Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer DOI Creative Commons

Yannan Zheng,

Wenhui Zhang, Lin Xu

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 11

Published: Jan. 26, 2022

Liver cancer is the third most common cause of cancer-related death following lung and stomach cancers. As a highly lethal disease, liver diagnosed frequently in less developed countries. Natural compounds extracted from herbs, animals natural materials have been adopted by traditional Chinese medicine (TCM) practices reported to be effective development new medications for treatment diseases. It important focus on mechanisms action against hepatocellular carcinoma (HCC), particularly terms cell cycle regulation, apoptosis induction, autophagy mediation migration invasion. In this review, we characterize novel representative according their pharmacologic effects based recently published studies. The aim review summarize explore therapeutic drug targets compounds, which could accelerate discovery anticancer drugs.

Language: Английский

Regulation of microtubule dynamics, mechanics and function through the growing tip DOI
Nikita B. Gudimchuk, J. Richard McIntosh

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(12), P. 777 - 795

Published: Aug. 18, 2021

Language: Английский

Citations

224
Programmably Controllable Delivery of Metastable Ferrous Ions for Multiscale Dynamic Imaging Guided Photothermal Primed Chemodynamic Therapy DOI
Xinming Zhang, Song Lin, Feng Zhao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: March 4, 2023

Metallomodulation cell death strategies are extensively investigated for antitumor therapy, such as cuproptosis, ferroptosis, and chemodynamic therapy (CDT). Undoubtedly, the accurate specific elevation of metal ions levels in cancer cells is key to boosting their therapeutic index. Herein, a programmably controllable delivery system based on croconium dye (Croc)-ferrous ion (Fe2+ ) nanoprobes (CFNPs) developed multiscale dynamic imaging guided photothermal primed CDT. The Croc, with kinds electron-rich iron-chelating groups, can form Croc-Fe2+ complex precise stoichiometry 1:1 steadily maintain valence state Fe2+ . CFNPs achieve pH-responsive visualization release cancerous tissues under coactivation "dual-key" stimulation "acidity near-infrared (NIR) light". acidic tumor microenvironment actuates NIR fluorescence/photoacoustic properties CFNPs. Sequentially, exogenous light, enable vivo release, thus achieving CDT tumors. By leveraging technologies, complicated spatiotemporal sketched manner, domino effect pH level, effect, also revealed, endowing customized feedback panorama within disease microenvironment.

Language: Английский

Citations

67
Cytoskeleton remodeling mediated by circRNA-YBX1 phase separation suppresses the metastasis of liver cancer DOI Creative Commons
Boqiang Liu, Hao Shen, Jing He

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(30)

Published: July 17, 2023

Metastasis, especially intrahepatic, is a major challenge for hepatocellular carcinoma (HCC) treatment. Cytoskeleton remodeling has been identified as vital process mediating intrahepatic spreading. Previously, we reported that HCC tumor adhesion and invasion were modulated by circular RNA (circRNA), which emerged an important regulator of various cellular processes implicated in cancer progression. Here, uncovered nuclear circRNA, circASH2, preferentially lost tissues inhibits metastasis altering cytoskeleton structure. Tropomyosin 4 (TPM4), critical binding protein actin, turned out to be the target circASH2 was posttranscriptionally suppressed. Such regulation based on messenger (mRNA)/precursormRNA splicing degradation process. Furthermore, liquid–liquid phase separation Y-box 1 (YBX1) enhanced augments TPM4 transcripts decay. Together, our data have revealed tumor-suppressive circRNA and, more importantly, fine mechanism

Language: Английский

Citations

43
Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM DOI
Bhuvanasundar Renganathan,

A. T. Moore,

Wei-Hong Yeo

et al.

The Journal of Cell Biology, Journal Year: 2025, Volume and Issue: 224(4)

Published: March 10, 2025

Vimentin intermediate filaments (VIFs) form complex, tightly packed networks; due to this density, traditional imaging approaches cannot discern single-filament behavior. To address this, we developed and validated a sparse vimentin-SunTag labeling strategy, enabling single-particle tracking of individual VIFs providing sensitive, unbiased, quantitative method for measuring global VIF motility. Using approach, define the steady-state motility rate, showing constant ∼8% undergo directed microtubule-based motion irrespective subcellular location or local filament density. Significantly, our approach revealed uncorrelated within bundles, an observation seemingly at odds with conventional models cross-linked bundles. acquired high-resolution focused ion beam scanning electron microscopy volumes vitreously frozen cells reconstructed three-dimensional finding that they only loosely organized, semi-coherent structures from which single frequently emerge locally engage neighboring microtubules. Overall, work demonstrates dynamics organization in cellular milieu first time.

