Alginate-Based hydrogels with inorganic Nanomaterials: A promising approach for wound healing and bone tissue regeneration

European Polymer Journal, Journal Year: 2024, Volume and Issue: 212, P. 113057 - 113057

Published: April 23, 2024

Language: Английский

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Antimicrobial Activity of Citrate-Coated Cerium Oxide Nanoparticles

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(4), P. 354 - 354

Published: Feb. 13, 2024

The purpose of this study was to investigate the antimicrobial activity citrate-stabilized sols cerium oxide nanoparticles at different concentrations via microbiological methods and compare effect with peroxidase nanoceria for subsequent development a regeneration-stimulating medical and/or veterinary wound-healing product providing new types action. object synthesized from aqueous solutions (III) nitrate hexahydrate citric acid (the size 3–5 nm, their aggregates were 60–130 nm). Nanoceria wide range (10−1–10−6 M) as well powder dry substance) used. Both bacterial fungal strains (Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Candida albicans, Aspergillus brasielensis) used studies. investigated across using three sequentially; studied by examining diffusion into agar, serial dilution method detect minimum inhibitory bactericidal concentrations, and, finally, gas chromatography mass-selective detection performed inhibition E. coli’s growth. To redox nanocerium, we intensity chemiluminescence in oxidation reaction luminol presence hydrogen peroxide. As result study’s use agar followed sowing, no significant evidence found. At same time, current against coli mass spectrometry, ability significantly inhibit growth reproduction microorganisms after 24 h particular, 48 incubation 10−2–10−5 M (48–95% reduction number microbes dose-dependent effect) determined optimum concentration. A reliable coated citrate established, increasing proportion concentration, confirming oxidative mechanism action nanoceria. Thus, have bacteriostatic effect, which is most pronounced 10−2–10−3 M. Unlike effects classical antiseptics, manifested 2 days increased during observation. nanomaterials, it advisable not qualitative semi-quantitative methods; rather, employment more accurate quantitative advised, chromatography–mass several incubation.

Language: Английский

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In vitro and in silico study of biosynthesized silver nanoparticles using Nigella sativa extract against SARS-CoV-2 and Candida albicans

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 405, P. 125059 - 125059

Published: May 20, 2024

Pathogens that are resistant to multiple drugs, commonly known as superbugs, including viruses and fungi, posing a significant danger human health. These superbugs responsible for causing high rates of morbidity mortality each year, the numbers continuing rise. Therefore, search potent, safe, viable alternative antimicrobial agents is imperative. In current study, rapid eco-friendly method synthesizing silver nanoparticles (AgNPs) using Nigella sativa seed extract was developed. Various characterization techniques, ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared (FTIR) X-ray diffraction (XRD), scanning electron microscopy associated with microanalysis by dispersive energy X-rays (SEM-EDX), Zeta-potential, were employed confirm formation AgNPs. Agglomerated particles spherical shape size approximately 50 nm identified in SEM images The optical bandgap AgNPs determined be 2.43 eV direct 1.87 allowable indirect band gap. study also investigated antiviral activity against XBB.1.5 SARS-CoV-2 variant assessed their Anti-Candida Assay Candida albicans. Furthermore, we conducted molecular docking studies explore interactions between Omicron receptor-binding motif (RBM). spike protein RBD binds receptor angiotensin-converting enzyme 2 (ACE2) cellular (hACE2) helps virus enter host cell. results indicated can bind RBD, potentially elucidating effects SARS-CoV-2. findings this suggest hold promise potent therapeutic applications, particularly addressing multidrug-resistant strains Candida. However, further research essential thoroughly elucidate mode action assess biosafety

Language: Английский

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Biosynthesis and biological activities of magnesium hydroxide nanoparticles using Tinospora cordifolia leaf extract

Bioprocess and Biosystems Engineering, Journal Year: 2024, Volume and Issue: 47(12), P. 2111 - 2129

Published: Sept. 16, 2024

Language: Английский

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Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review

Green Chemistry Letters and Reviews, Journal Year: 2024, Volume and Issue: 17(1)

Published: Oct. 7, 2024

Antimicrobial resistance (AMR) is the top global public health and development threat. It has led to 4·95 million deaths associated with bacterial AMR in 2019, including 1·27 attributable AMR. In addition causing death disability, it projected that by 2030, annual gross domestic product (GDP) losses due could range from US$1 trillion US$3.4 trillion. current study, bio-capped silver nanoparticles (AgNPs) showed significant antibacterial activities against both gram-positive gram-negative MDR pathogens. 2.50 μg/ml 100 mg/ml 3.8 2.5 were minimum inhibitory concentration (MIC) bactericidal (MBC) of AgNPs, while zone inhibition (ZOI) was 4 25 mm. Particle size, shape, type capping or stabilizing agent, surface charge, pH, exposure time, concentration, affect AgNPs. Cell wall membrane damage, destruction biomolecules (lipids, proteins, DNA), disruption electron transport chain, proton motive force are mechanisms action general, green-synthesised AgNPs plants bacteria (synergistic effect between natural compounds) displayed activity a wide Gram-positive Gram-negative bacteria.

Language: Английский

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Eco-friendly synthesis of CeO2 nanoparticles using Morinda citrifolia L. leaf extracts: Evaluation of structural, antibacterial, and anti-inflammatory activity

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113411 - 113411

Published: Oct. 1, 2024

Language: Английский

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Spectral Characterization of Silver Nanoparticles Biosynthesized from Lysinibacillus fusiformis and its Antibacterial Efficacy Against Multidrug-Resistant Bacteria Isolated from Chronic Wounds

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(2), P. 688 - 698

Published: April 12, 2024

Language: Английский

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Royal Jelly: A Novel Biotemplate for the Green Synthesis of Antibacterial Metal Nanoparticles

Published: Jan. 1, 2025

The application of green synthesis in nanotechnology is rapidly expanding as a safe and eco-friendly alternative to conventional methods. This study explored the potential royal jelly bio-reducing agent for synthesizing metal nanoparticles evaluated their antibacterial activity. Royal exhibited strong antioxidant activity, demonstrated by ABTS (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate)) DPPH (2,2-diphenyl-1-picrylhydrazyl) assays, comparable that Trolox. However, it showed weak effects against both Gram-positive Gram-negative bacteria. Using jelly, silver, iron, copper, zinc were synthesized, confirmed Fourier Transform Infrared Spectrometer (FTIR), ultraviolet-visible (UV-Vis), fluorescence spectroscopy, morphological analyses. significant disrupting bacterial cell walls killing bacteria, shown inhibition zone minimum inhibitory concentrations (MIC), bactericidal (MBC), scanning electron microscope (SEM) imaging. research highlights jelly's dual role reducing nanoparticle its applications.

Language: Английский

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Targeting Bacterial Spores with Metallic Nanoparticles: A Promising Alternative for Food Safety

Current Opinion in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101273 - 101273

Published: Jan. 1, 2025

Language: Английский

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Nanotechnology in food safety and preservation

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 233 - 278

Published: Jan. 1, 2025

Language: Английский

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