-activated near-infrared (NIR) cyclometalated iridium(III) complex-based probe, named NIR-Ir-HClO, was developed visual fluxes The newly prepared probe showed fast response (<30 s), good sensitivity, excellent selectivity, cell biocompatibility, satisfactory mitochondrial-targeting performance, making it suitable accurate living cells. Moreover, inhibitors were achieved first time. All these show that NIR-Ir-HClO can utilized a tool revealing mechanism HIRI, new

Language: Английский

Citations

2
Fluorescent Determination of Glucose in Human Perspiration Using a Sensing Platform Composed of CdTe Quantum Dots (QDs) with a Zeolitic Imidazolate Framework (ZIF-8) (QD@ZIF-8) DOI
Lei Kang, Ke Wang

Analytical Letters, Journal Year: 2024, Volume and Issue: 57(18), P. 3079 - 3087

Published: Feb. 6, 2024

In sports, noninvasive analysis and monitoring of the human health condition are important to ensure well-being sportsperson prevent injuries. Multiple biomarker-related substances in body fluids can serve as physiological information or status indicators detect possible dangers athlete. As glucose content perspiration may vary with gender parts body, it is develop a highly sensitive selective detection method. Here, CdTe quantum dots (QDs) wrapped zeolitic imidazolate framework (ZIF-8) create fluorescence sensor platform (QD@ZIF-8), which successfully employed for determination levels perspiration. The synthesis QD@ZIF-8 quickly easily achieved at room temperature through one-step process. resulting exhibits strong fluorescence, emitting wavelength 587 nm when excited 360 nm. application ZIF-8 transition layer envelope QDs effectively provide chemical thermal stability, excellent dispersibility, size selectivity. utilized measure diverse group male female subjects, revealing significant differences concentrations.

Language: Английский

Citations

1
A glutathione-activatable near-infrared fluorescent probe with a large Stokes shift for imaging 4T1 tumor and its ferroptosis DOI
Lijuan Han,

Shi-Peng Wu,

Jin-He Yang

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111658 - 111658

Published: Sept. 16, 2024

Language: Английский

Citations

1
A Near-Infrared Colorimetric Fluorescent Probe for Ferrous Ion Detection and Imaging DOI

Sheng-Nan Suo,

Yang Tian,

Wei-Lun Tan

et al.

Journal of Fluorescence, Journal Year: 2023, Volume and Issue: 34(4), P. 1545 - 1550

Published: July 28, 2023

Language: Английский

Citations

3
Design and synthesis of a novel fluorescent probe for the detection of bisulfite in plant and zebrafish DOI
Fei Luo,

Yuhang Ji,

Shiyi Zhang

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1297, P. 136971 - 136971

Published: Nov. 1, 2023

Language: Английский

Citations

3
Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen DOI Creative Commons
Wenwen Yang, Yueqi Wang, Hongzheng Li

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 213 - 213

Published: March 25, 2024

The fibrosis process after myocardial infarction (MI) results in a decline cardiac function due to fibrotic collagen deposition and contrast agents’ metabolic disorders, posing significant challenge conventional imaging strategies making heart damage clear the microenvironment. To address this issue, we developed an strategy. Specifically, pretreated with collagenase I combined human serum albumin (HSA-C) subsequently visualized site of injury by near-infrared (NIR) fluorescence using optical agent (CI, CRT-indocyanine green) targeting transferrin receptor 1 peptides (CRT). key point strategy is that pretreatment HSA-C can reduce background signal interference tissue while enhancing CI uptake at lesion site, boundary between injured normal myocardium clearer. Our showed compared untargeted group, normalized intensity detected NIR targeted group increased 1.28-fold. 1.21-fold groups. These data demonstrate feasibility applying agents TfR1 identify ferroptosis sites injury, its clinical value management patients MI needs further study.

Language: Английский

Citations

0