Language: Английский

Citations

2
Microcarriers in application for cartilage tissue engineering: Recent progress and challenges DOI Creative Commons
Shenglong Ding, Xin Liu,

Xi-Yuan Zhao

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 81 - 108

Published: Jan. 25, 2022

Successful regeneration of cartilage tissue at a clinical scale has been tremendous challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery, have studied broadly across wide range medical fields, especially engineering (TE). Notably, microcarrier systems provide an attractive method regulating phenotype microtissue maturations, they also serve as powerful injectable carriers are combined with new technologies regeneration. In this review, we introduced typical methods to fabricate various types microcarriers discussed appropriate materials microcarriers. Furthermore, highlighted recent progress applications general design principle Finally, summarized current challenges promising prospects microcarrier-based applications. Overall, review provides comprehensive systematic guidelines rational TE.

Language: Английский

Citations

63
Cytoskeletal control of early mammalian development DOI
Hui Yi Grace Lim, Nicolas Plachta

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(8), P. 548 - 562

Published: April 29, 2021

Language: Английский

Citations

57
Unravelling cell migration: defining movement from the cell surface DOI Creative Commons
Francisco Merino-Casallo, María José Gómez‐Benito, Silvia Hervás-Raluy

et al.

Cell Adhesion & Migration, Journal Year: 2022, Volume and Issue: 16(1), P. 25 - 64

Published: May 1, 2022

Cell motility is essential for life and development. Unfortunately, cell migration also linked to several pathological processes, such as cancer metastasis. Cells' ability migrate relies on many actors. Cells change their migratory strategy based phenotype the properties of surrounding microenvironment. is, therefore, an extremely complex phenomenon. Researchers have investigated more than a century. Recent discoveries uncovered some mysteries associated with mechanisms involved in migration, intracellular signaling mechanics. These findings involve different players, including transmembrane receptors, adhesive complexes, cytoskeletal components , nucleus, extracellular matrix. This review aims give global overview our current understanding migration.

Language: Английский

Citations

53
Engine shutdown: migrastatic strategies and prevention of metastases DOI Creative Commons
Martina Raudenská,

Kateřina Petrláková,

Tamara Juriňáková

et al.

Trends in cancer, Journal Year: 2023, Volume and Issue: 9(4), P. 293 - 308

Published: Feb. 15, 2023

Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the machinery has been shown promote metastatic dissemination, successful migrastatic therapy may reduce need for high-dose cytotoxic therapies that currently used risk dissemination. In this review we focus on anti-invasive antimetastatic hold promise treatment tumors. The best targets would be those required motility, such as ATP availability, mitochondrial metabolism, cytoskeletal dynamics contractility.

Language: Английский

Citations

34
LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features DOI Creative Commons
Elodie Villalonga, Christine Mosrin,

Thierry Normand

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(5), P. 805 - 805

Published: March 4, 2023

LIM kinase 1 (LIMK1) and 2 (LIMK2) are serine/threonine tyrosine kinases the only two members of family. They play a crucial role in regulation cytoskeleton dynamics by controlling actin filaments microtubule turnover, especially through phosphorylation cofilin, an depolymerising factor. Thus, they involved many biological processes, such as cell cycle, migration, neuronal differentiation. Consequently, also part numerous pathological mechanisms, cancer, where their involvement has been reported for few years led to development wide range inhibitors. LIMK1 LIMK2 known be Rho family GTPase signal transduction pathways, but more partners have discovered over decades, both LIMKs suspected extended various pathways. In this review, we propose consider different molecular mechanisms involving associated signalling offer better understanding variety actions within physiology physiopathology cell.

Language: Английский

Citations

27
The compass to follow: Focal adhesion turnover DOI Creative Commons
Manos Mavrakis, M. Angeles Juanes

Current Opinion in Cell Biology, Journal Year: 2023, Volume and Issue: 80, P. 102152 - 102152

Published: Feb. 1, 2023

How cells move is a fundamental biological question. The directionality of adherent migrating depends on the assembly and disassembly (turnover) focal adhesions (FAs). FAs are micron-sized actin-based structures that link to extracellular matrix. Traditionally, microtubules have been considered key triggering FA turnover. Through years, advancements in biochemistry, biophysics, bioimaging tools invaluable for many research groups unravel variety mechanisms molecular players contribute turnover, beyond microtubules. Here, we discuss recent discoveries affect dynamics organization actin cytoskeleton enable timely turnover consequently proper directed cell migration.

Language: Английский

Citations

25