Advances in Renal Replacement Therapy: The Role of Polymethyl Methacrylate Membranes in Acute Critically Ill Patients DOI
Eleonora Balzani, Sergio Lassola, Hannah Wozniak

et al.

Blood Purification, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 17, 2025

Background: Polymethyl methacrylate (PMMA) membranes are increasingly recognized for their effectiveness in treating acute kidney injury (AKI) due to strong adsorption capabilities, particularly inflammatory mediators like β2-microglobulin and IL-6. These ensure mechanical stability chemical inertness, minimizing adverse reactions during blood filtration. Summary: In conditions such as sepsis respiratory distress syndrome (ARDS), PMMA show promising findings. sepsis, they may help reduce multiorgan failure by modulating immune responses, although further research is needed confirm routine use. For ARDS, could mitigate “cytokine storms” adsorbing key cytokines, improving oxygenation hemodynamic stability, which ICU stays reliance on ventilation. Monitoring biomarkers IL-6, TNF-α critical tracking efficacy tailoring therapy individual needs. chronic conditions, hemodialysis disease, lower oxidative stress levels, reducing complications amyloidosis. By decreasing damage, provide long-term protective benefits dialysis patients. Key Message: While these advantages notable, large-scale studies establish PMMA’s efficacy, refine treatment protocols, its broader role disease management. The potential of highlights value, but standardized clinical evidence necessary widespread adoption.

Language: Английский

Advances in Renal Replacement Therapy: The Role of Polymethyl Methacrylate Membranes in Acute Critically Ill Patients DOI
Eleonora Balzani, Sergio Lassola, Hannah Wozniak

et al.

Blood Purification, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 17, 2025

Background: Polymethyl methacrylate (PMMA) membranes are increasingly recognized for their effectiveness in treating acute kidney injury (AKI) due to strong adsorption capabilities, particularly inflammatory mediators like β2-microglobulin and IL-6. These ensure mechanical stability chemical inertness, minimizing adverse reactions during blood filtration. Summary: In conditions such as sepsis respiratory distress syndrome (ARDS), PMMA show promising findings. sepsis, they may help reduce multiorgan failure by modulating immune responses, although further research is needed confirm routine use. For ARDS, could mitigate “cytokine storms” adsorbing key cytokines, improving oxygenation hemodynamic stability, which ICU stays reliance on ventilation. Monitoring biomarkers IL-6, TNF-α critical tracking efficacy tailoring therapy individual needs. chronic conditions, hemodialysis disease, lower oxidative stress levels, reducing complications amyloidosis. By decreasing damage, provide long-term protective benefits dialysis patients. Key Message: While these advantages notable, large-scale studies establish PMMA’s efficacy, refine treatment protocols, its broader role disease management. The potential of highlights value, but standardized clinical evidence necessary widespread adoption.

Language: Английский

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