Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols

BioFactors, Journal Year: 2025, Volume and Issue: 51(1)

Published: Jan. 1, 2025

Abstract Current lifestyles include calorie‐dense diets and late‐night food intake, which can lead to circadian misalignment. Our group recently demonstrated that sweet treats before bedtime alter the clock system in healthy rats, increasing metabolic risk factors. Therefore, we aimed assess impact of treat consumption time on rats fed a cafeteria diet (CAF). Moreover, since flavanols have beneficial effects disorders gene modulation, also investigated whether these phenolic compounds restore disruption caused by altered dietary patterns. For this, 64 Fisher were CAF for 9 weeks. In last 4 weeks, animals daily administered low dose sugar (160 mg/kg) as at 8 a.m. (ZT0) or p.m. (ZT12). Two other groups received 25 mg/kg grape seed addition treats. Finally, sacrificed different points (9 a.m., 3 p.m., a.m.). The results showed disturbances may be influenced administration, slightly reinforcing alterations diurnal rhythmicity serum biochemical parameters, hormones, hypothalamic genes with snacking. Flavanols improved health restored oscillation appetite‐signaling genes, showing greater ZT12. These highlight importance meal timing influencing physiological outcomes, even under diets. they suggest zeitgeber role flavanols, modulating contributing an profile feeding pattern conditions.

Language: Английский

The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites

Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

The Impact of Circadian Rhythms and Obesity on Metabolic Dysfunction-Associated Steatotic Liver Disease: A Cross-Sectional Analysis of NHANES 2017-2020 Data

Published: Jan. 1, 2024

Language: Английский