Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 21, 2024
Abstract
Mitochondrial
unfolded
protein
response
(UPR
mt
)
is
triggered
through
eIF2α
phosphorylation
in
mammal.
However,
the
mechanisms
of
UPR
activation
and
influence
on
mitochondrial
translation
remain
unclear.
In
this
study,
we
confirmed
that
was
a
rapid
specific
stress
with
pharmacological
induction,
along
expression
phosphorylation,
ATF4,
CHOP.
Meanwhile,
up-regulation
some
chaperones,
cytochrome
P450
enzymes,
DDIT4
determined
by
RNA-Seq
ribosome
profiling,
essential
for
expressing
ATF4
CHOP,
then
traffics
into
nucleus
initiates
CHOP
expression.
addition,
generation
ROS
morphology
unchanged
under
GTPP
induced
.
Furthermore,
unraveled
mechanism
HRI
kinase
mediates
proteins
CRISPR-Cas9
technology
recruitment
interaction
other
proteins.
number
imports
were
inhibited
accumulation
protein.
These
findings
provide
molecular
impact
cellular
translation,
which
will
offer
novel
insights
functional
research
,
including
its
implications
human
diseases
pathobiology.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 364 - 364
Published: Jan. 3, 2025
This
review
describes
our
current
understanding
of
the
role
mitochondria
in
repurposing
anti-diabetes
drugs
metformin,
gliclazide,
GLP-1
receptor
agonists,
and
SGLT2
inhibitors
for
additional
clinical
benefits
regarding
unhealthy
aging,
long
COVID,
mental
neurogenerative
disorders,
obesity.
Metformin,
most
prominent
these
diabetes
drugs,
has
been
called
“Drug
Miracles
Wonders,”
as
trials
have
found
it
to
be
beneficial
human
patients
suffering
from
maladies.
To
promote
viral
replication
all
infected
cells,
SARS-CoV-2
stimulates
liver
cells
produce
glucose
export
into
blood
stream,
which
can
cause
COVID
patients,
reduces
levels
blood,
was
shown
cut
incidence
rate
half
recovering
SARS-CoV-2.
Metformin
leads
phosphorylation
AMP-activated
protein
kinase
AMPK,
accelerates
import
via
transporter
GLUT4
switches
starvation
mode,
counteracting
virus.
Diabetes
also
stimulate
unfolded
response
thus
mitophagy,
is
healthy
aging
health.
were
mimic
exercise
help
reduce
body
weight.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1025 - 1025
Published: Feb. 24, 2025
Mitochondria,
as
vital
organelles,
play
a
central
role
in
subcellular
research
and
biomedical
innovation.
Although
functional
nucleic
acid
(FNA)
nanostructures
have
witnessed
remarkable
progress
across
numerous
biological
applications,
strategies
specifically
tailored
to
target
mitochondria
for
molecular
imaging
therapeutic
interventions
remain
scarce.
This
review
delves
into
the
latest
advancements
leveraging
FNA
mitochondria-specific
cancer
therapy.
Initially,
we
explore
creation
of
FNA-based
biosensors
localized
mitochondria,
enabling
real-time
detection
visualization
critical
molecules
essential
mitochondrial
function.
Subsequently,
examine
developments
aimed
at
mitochondrial-targeted
treatments,
including
modular
nanodevices
precise
delivery
agents
programmable
disrupting
processes.
Emphasis
is
placed
on
elucidating
chemical
principles
underlying
design
mitochondrial-specific
nanotechnology
diverse
uses.
Lastly,
address
unresolved
challenges
outline
prospective
directions,
with
goal
advancing
field
encouraging
sophisticated
tools
both
academic
inquiry
clinical
applications
centered
mitochondria.
Mitochondrion,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102040 - 102040
Published: April 1, 2025
Mitochondria
are
essential
organelles
for
cellular
function
and
have
become
a
broad
field
of
study.
In
cardio-renal
diseases,
it
has
been
established
that
mitochondrial
dysfunction
is
primary
mechanism
leading
to
these
pathologies.
Under
stress,
mitochondria
can
develop
stress
response
mechanisms
maintain
quality
control
(MQC)
functions.
contrast,
the
perturbation
associated
with
pathogenesis
several
diseases.
Thus,
targeting
specific
pathways
within
MQC
could
offer
therapeutic
avenue
protecting
integrity.
