Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns DOI Creative Commons
Jagadeesh Puvvula,

Ling Song,

Karolina Zalewska

et al.

Metabolomics, Journal Year: 2025, Volume and Issue: 21(1)

Published: Jan. 25, 2025

Abstract Background Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims explore global metabolome changes EDC biomarkers at delivery. Methods included 75 pregnant individuals who delivered University of Cincinnati Hospital from 2014 2017. We measured maternal urinary paraben/phenol (12), phthalate (13), and replacements (4) samples collected during delivery visit. Global serum profiles were analyzed blood ( n = 72) newborn 63) cord Fifteen 29 excluded due low detection frequency or potential exposures hospital stay. assessed metabolome-wide associations between 14 maternal/newborn profiles. Additionally, performed enrichment analysis identify alterations in pathways. Results observed concentrations metabolites (mono-isobutyl phthalate), (mono-2-ethyl-5-carboxypentyl terephthalate, mono-2-ethyl-5-hydroxyhexyl terephthalate) phenols (bisphenol-A, bisphenol-S) metabolome, using q-value < 0.2 as a threshold. (mono-n-butyl phthalate, monobenzyl phthalate) (2,5-dichlorophenol, BPA) noted. Enrichment analyses revealed (p-gamma 0.05) amino acid, carbohydrate, lipid, glycan, vitamin, other cofactor metabolism Conclusion Maternal paraben, phenol, replacement biomarker metabolome.

Language: Английский

Liquid and gas-chromatography-mass spectrometry methods for exposome analysis DOI
Victor Castro‐Alves, Nguyễn Hoàng Anh, João Marcos G. Barbosa

et al.

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 465728 - 465728

Published: Jan. 1, 2025

Language: Английский

Citations

2
Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns DOI Creative Commons
Jagadeesh Puvvula,

Ling Song,

Karolina Zalewska

et al.

Metabolomics, Journal Year: 2025, Volume and Issue: 21(1)

Published: Jan. 25, 2025

Abstract Background Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims explore global metabolome changes EDC biomarkers at delivery. Methods included 75 pregnant individuals who delivered University of Cincinnati Hospital from 2014 2017. We measured maternal urinary paraben/phenol (12), phthalate (13), and replacements (4) samples collected during delivery visit. Global serum profiles were analyzed blood ( n = 72) newborn 63) cord Fifteen 29 excluded due low detection frequency or potential exposures hospital stay. assessed metabolome-wide associations between 14 maternal/newborn profiles. Additionally, performed enrichment analysis identify alterations in pathways. Results observed concentrations metabolites (mono-isobutyl phthalate), (mono-2-ethyl-5-carboxypentyl terephthalate, mono-2-ethyl-5-hydroxyhexyl terephthalate) phenols (bisphenol-A, bisphenol-S) metabolome, using q-value < 0.2 as a threshold. (mono-n-butyl phthalate, monobenzyl phthalate) (2,5-dichlorophenol, BPA) noted. Enrichment analyses revealed (p-gamma 0.05) amino acid, carbohydrate, lipid, glycan, vitamin, other cofactor metabolism Conclusion Maternal paraben, phenol, replacement biomarker metabolome.

Language: Английский

Citations

0