Synthesis of Gold Nanoparticles Using Leaf Extracts of Pterospermum Canescens and Vernonia Elaeagnifolia: Characterization, Platelet Aggregation and Cytotoxic Studies DOI

C. T. Sadiya Sherin,

Thanasekaran Jayakumar,

T. S. Anitha

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(38)

Published: Oct. 1, 2024

Abstract Gold nanoparticles are extensively used across various industries, particularly in biomedical fields, due to their high biocompatibility, stability, and low toxicity. The rising use of gold applications has increased the demand for more sustainable synthesis methods that reduce costs environmental impacts compared traditional chemical processes. This study presents a green approach utilizing leaf extracts from Pterospermum canescens Vernonia elaeagnifolia . synthesized were characterized using UV‐VIS, XRD, HRTEM‐SAED, FESEM‐EDX, XPS, FTIR analyses. These characterizations confirmed formation, size, shape, morphological features nanoparticles, as well involvement secondary plant metabolites synthesis. found be less than 50 nm with P.C AuNPs averaging 27.48 V.E 14.79 nm. particles predominantly exhibited spherical or distorted shapes. In cytotoxicity assays C6 rat glioma cells, both types demonstrated significant effects. induced apoptosis 78 % while %, confirming cytotoxic efficacy. Gene expression studies further revealed significantly upregulated caspase‐3 downregulated BCL‐2, indicating potent apoptotic response, showed similar but pronounced effect. Additionally, collagen‐induced platelet aggregation studies, substantial anti‐platelet activity increasing dosages, reducing 10 at concentration 30 μg/ml, minimal inhibition by AuNPs. Overall, demonstrates effective offer promising biomedicine. results confirm potential these green‐synthesized cancer treatment drug development

Language: Английский

Plant biomass-based nanoparticles for remediation of contaminants from water ecosystems: Recent trends, challenges, and future perspectives DOI

Divya Bhushan,

Sachin Shoran, Rakesh Kumar

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: unknown, P. 143340 - 143340

Published: Sept. 1, 2024

Language: Английский

Citations

2
Potential biological applications of environment friendly synthesized iron oxide nanoparticles using Sageretia thea root extract DOI Creative Commons

Muhammad Israeel,

Javed Iqbal, Bilal Haider Abbasi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 16, 2024

Abstract The green synthesis of Iron oxide nanoparticles (IONPs) has shown numerous advantages over conventional physical and chemical methods as these non-ecofriendly uses toxic chemicals complicated equipments. In present study, were created using simple, sustainable, eco-friendly chemistry protocol. roots novel medicinal plant Sageretia thea was used a bio-template for the preparation IONPs. Further, IONPs confirmed different analytical tools like UV-Vis, FT-IR, XRD, EDX, SEM. average sizes (NPs) found to be 16.04 nm. asynthesized evaluated several biological potentials including antibacterial, antifungal Anti-radical (DPPH) cytotoxicity assays. Antibacterial potencies investigated bacterial strains (in concentration range 1000–31.25 µg/mL) revealing significant antibacterial potentials. ABA SAU reported least susceptible while KPN observed most strain in bactericidal studies. fungal investigate revealed strong against pathogenic strains. Furthermore, MRA, FA ANI fungicidal examination. Significant potential examined brine shrimps assay, thus cytotoxic IC 50 S. based recorded 33.85 µg/mL. Strong anti-radical assay performed evaluate ROS scavenging S.T@IONPs. highest noted 78.06%, TRP 81.92% TAC 84% on maximum 200 summary, our experimental results concluded, that have antifungal, DPPH can applications. nutshell, as-prepared bioactivities we recommend, other vitro vivo further analyze

Language: Английский

Citations

2
Low-Cost Plant-Based Metal and Metal Oxide Nanoparticle Synthesis and Their Use in Optical and Electrochemical (Bio)Sensors DOI Creative Commons
Iulia Corina Ciobotaru, Daniela Oprea, Constantin Claudiu Ciobotaru