However,
related
signaling
in
axis
poorly
explored.
The
limitations
include
lack
reproducibility
experimental
models
disease,
incomplete
knowledge
molecules
generate
bidirectional
damage,
temporality
study
models.
Therefore,
we
believe
integration
all
those
limitations,
along
recent
advances
(i.e.,
mitophagy),
(e.g.,
integrated
response,
unfolded
protein
import),
pharmacology,
targeted
approaches
reveal
what
deregulation
like
provide
ideas
generating
strategies
seek
avoid
progression
Journal of Cell Science,
Journal Year:
2025,
Volume and Issue:
138(9)
Published: May 1, 2025
As
we
have
learned
more
about
mitochondria
over
the
past
decades,
including
their
essential
cellular
roles
and
how
altered
mitochondrial
biology
results
in
disease,
it
has
become
apparent
that
they
are
not
just
powerplants
pumping
out
ATP
at
whim
of
cell.
Rather,
dynamic
information
energy
processors
play
crucial
directing
dozens
processes
behaviors.
They
provide
instructions
to
enact
programs
regulate
various
operations,
such
as
complex
metabolic
networks,
signaling
innate
immunity,
even
control
cell
fate,
dictating
when
cells
should
divide,
differentiate
or
die.
To
help
current
future
generations
biologists
incorporate
dynamic,
multifaceted
nature
assimilate
modern
discoveries
into
scientific
framework,
need
a
21st
century
'rebranding'.
In
this
Opinion
article,
argue
be
considered
'Chief
Executive
Organelle'
-
CEO
Veterinary Research,
Journal Year:
2025,
Volume and Issue:
56(1)
Published: May 2, 2025
Abstract
Brucella
is
a
successful
pathogen
that
employs
plethora
of
immune
evasion
mechanisms.
This
contributes
to
pathogenesis
and
persistence
limits
the
efficacy
available
treatments.
An
increasing
understanding
host‒pathogen
interactions
suggests
integrating
host-directed
strategies
with
existing
anti-
treatments
could
lead
more
effective
bacterial
clearance
reduction
in
drug-resistant
strains.
SIRT2
nicotinamide
adenine
dinucleotide
(NAD
+
)-dependent
deacetylase
found
mammals.
It
can
deacetylate
various
transcription
factors
regulatory
proteins,
playing
crucial
roles
infection-induced
apoptosis.
In
this
study,
we
investigated
role
-induced
cell
apoptosis
using
bovine
placental
trophoblast
cells.
Our
results
indicate
B.
abortus
A19
infection
upregulates
protein
expression
significantly
induces
mitochondrial
these
Furthermore,
inhibition
exacerbates
A19-induced
markedly
inhibits
intracellular
survival.
These
prove
mechanism
action.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(3), P. 303 - 303
Published: March 4, 2024
Mitochondria
are
most
likely
descendants
of
strictly
aerobic
prokaryotes
from
the
class
Alphaproteobacteria.
The
mitochondrial
matrix
is
surrounded
by
two
membranes
according
to
its
relationship
with
Gram-negative
bacteria.
Similar
bacterial
outer
membrane,
membrane
acts
as
a
molecular
sieve
because
it
also
contains
diffusion
pores.
However,
more
actively
involved
in
metabolism
plays
functional
role,
whereas
has
only
passive
sieving
properties.
Mitochondrial
porins,
known
eukaryotic
porins
or
voltage-dependent
anion-selective
channels
(VDACs)
control
permeability
properties
membrane.
They
contrast
they
voltage-dependent.
switch
at
relatively
small
transmembrane
potentials
20
30
mV
closed
states
that
exhibit
different
than
open
state.
Whereas
state
preferentially
permeable
anionic
metabolites
metabolism,
prefer
cationic
solutes,
particular,
calcium
ions.
encoded
nucleus,
synthesized
cytoplasmatic
ribosomes,
and
post-translationally
imported
through
special
transport
systems
into
mitochondria.
Nineteen
beta
strands
form
beta-barrel
cylinders
related
porins.
pores
contain
addition
an
α-helical
structure
N-terminal
end
protein
serves
gate
for
voltage-dependence.
Similarly,
bind
peripheral
proteins
function
compartment
formation.
This
means
localized
strategic
position
metabolism.
features
role
apoptosis
cancer
will
be
discussed
this
article.
