Proteomic profile of the antibody diversity in circulating extracellular vesicles of lung adenocarcinoma DOI Creative Commons

Xin-fu Huang,

Lijuan Xiong, Yang Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 14, 2024

Immunoglobulin diversity encompasses B-cell receptor, T-cell and antibody diversity. Existing studies have focused more on the role of receptor in tumor immunity, while is less understood. This study examined compared blood extracellular vesicles (EVs) lung cancer patients healthy individuals using proteomics bioinformatics analyses. The results revealed that among 270 identified proteins, those involved defense mechanisms were most abundant. Most these subtypes, accounting for 50.00%. Similarly, 40 EVs differentially expressed proteins (DEPs), 29 (72.50%), with a higher proportion being subtypes (82.76%). Furthermore, 24 DEP implicated 18 immune reaction-related signaling pathways. These findings suggest human serum contain significant number from differ controls (HCs). variations may be closely associated immunity.

Language: Английский

New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes DOI Open Access
Ilaria Giusti, Celeste Caruso Bavisotto

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3395 - 3395

Published: April 4, 2025

Cell-to-cell communication plays a crucial role in many processes, both physiological and pathological assets [...].

Language: Английский

Citations

0
Tumor-microenvironment-on-a-chip: the construction and application DOI Creative Commons
Hanzheng Xu,

James J. Wen,

Jiahua Yang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 23, 2024

Currently, despite the vast amounts of time and money invested in cancer treatment, remains one primary threats to human life. The factor contributing low treatment efficacy is heterogeneity. unclear molecular mechanisms underlying tumorigenesis, coupled with complexity physiology, inability animal models accurately replicate tumor microenvironment, pose significant hurdles development novel therapies. Tumor-microenvironment-on-chip (TMOC) represents a research platform that integrates three-dimensional cell culture microfluidic systems, simulating essential components physiological traits vivo microenvironment. It offers dynamic setting within chip system study progression, potentially heralding breakthrough research. In this review, we will summarize current advancements platform, encompassing various types TMOCs their applications different cancer. From our perspective, TMOC necessitates enhanced integration tissue engineering techniques microphysiological environments before it can evolve into more refined preclinical model for

Language: Английский

Citations

3
Proteomic profile of the antibody diversity in circulating extracellular vesicles of lung adenocarcinoma DOI Creative Commons

Xin-fu Huang,

Lijuan Xiong, Yang Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 14, 2024

Immunoglobulin diversity encompasses B-cell receptor, T-cell and antibody diversity. Existing studies have focused more on the role of receptor in tumor immunity, while is less understood. This study examined compared blood extracellular vesicles (EVs) lung cancer patients healthy individuals using proteomics bioinformatics analyses. The results revealed that among 270 identified proteins, those involved defense mechanisms were most abundant. Most these subtypes, accounting for 50.00%. Similarly, 40 EVs differentially expressed proteins (DEPs), 29 (72.50%), with a higher proportion being subtypes (82.76%). Furthermore, 24 DEP implicated 18 immune reaction-related signaling pathways. These findings suggest human serum contain significant number from differ controls (HCs). variations may be closely associated immunity.

Language: Английский

Citations

0