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(12), P. 1031 - 1031

Published: Dec. 15, 2023

Technological progress has led to the development of analytical tools that promise a huge socio-economic impact on our daily lives and an improved quality life for all. The use plant extract synthesized nanoparticles in fabrication optical or electrochemical (bio)sensors presents major advantages. Besides their low-cost scalability, these may have dual role, serving as transducer component recognition element, latter requiring functionalization with specific components. Different approaches, such surface modification techniques facilitate precise biomolecule attachment, thereby augmenting capabilities, fine tuning functional groups nanoparticle surfaces are preferred ensuring stable conjugation while preserving bioactivity. Size optimization, maximizing area, tailored shapes increase potential robust interactions enhance transduction. This article specifically aims illustrate adaptability effectiveness biosensing platforms identifying biological targets along far-reaching implications across various domains, spanning healthcare diagnostics, environmental monitoring, diverse bioanalytical fields. By exploring applications, highlights significance prioritizing natural resources synthesis. emphasis aligns worldwide goal envisioning sustainable customized solutions, emphasizing heightened sensitivity selectivity.

Language: Английский

Citations

5
Influence of pH on Room-Temperature Synthesis of Zinc Oxide Nanoparticles for Flexible Gas Sensor Applications DOI Creative Commons

Fazia Mechai,

Ahmad Al Shboul,

Mohand Outahar Bensidhoum

et al.

Chemosensors, Journal Year: 2024, Volume and Issue: 12(5), P. 83 - 83

Published: May 16, 2024

This research contributes to work on synthesizing zinc oxide nanoparticles (ZnO NPs) at room temperature (RT) and their utilization in flexible gas sensors. RT ZnO NP synthesis with a basicity solution (pH ≈ 13) demonstrates an efficient method for well-crystalline NPs (RT.pH13) comparable those synthesized by the hydrothermal (hyd.C). The RT.pH13 achieved high thermal stability minimal organic reside impurities (~4.2 wt%), 30–80 nm particle size distribution, specific surface area (14 m2 g−1). pre- post-calcinated were then incorporated into sensors sensing applications ambient conditions (RT relative humidity of 30–50%). pre-calcinated ZnO-based sensor demonstrated superior sensitivity styrene acetic acid lower dimethyl-6-octenal. calcinated (RT.pH13.C) exhibited acid, but heightened benzene, acetone, ethanol. suggests correlation between structural transformations following calcination. investigation mechanisms highlighted role properties sensors’ affinity molecules variations. study further explored mechanical flexibility, which is crucial Internet Things (IoT) applications.

Language: Английский

Citations

1
Synthesis of Gold Nanoparticles Using Leaf Extracts of Pterospermum Canescens and Vernonia Elaeagnifolia: Characterization, Platelet Aggregation and Cytotoxic Studies DOI

C. T. Sadiya Sherin,

Thanasekaran Jayakumar,

T. S. Anitha

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(38)

Published: Oct. 1, 2024

Abstract Gold nanoparticles are extensively used across various industries, particularly in biomedical fields, due to their high biocompatibility, stability, and low toxicity. The rising use of gold applications has increased the demand for more sustainable synthesis methods that reduce costs environmental impacts compared traditional chemical processes. This study presents a green approach utilizing leaf extracts from Pterospermum canescens Vernonia elaeagnifolia . synthesized were characterized using UV‐VIS, XRD, HRTEM‐SAED, FESEM‐EDX, XPS, FTIR analyses. These characterizations confirmed formation, size, shape, morphological features nanoparticles, as well involvement secondary plant metabolites synthesis. found be less than 50 nm with P.C AuNPs averaging 27.48 V.E 14.79 nm. particles predominantly exhibited spherical or distorted shapes. In cytotoxicity assays C6 rat glioma cells, both types demonstrated significant effects. induced apoptosis 78 % while %, confirming cytotoxic efficacy. Gene expression studies further revealed significantly upregulated caspase‐3 downregulated BCL‐2, indicating potent apoptotic response, showed similar but pronounced effect. Additionally, collagen‐induced platelet aggregation studies, substantial anti‐platelet activity increasing dosages, reducing 10 at concentration 30 μg/ml, minimal inhibition by AuNPs. Overall, demonstrates effective offer promising biomedicine. results confirm potential these green‐synthesized cancer treatment drug development

Language: Английский

Citations

1