Exploring the Nodus of Treatment, the Philosophical Status of Non-pharmacologic Treatment

International Journal of Homeopathy & Natural Medicines, Journal Year: 2025, Volume and Issue: 11(1), P. 15 - 24

Published: Feb. 20, 2025

Non-pharmacologic treatments (NPTs) based on homeopathy is being paid more and attention, but because of its lack theoretical foundation, it difficult to become the mainstream medicine. Although has a history nearly 200 years remedied shortcomings current medicine, still questioned by many people. Homeopathy actually an NPT, diluted liquid almost no medicinal component, only water in act shaking medicine bottle give people belief, patients who have effect with drug treatment benefit from treatment. Supporters believe that human body strong ability repair itself, spiritual strength occupies very important status. However, question science homeopathy, meantime also do not clarify whether scientific. High morbidity mortality are indisputable realities, careful analysis medical research theory, reason why cannot be good guide practice, withstand scrutiny philosophical deviated correct law thinking. There should place for NPTs needs supported theories principles. support theories.

Language: Английский

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From Physiology to Psychiatry: Key role of vagal interoceptive pathways in emotional control

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Molecular Mechanisms behind Obesity and Their Potential Exploitation in Current and Future Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8202 - 8202

Published: July 27, 2024

Obesity is a chronic disease caused primarily by the imbalance between amount of calories supplied to body and energy expenditure. Not only does it deteriorate quality life, but most importantly increases risk cardiovascular diseases development type 2 diabetes mellitus, leading reduced life expectancy. In this review, we would like present molecular pathomechanisms underlying obesity, which constitute target points for action anti-obesity medications. These include central nervous system, brain-gut-microbiome axis, gastrointestinal motility, A significant part article dedicated incretin-based drugs such as GLP-1 receptor agonists (e.g., liraglutide semaglutide), well brand new dual GIP agonist tirzepatide, all have become "block-buster" due their effectiveness in reducing weight beneficial effects on patient's metabolic profile. Finally, review highlights newly designed molecules with potential future obesity management that are subject ongoing clinical trials.

Language: Английский

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Gut Microbiota and DTI Microstructural Brain Alterations in Rodents Due to Morphine Self-Administration

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Abstract The opioid epidemic is an evolving health crisis in need of interventions that target all domains maladaptive changes due to chronic use and abuse. Opioids are known for their effects on the dopaminergic systems, addition neurocircuitry mediate behavior; however, new research lines looking at complementary brain gut. gut-brain axis (GBA) a bidirectional signaling process permits feedback between gut altered subjects with disorders. In this work, we determine longitudinal, non-invasive, in-vivo rodents trained self-administer morphine two weeks using MRI 16S rDNA analysis fecal matter. We assess occurring during both acute phase (early self-administration process, after days self-administration) (late self-administration), measurements benchmarked against baseline (naïve, non-drug state). Rats were surgically implanted intravenous jugular catheter morphine. allowed choose active lever, which delivers single infusion (0.4 mg/kg/infusion), or inactive had no consequence upon pressing. Animals scanned 7T scanner three times (baseline, acute, chronic), before scanning, matter was collected from each rat. After last scan session, subset animals euthanized, brains preserved immunohistochemistry analysis. found early microbiota diversity specific abundance as persisted into phase. MRI, identified alterations diffusivity indices within groups, showing main effect striatum, thalamus, somatosensory cortex. Finally, analyses revealed increased neuroinflammatory markers thalamus rats exposed Overall, demonstrate shapes microbiota. conclusion, precede anatomical observed features, neuroinflammation emerging crucial link mediating communication brain. This highlights potential addressing impacts use.

Language: Английский

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Is semaglutide a target therapy for acquired hypothalamic obesity?

Pituitary, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Language: Английский

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Brown Bears activates a Satiety Hormone Cholecystokinin (CCK) pathway in adipose tissue during hibernation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Abstract The brown bear ( Ursus arctos ) hibernates to survive cold winters without access food. It builds enormous subcutaneous fat stores during summer and relies on it for energy winter. Remarkably, the weight loss winter occurs muscle despite inactivity. Studying biology can therefore provide insights improving human health in obesity treatments. We here investigate adipose tissue biopsies obtained from free-living bears. During winter, a signature of genes involved food intake digestion is upregulated. Among these are several regulators satiety, substrate transport lipid metabolism. Interestingly, humans enriched distinct metabolic organs including, brain, intestine, stomach, liver even salivary glands. focused satiety brain/intestinal hormone cholecystokinin (CCK), which we demonstrate produced adipocytes, accompanied by an upregulation CCK receptor CCKBR. Importantly, was undetectable circulation presence sensory neurons suggest neuronal feedback mechanism within tissue. Using RNA sequencing, predict additionally 537 secreted proteins be seasonally regulated, 37 could confirmed with plasma proteomics. In conclusion, propose that bears have developed strategy healthy burning regulation through tissue-contained includes factors mediators safe turnover hibernation-dependent loss.

Language: Английский

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