Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
BioFactors, Journal Year: 2025, Volume and Issue: 51(1)
Published: Jan. 1, 2025
Abstract Current lifestyles include calorie‐dense diets and late‐night food intake, which can lead to circadian misalignment. Our group recently demonstrated that sweet treats before bedtime alter the clock system in healthy rats, increasing metabolic risk factors. Therefore, we aimed assess impact of treat consumption time on rats fed a cafeteria diet (CAF). Moreover, since flavanols have beneficial effects disorders gene modulation, also investigated whether these phenolic compounds restore disruption caused by altered dietary patterns. For this, 64 Fisher were CAF for 9 weeks. In last 4 weeks, animals daily administered low dose sugar (160 mg/kg) as at 8 a.m. (ZT0) or p.m. (ZT12). Two other groups received 25 mg/kg grape seed addition treats. Finally, sacrificed different points (9 a.m., 3 p.m., a.m.). The results showed disturbances may be influenced administration, slightly reinforcing alterations diurnal rhythmicity serum biochemical parameters, hormones, hypothalamic genes with snacking. Flavanols improved health restored oscillation appetite‐signaling genes, showing greater ZT12. These highlight importance meal timing influencing physiological outcomes, even under diets. they suggest zeitgeber role flavanols, modulating contributing an profile feeding pattern conditions.
Language: Английский
Citations
0Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0Published: Jan. 1, 2024
Language: Английский
Citations
0