GeroScience,
Journal Year:
2023,
Volume and Issue:
45(3), P. 2065 - 2078
Published: April 10, 2023
Abstract
Aging
is
a
major
risk
factor
for
many
chronic
diseases.
This
study
aimed
to
examine
the
effects
of
antihypertensive,
lipid-lowering,
and
antidiabetic
drugs
on
biological
aging.
We
included
672
participants
2746
repeated
measurements
from
Swedish
Adoption/Twin
Study
Aging.
Self-reported
medicine
uses
were
categorized
into
antidiabetic,
lipid-lowering
drugs.
A
total
12
biomarkers
aging
(BA
biomarkers)
as
outcomes.
Conditional
generalized
estimating
equations
applied
conditioning
individuals
estimate
drug
effect
BA
biomarker
level
within
same
person
when
using
or
not
drug.
Chronological
age,
body
mass
index,
smoking
status,
number
multiple
medication
uses,
blood
pressure,
glucose
level,
apoB/apoA
ratio
adjusted
covariates
in
model.
Overall,
antihypertensive
was
associated
with
decrease
one
DNA-methylation
age
(PCGrimAge:
beta
=
−
0.39,
95%CI
0.67
0.12).
When
looking
subcategories,
calcium
channel
blockers
(CCBs)
several
ages
(PCHorvathAge
1.28,
2.34
0.21;
PCSkin&bloodAge
1.34,
2.61
0.07;
PCPhenoAge
1.74,
2.58
0.89;
PCGrimAge
0.57,
0.96
0.17)
functional
(functional
index
2.18,
3.65
0.71;
frailty
1.31,
2.43
0.18).
However,
results
other
subcategories
inconsistent.
Calcium
may
captured
by
measured
at
epigenetic
level.
Future
studies
are
warranted
confirm
these
understand
underlying
mechanisms.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(23), P. 5760 - 5760
Published: Dec. 5, 2024
Currently,
natural
bioactive
ingredients
and/or
raw
materials
are
of
significant
interest
to
scientists
around
the
world.
Flavonoids
and
other
polyphenols
a
major
group
phytochemicals
that
have
been
researched
noted
as
molecules.
They
offer
several
pharmacological
medical
benefits.
This
current
review
aims
(1)
illustrate
their
benefits
for
human
health,
such
antioxidant,
anti-aging,
anti-cancer,
anti-inflammatory,
anti-microbial,
cardioprotective,
neuroprotective,
UV-protective
effects,
also
(2)
perform
quality
evaluation
traditional
medicines
future
application.
Consequently,
keywords
were
searched
on
Scopus,
Google
Scholar,
PubMed
so
search
related
publications.
Then,
those
publications
carefully
checked
in
order
find
non-redundant
studies
matched
objective
this
review.
According
review,
researchers
worldwide
very
interested
discovering
potential
flavonoids
polyphenols,
used
taken
from
medicinal
plants,
relation
pharmaceutical
applications.
Many
focus
health
tested
using
silico,
vitro,
vivo
models.
However,
few
carried
out
clinical
trials
trustworthy
subject
sizes
accordance
with
practice
guidelines.
Additionally,
interesting
research
directions
perspectives
highlighted
work.
Cells,
Journal Year:
2023,
Volume and Issue:
12(7), P. 998 - 998
Published: March 24, 2023
Advanced
age
is
a
shared
risk
factor
for
many
chronic
and
debilitating
skeletal
diseases
including
osteoporosis
periodontitis.
Mesenchymal
stem
cells
develop
various
aging
phenotypes
the
onset
of
senescence,
intrinsic
loss
regenerative
potential
exacerbation
inflammatory
microenvironment
via
secretory
factors.
This
review
elaborates
on
emerging
concepts
molecular
epigenetic
mechanisms
MSC
such
as
accumulation
oxidative
stress,
DNA
damage
mitochondrial
dysfunction.
Senescent
MSCs
aggravate
local
inflammation,
disrupt
bone
remodeling
bone-fat
balance,
thereby
contributing
to
progression
age-related
diseases.
Various
rejuvenation
strategies
target
senescent
could
present
promising
paradigm
restore
aging.
GeroScience,
Journal Year:
2023,
Volume and Issue:
45(3), P. 2065 - 2078
Published: April 10, 2023
Abstract
Aging
is
a
major
risk
factor
for
many
chronic
diseases.
This
study
aimed
to
examine
the
effects
of
antihypertensive,
lipid-lowering,
and
antidiabetic
drugs
on
biological
aging.
We
included
672
participants
2746
repeated
measurements
from
Swedish
Adoption/Twin
Study
Aging.
Self-reported
medicine
uses
were
categorized
into
antidiabetic,
lipid-lowering
drugs.
A
total
12
biomarkers
aging
(BA
biomarkers)
as
outcomes.
Conditional
generalized
estimating
equations
applied
conditioning
individuals
estimate
drug
effect
BA
biomarker
level
within
same
person
when
using
or
not
drug.
Chronological
age,
body
mass
index,
smoking
status,
number
multiple
medication
uses,
blood
pressure,
glucose
level,
apoB/apoA
ratio
adjusted
covariates
in
model.
Overall,
antihypertensive
was
associated
with
decrease
one
DNA-methylation
age
(PCGrimAge:
beta
=
−
0.39,
95%CI
0.67
0.12).
When
looking
subcategories,
calcium
channel
blockers
(CCBs)
several
ages
(PCHorvathAge
1.28,
2.34
0.21;
PCSkin&bloodAge
1.34,
2.61
0.07;
PCPhenoAge
1.74,
2.58
0.89;
PCGrimAge
0.57,
0.96
0.17)
functional
(functional
index
2.18,
3.65
0.71;
frailty
1.31,
2.43
0.18).
However,
results
other
subcategories
inconsistent.
Calcium
may
captured
by
measured
at
epigenetic
level.
Future
studies
are
warranted
confirm
these
understand
underlying
mechanisms.
