Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Language: Английский
Citations
0Advancing clinical biochemistry: addressing gaps and driving future innovations
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: April 8, 2025
Modern healthcare depends fundamentally on clinical biochemistry for disease diagnosis and therapeutic guidance. The discipline encounters operational constraints, including sampling inefficiencies, precision limitations, expansion difficulties. Recent advancements in established technologies, such as mass spectrometry the development of high-throughput screening point-of-care are revolutionizing industry. biosensor technology wearable monitors facilitate continuous health tracking, Artificial Intelligence (AI)/machine learning (ML) applications enhance analytical capabilities, generating predictive insights individualized treatment protocols. However, concerns regarding algorithmic bias, data privacy, lack transparency decision-making ("black box" models), over-reliance automated systems pose significant challenges that must be addressed responsible AI integration. limitations remain-substantial implementation expenses, system incompatibility issues, information security vulnerabilities intersect with ethical considerations fairness protected information. Addressing these demands coordinated efforts between clinicians, scientists, technical specialists. This review discusses current biochemistry, explicitly addressing reference intervals barriers to implementing innovative biomarkers medical settings. discussion evaluates how advanced technologies multidisciplinary collaboration can overcome constraints while identifying research priorities diagnostic accessibility better delivery.
Language: Английский
Citations
0Development and optimization of an antibody-free nucleic acid lateral flow assay (AF-NALFA) as part of a molecular toolkit for visual readout of amplified Listeria monocytogenes DNA
Methods, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0Handheld RPA-Based Molecular POCT System for Rapid, Low-Cost 8-Plexed Detection of Respiratory Pathogens at Home
Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Introducing a handheld microfluidic RPA POCT system for home use, enabling extraction-free, 8-plex respiratory pathogen detection in <25 min at just $1.4 per test.
Language: Английский
Citations
0Highly atom-economic strip for respiratory syncytial virus detection using an entropy-driven circuit-based one-stone-two-birds strategy
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137963 - 137963
Published: May 1, 2025
Language: Английский
Citations
0All-in-one detection of breast cancer-derived exosomal miRNA on a pen-based paper chip
The Analyst, Journal Year: 2024, Volume and Issue: 149(4), P. 1250 - 1261
Published: Jan. 1, 2024
An all-in-one detection strategy was proposed for the identification of breast cancer-derived exosomal miRNA-21, exhibiting high sensitivity and specificity on a pen-based paper chip.
Language: Английский
Citations
3Research progress and application exploration of typical microreactor technologies for health monitoring and disease Diagnosis/Treatment
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155938 - 155938
Published: Sept. 1, 2024
Language: Английский
Citations
3Application of recombinase polymerase amplification with lateral flow assay to pathogen point-of-care diagnosis
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 18, 2024
Since the outbreak of new coronavirus, point-of-care diagnostics based on nucleic acid testing have become a requirement for development pathogen diagnostics, which require ability to accurately, rapidly, and conveniently detect pathogens. Conventional amplification techniques no longer meet requirements detection in low-resource, low-skill environments because they specialist equipment, complex operations, long times. Therefore, recombinant polymerase (RPA) is becoming an increasingly important method today’s technology it can amplify acids 20–30 minutes at constant temperature, greatly reducing dependence equipment technicians. RPA products are primarily detected through methods such as real-time fluorescence, gel electrophoresis, lateral flow assays (LFAs), other techniques. Among these, LFAs allow rapid within visualization results, offering convenient operation low cost. combination with LFA has significant advantages holds broad application prospects (POC) particularly low-resource settings. Here, we focus principles combined LFAs, their diagnosis, main limitations, some improvements methods.
Language: Английский
Citations
3Dual lateral flow assay based on PdRu nanocages for human Papillomavirus detection
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 673, P. 893 - 900
Published: June 3, 2024
Language: Английский
Citations
2Developing portable and controllable fluorescence capillary imprinted sensor for visual detection Crohn’s disease biomarkers
Talanta, Journal Year: 2024, Volume and Issue: 278, P. 126402 - 126402
Published: June 24, 2024
Language: Английский
Citations
1