Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice DOI Creative Commons
Ezgi Özcan,

Kristie B. Yu,

Lyna Dinh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

The gut microbiome is emerging as an important modulator of the anti-seizure effects classic ketogenic diet. However, many variations diet are used clinically to treat refractory epilepsy, and how different dietary formulations differentially modify in ways that impact seizure outcome poorly understood. We find prescribed infant formulas vary macronutrient ratio, fat source, fiber content also their ability promote resistance 6-Hz psychomotor seizures mice. By screening specific variables for on a model human microbial community, we observe fiber, rather than ratio or drives substantial metagenomic shifts. Addition fiber-deficient formula restores resistance, supplementing protective with excess further potentiates resistance. 13 sources types, identify distinct subsets responses community correspond increased In particular, supplementation seizure-protective fibers enriches representation genes related queuosine biosynthesis preQ

Language: Английский

Prebiotics as modulators of colonic calcium and magnesium uptake DOI Creative Commons
Friederike Stumpff, David Manneck

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)

Published: Jan. 13, 2025

Ca2+ and Mg2+ are essential nutrients, deficiency can cause serious health problems. Thus, lack of lead to osteoporosis, with incidence rising both in absolute age-specific terms, while is associated type II diabetes. Prevention via vitamin D or estrogen controversial, the bioavailability from supplements significantly lower than that milk products. Problems likely increase as populations age number people on vegan diets surges. Developing new therapeutic strategies requires a better understanding molecular mechanisms involved absorption by intestinal epithelia. The vitamin-D dependent, active pathway for uptake upper small intestine involving TRPV6 highly efficient but only accounts about 20% total uptake. Instead, most thought occur passive paracellular diffusion across ileum, although sufficiently high luminal concentrations difficult achieve.. Interestingly, colon caecum also have considerable capacity Mg2+, which unclear. Intriguingly, stimulating fermentation prebiotics enhances colonic absorption, rise ~10% ~30% total. Notably, releases protons, inhibits channels selective (TRPV6 TRPM6/TRPM7). Conversely, non-selective cation channel TRPV3 stimulated intracellular acidification numerous herbal compounds. Spicy, fiber-rich food, traditionally consumed many cultures, might enhance this pathway.

Language: Английский

Citations

1
Dietary fibers boost gut microbiota-produced B vitamin pool and alter host immune landscape DOI Creative Commons
Erica T. Grant, Amy Parrish, Marie Boudaud

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 23, 2024

Language: Английский

Citations

7
Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice DOI Creative Commons
Ezgi Özcan,

Kristie B. Yu,

Lyna Dinh

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 24, 2025

Abstract The gut microbiome modulates the anti-seizure effects of ketogenic diet, but how specific dietary formulations differentially modify in ways that impact seizure outcome is poorly understood. We find medical infant formulas vary macronutrient ratio, fat source, and fiber content promote resistance to 6-Hz seizures mice. Dietary fiber, rather than ratio or drives substantial metagenomic shifts a model human microbial community. Addition fiber-deficient formula restores resistance, supplementing protective with excess potentiates resistance. By screening 13 sources types, we identify responses community correspond increased Supplementing seizure-protective fibers enriches genes related queuosine biosynthesis preQ 0 decreases sucrose degradation TCA cycle, which are also seen seizure-protected mice fed fiber-containing formulas. This study reveals different diets, particular, mice, likely by modifying microbiome. Understanding interactions between microbiome, host susceptibility could inform novel microbiome-guided approaches treat refractory epilepsy.

Language: Английский

Citations

0
Research Progress on the Degradation of Human Milk Oligosaccharides (HMOs) by Bifidobacteria DOI Open Access

Ruitao Cai,

Jie Zhang, Yang Song

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 519 - 519

Published: Jan. 30, 2025

The purpose of this study was to investigate the degradation mechanism Bifidobacterium on breast milk oligosaccharides (HMOs) and its application in infant nutrition. composition characteristics HMOs were introduced, by described, including intracellular extracellular digestion species-specific differences. interaction between Bacteroides process degrading effect intestinal microecology analyzed. effects HMO formula powder microbiota infants discussed, simulating composition, regulating flora immune function, infection prevention, brain development. Finally, research results are summarized, future directions proposed provide for field

Language: Английский

Citations

0
Towards Improved Bioavailability of Cereal Inositol Phosphates, Myo-Inositol and Phenolic Acids DOI Creative Commons
Krzysztof Żyła, Aleksandra Duda‐Chodak

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 652 - 652

Published: Feb. 1, 2025

Cereals are among the foods rich in myo-inositol hexakisphosphate (phytic acid, IP6), lower phosphates (IPx), a wide range of phenolic compounds, as well vitamins, minerals, oligosaccharides, phytosterols and para-aminobenzoic attributed with multiple bioactivities, particularly associated prevention metabolic syndrome colon cancer. The bran fraction wheat, maize, brown rice other cereals contains high levels phytate, free total phenolics, endogenous enzymes such amylases, phytase, xylanase, β-glucanase feruloyl esterase, whose activities can be increased by germination. preliminary steps digestion begin oral cavity where substrates for action cereal salivary start to released from food matrix. IP6 phytate complexes arabinoxylans, starch protein bodies would eventually enhance absorption nutrients, including regulating tight junctions and, together ferulic acid (FA), maintain cell barrier integrity epithelial antibacterial immunity. In addition, both FA exert potent complementary antioxidant effects, while IPx generated through advanced hydrolysis microbial phytases may affect digestive enzyme activity incretin secretion, resulting modulated insulin glucagon release various diabetic complications. Contrary widespread negative attitudes towards this review, we present strategy selecting content, esterase endoxylanase activities, produce value-added health-promoting foods. compounds and/or generate substantial amounts “enzymatically inositol” (EGI), IP6, myo-inositol, that, FA, provide enhanced bioavailability nutrients synergistic effects not previously realised.

Language: Английский

Citations

0
(Poly)phenols as bioactive constituents linked to dietary fibre metabolic fate DOI
Jara Pérez‐Jiménez, Yolanda Sanz, Rosa M. Lamuela‐Raventós

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice DOI Creative Commons
Ezgi Özcan,

Kristie B. Yu,

Lyna Dinh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

The gut microbiome is emerging as an important modulator of the anti-seizure effects classic ketogenic diet. However, many variations diet are used clinically to treat refractory epilepsy, and how different dietary formulations differentially modify in ways that impact seizure outcome poorly understood. We find prescribed infant formulas vary macronutrient ratio, fat source, fiber content also their ability promote resistance 6-Hz psychomotor seizures mice. By screening specific variables for on a model human microbial community, we observe fiber, rather than ratio or drives substantial metagenomic shifts. Addition fiber-deficient formula restores resistance, supplementing protective with excess further potentiates resistance. 13 sources types, identify distinct subsets responses community correspond increased In particular, supplementation seizure-protective fibers enriches representation genes related queuosine biosynthesis preQ

Language: Английский

Citations

0