Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Abstract
Interfacial
charge‐carrier
complexation
is
a
bottleneck
problem
governing
the
gating
effect
of
organic
photoelectrochemical
transistor
(OPECT)
biosensors.
Therefore,
it
has
long
been
desired
to
enhance
OPECT
and
realize
maximum
transconductance
at
zero
bias.
In
this
study,
an
in
situ
engineered
heterojunction
nano‐enzymatic
catalytic
integration
OPECT‐colorimetric
dual‐mode
sensing
platform
developed
for
dibutyl
phthalate
detection.
Specifically,
highly
efficient
photoactive
CdIn
2
S
4
/MXene‐TiO
Z‐scheme
constructed
by
two‐step
engineering
promote
effective
separation
electron–hole
pairs
achieve
sensitive
poly(ethylene
dioxythiophene):poly(styrene
sulfonate)‐based
OPECT.
Target‐induced
rolling
circle
amplification
used
as
signal
unit,
Ag@Carbon
Sphere
(Ag─CS)
conditioning
element,
which
on
one
hand
causes
shunting
photogenerated
electrons,
leading
energy
transfer
reduced
gating.
At
same
time,
Ag─CS
acts
peroxidase‐mimicking
nanozyme
oxidize
TMB
discoloration.
Importantly,
prepared
sensor
exhibits
good
selectivity
high
sensitivity
detection
with
limit
0.08
fM
also
shows
superior
ability
real
water
bodies.
provides
ideal
choice
toxic
molecule
promising
application
environmental
monitoring
food
analysis.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Abstract
Organic
photoelectrochemical
transistor
(OPECT)
biosensor
have
become
an
advanced
bioanalytical
technology
due
to
their
superior
performance.
In
this
work,
a
novel
target‐induced
bipedal
DNA
walker‐mediated
and
2
S
3
/Ti
C
(MXene)
Schottky
junction‐gated
OPECT
aptasensor
is
developed.
The
walker
activated
by
recognition
between
the
aptamer
target,
then
moved
along
predetermined
orbital
interface,
realizing
integration
of
target
signal
amplification
detection,
thus
obtaining
higher
detection
sensitivity
shorter
duration.
To
validate
innovative
nature
bioassays,
signals
are
obtained
on
OPECT‐specific
dibutyl
phthalate
(DBP)
as
molecule
through
alkaline
phosphatase
‐mediated
ascorbic
acid
(AA)
enrichment
at
/MXene
photosensitive
gate.
AA
effectively
depleted
holes
enhanced
photoelectric
response
inhibiting
electron‐hole
pair
complexation,
effective
modulation
organic
semiconductor
poly(3,4‐ethylenedioxythiophene):poly(styrene
sulfonate).
presented
achieved
sensitive
DBP
provided
low
limit
0.18
fM
based
homogeneous,
well‐integrated
recognition.
Considering
different
toxicant
molecules,
it
expected
serve
generalized
tool
with
excellent
ACS Pharmacology & Translational Science,
Journal Year:
2025,
Volume and Issue:
8(4), P. 1028 - 1049
Published: March 12, 2025
The
development
of
precise
and
efficient
delivery
systems
is
pivotal
for
advancing
CRISPR/Cas9
gene-editing
technologies,
particularly
therapeutic
applications.
Engineered
metal-organic
frameworks
(MOFs)
have
emerged
as
a
promising
class
inorganic
nonviral
vectors,
offering
unique
advantages
such
tunable
porosity,
high
cargo-loading
capacity,
biocompatibility.
This
review
explores
the
design
application
MOF-based
nanoplatforms
tailored
targeted
components,
aiming
to
enhance
precision
efficiency.
By
incorporating
stimuli-responsive
linkers
bioactive
ligands,
these
MOFs
enable
controlled
release
payloads
at
target
site.
Comparative
discussions
demonstrate
superior
performance
over
conventional
in
terms
stability,
transfection
efficiency,
reduced
off-target
effects.
Additionally,
intracellular
trafficking
mechanisms
potential
platforms
preclinical
models
are
discussed.
These
findings
highlight
transformative
overcoming
challenges
associated
with
immunogenicity
cytotoxicity,
paving
way
their
medicine.
provides
blueprint
integration
nanotechnology
genome
editing,
frontier
systems.
