Self-Assembled of Multifunctional Fluorescent Copper-DNA Nanoflowers for Cell-Specific-Target MicroRNA Imaging

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: 8(3), P. 2592 - 2600

Published: March 5, 2025

The development of simple and versatile approaches for the fabrication DNA-based composite nanomaterials, endowed with defined morphologies specific functionalities, is paramount importance various applications. Herein, we report a approach synthesis multifunctional copper-DNA nanoflowers (Cu-DNF) that exclusively consist rolling circle polymerized (DNF) in situ synthesized concatemeric fluorescence copper nanoparticles. Through meticulous regulation assembly process, it possible to generate Cu-DNF precise sizes stable properties. obtained possesses robust biostability resist degradation by nuclease, presumably resulting from dense structure Cu-DNF. were also encoded polyvalent tandem CD63 aptamer sequences, which enhanced their binding affinity internalization efficiency into tumor cells. We demonstrate can efficiently internalize cells tracking imaging analysis intracellular microRNA. This may be beneficial creating nanomaterials technological

Language: Английский

Nanoflowers: A multifunctional nanomaterial revolutionizing medicine, environmental protection, and sustainable agriculture

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114311 - 114311

Published: March 1, 2025

Language: Английский