An Overview of Chronic Kidney Disease Pathophysiology: The Impact of Gut Dysbiosis and Oral Disease

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3033 - 3033

Published: Nov. 12, 2023

Chronic kidney disease (CKD) is a severe condition and significant public health issue worldwide, carrying the burden of an increased risk cardiovascular events mortality. The traditional factors that promote onset progression CKD are cardiometabolic like hypertension diabetes, but non-traditional contributors escalating. Moreover, gut dysbiosis, inflammation, impaired immune response emerging as crucial mechanisms in pathology. microbiome exert reciprocal influence commonly referred to "the gut-kidney axis" through induction metabolic, immunological, endocrine alterations. Periodontal diseases strictly involved axis for their impact on microbiota composition metabolic immunological alterations occurring reciprocally affecting both conditions. This review aims provide overview dynamic biological interconnections between oral status, gut, renal pathophysiology, spotlighting oral-gut-kidney raising whether periodontal can be modifiers CKD. By doing so, we try offer new insights into therapeutic strategies may enhance clinical trajectory patients, ultimately advancing our quest improved patient outcomes well-being.

Language: Английский

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IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1255 - 1265

Published: Jan. 1, 2025

Macrophage responses to lipopolysaccharides (LPS) drive inflammatory diseases, such as periodontitis, with production of IL-6 and Nitric Oxide (NO). However, anti-inflammatory macrophages counter inflammation the CCL22. Interferon regulatory factor 3 (IRF3) plays a significant role in expression both NO during macrophage through Interferon-stimulated Response Elements (ISREs) promoters. To determine IRF3 LPS-induced pro- responses, we used cell line RAW264.7 modified an ISRE promoter driving secreted luciferase (RAW264.7-Lucia) assess activity response Escherichia coli Porphyromonas gingivalis LPS. For comparison, poly I:C IFN-gamma from cells deficient were also assessed. Herein, LPS P. gingivalis, significantly enhanced that was induced by E. but decreased I:C-induced activity. Moreover, deficiency depressed increased CCL22 Restoration IRF3KO RAW IL-6, restored NO, coli. Therefore, is critical factors produced responding could be target periodontitis treatment.

Language: Английский

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Study of Prediction Model and Influencing Factors for Coronary Heart Disease Based on Machine Learning

Operations Research and Fuzziology, Journal Year: 2025, Volume and Issue: 15(01), P. 310 - 320

Published: Jan. 1, 2025

Language: Английский

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Comprehensive Analysis of Orthodontic Treatment Effects on the Oral Microbiome, Metabolome, and Associated Health Indicators

International Dental Journal, Journal Year: 2025, Volume and Issue: 75(3), P. 1585 - 1598

Published: March 25, 2025

Language: Английский

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Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101711 - 101711

Published: March 27, 2025

Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that mucosal adhesion properties of hydrogels play a potential role in treatment periodontitis. The hydrogel improve contact retention time drugs periodontal pocket. Through mucosa, it interacts mucin coating surface epithelium teeth to form specific interface force. exhibits strong (adhesion strength: 5-6 N/cm2) prolonged pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH reactive oxygen species (ROS). This design overcomes limitations poor mechanical stability conventional formulations. balance oral microbiota plays an important maintaining health. Probiotics, colonizing cavity, transform infected site from environment rich inflammatory cytokines more benign environment, inhibit harmful pathogenic microorganisms, contribute overall Microenvironment sensitive perform sol gel transformation situ, accurately control when exposed various stimuli (such as temperature change, light, species, etc.). Oral probiotics anti-inflammatory are encapsulated proliferation pathogens planting mouth producing metabolites, effectively preventing treating diseases.

Language: Английский

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Clinical Study and Microbiological Analysis of Periodontopathogenic Microflora Analyzed among Children and Adolescents with Cardiovascular Diseases Compared to Group with Good General Status

Pediatric Reports, Journal Year: 2024, Volume and Issue: 16(2), P. 482 - 503

Published: June 18, 2024

Periodontal diseases, as an important part of oral pathology, present different characteristics when affecting children and adolescents or young adults. Studies have shown that adolescence childhood are closely related to a high risk periodontal disease, but the follow-up for health damage at this age has been insufficiently appreciated until now. The aim study was identify subgingival microorganisms using real-time polymerase chain reaction (PCR) in group aged 7–17 years with without cardiovascular disease. 62 subjects gingival inflammation poor hygiene divided into two groups according general condition: 31 carduivascular disease (group A) C). Subjects were examined initial consultation, state assessed plaque index (PI) (GI), samples taken from sulcus sterile paper cones determine nine microorganisms. Nine identified: Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Treponema denticola (Td), Tannerella forsythias (Tf), Prevotella intermedia (Pi), Peptostreptococcus (Micromonas) micros (Pm), Fusobacterium nucleatum (Fn), Eubacterium nodatum (En), Capnocytophaga (Cg). patients included specialist treatment program which aimed relieve inflammatory condition, remove local irritative factors, train perform proper home by primary secondary products. reevaluated 3 months after treatment, measurements PI GI microbiological determinations repeated. results showed predominance 16–17 (12.4%). Among marked inflammation, male gender predominant (58.06%). values changed considerably lower presenting condition (PI = 8.10%) compared 13.77%). After considerable changes both groups. Red, orange, purple complex found before decreased highest (140,000 (1.4 × 105)) generalized inflammation. Of pathogenic microorganisms, most common forsythia 52 red appeared only 10 treatment. remained constant diseased consistent health. Children diseases had higher prevalence manifestations. composition microbial directly influenced degree hygiene, response specialized also status. support conclusion pathogens appear multiply absence eruption permanent teeth, their action leads initiation diseases.

Language: Английский

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Characterization and functional prediction of the dental plaque microbiome in patients with alveolar clefts

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 10, 2024

Introduction Alveolar cleft (AC) is a common congenital defect in people with lip and palate (CLP). bone grafting (ABG) typically performed during adolescence, resulting the fissure remaining mouth for longer length of time. Patients AC have greater rate oral diseases such as dental caries than normal population, precise characteristics bacterial alterations caused by are unknown. Methods We recruited total 87 subjects collected plaque samples from adolescents (AAP), post-operative ABG (PAP), healthy control (CAP), young adults (AYP), (PYP), (CYP). The sequencing 16S rRNA genes was performed. Results microbial composition alveolar patients differed significantly age-matched controls. Linear discriminant analysis effect size (LEfSe) revealed that AAP enriched Neisseria, Haemophilus, Fusobacterium, Rhodococcus, Aggregatibacter, Gemella , Porphyromonas whereas AYP Capnocytophaga, Rhodococcus Actinomyces-f0332 . There were phenotypic differences facultatively anaerobic, Gram-negative, Gram-positive, oxidative stress tolerance between group according to Bugbase predictions. did not alter functional phenotype but reduced number differential genera controls at both ages. Conclusions Our study systematically characterized supragingival microbiota patients, post-alveolar matched two ages gain better understanding ecology microbiology associated clefts.

Language: Английский

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Efficacy of the Probiotic L. brevis in Counteracting the Demineralizing Process of the Tooth Enamel Surface: Results from an In Vitro Study

Biomolecules, Journal Year: 2024, Volume and Issue: 14(5), P. 605 - 605

Published: May 20, 2024

Background. Enamel plays an essential role in protecting the underlying layers of human tooth; therefore, preserving it is vital. This experimental study aimed to evaluate potential ability L. brevis counteract action a demineralizing agent on dental enamel morphology and mineral composition vitro. Methods. The sample consisted 12 healthy posterior teeth. coronal portion each tooth was subdivided into two equal parts longitudinally. specimens were randomly divided four groups: artificial saliva, suspension, (DA), DA plus brevis. Scanning electron microscopy (SEM) energy-dispersive X-ray spectroscopy (EDS) used surface micromorphology content, respectively. statistical analysis conducted using one-way ANOVA, followed by Tukey’s post hoc test. Results. SEM did not highlight significant changes microstructure brevis-treated compared control. DA-induced damage structure drastically reduced when contextually exposed probiotic. treatment with substantially weight % crucial minerals, i.e., Ca P. Notably, probiotic able reverse demineralization process, bringing P back basal levels, including Ca/P ratio. Conclusions. findings indicate that efficiently protect from caused increase resistance demineralization. Overall, confirms its efficacy preventing or counteracting carious lesions through novel mechanism protects under chemical challenge mimics caries process.

Language: Английский

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Can oral health care be a gateway to improve cardiovascular disease? A scoping review

Frontiers in Oral Health, Journal Year: 2024, Volume and Issue: 5

Published: May 22, 2024

Background Cardiovascular diseases (CVDs) are a significant cause of morbidity and mortality worldwide, resulting in high socioeconomic burden. Growing evidence has shown link between oral several chronic conditions including CVDs. The focus this review is to investigate summaries the surrounding health interventions their potential impact on reducing both risk and/or severity Methods A scoping was conducted examine for managing CVD outcomes risks. adhered Joanna Briggs Institute (JBI) framework synthesis followed reporting standards outlined by Preferred Reporting Items Systematic Reviews Meta-analysis- extension Scoping Review (PRISMA-ScR). systematic search across EBSCOhost, PubMed, Scopus databases from 2012 2024 utilized identify relevant studies. Inclusion criteria focused English language articles with sample size at least 50, evaluating outcomes. Results Out initial 2,154 studies identified search, 12 met inclusion exclusion were included final analysis. Overall, revealed that along surgical non-surgical periodontal therapy, regular hygiene care practices, toothbrushing, tongue brushing, flossing, significantly reduced cardiovascular events mortality. These patients or without baseline have decrease markers as well reduction bacterial colonization. Similarly, consistent routines, combined dental visits, associated lower heart failure Conclusion extracted suggests cleaning, re-enforcing regimes can stabilize subsequently improve progression/risks. However, limited no exists regarding therapeutic effects promotion its direct disease outcomes, warranting further investigation.

Language: Английский

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Association of oral health with all-cause and cause-specific mortality in older Chinese adults: A 14-year follow-up of the Guangzhou Biobank Cohort study

Journal of Global Health, Journal Year: 2024, Volume and Issue: 14

Published: July 5, 2024

Poor oral hygiene is associated with overall wellness, but evidence regarding associations of health all-cause mortality remain inconclusive. We aimed to examine the and cause-specific in middle-aged older Chinese adults.

Language: Английский

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