Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension DOI Creative Commons
Meghamsh Kanuparthy,

Rishik Manthana,

Himanshu Kaushik

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 409 - 409

Published: Feb. 7, 2025

Cardioplegic arrest and cardiopulmonary bypass (CP/CPB) are known to engender microvascular dysfunction in patients undergoing cardiac surgery. These effects significantly varied by patient comorbidities including diabetes hypertension. Both hypertension associated with worse outcomes after surgery, partly related increased complications. In this review, we examine several key facets of CP/CPB: endothelial vasomotor dysfunction, altered gene protein expression, adherens junction programmed cell death as they relate This review examines both classical techniques, microvessel reactivity assays, modern multiomic approaches characterizing these changes.

Language: Английский

Impact of GLP‐1 Receptor Agonists on Alcohol‐Related Liver Disease Development and Progression in Alcohol Use Disorder DOI Open Access

Chia‐Chih Kuo,

Chun‐Hsien Li, Min‐Hsiang Chuang

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown promise in reducing alcohol consumption, but their impact on clinical outcomes patients with use disorder (AUD) remains unclear. We investigated the association between GLP-1RAs and development progression of alcohol-related liver disease (ArLD) AUD. Using TriNetX Research Network, we conducted two retrospective cohort studies comparing versus dipeptidyl peptidase-4 inhibitors (DPP-4is) type 2 diabetes. The first included AUD without ArLD (n = 7132 after propensity score matching), while second comprised established 1896 matching). Primary were incident hepatic decompensation cohort. In (median follow-up: 63.2 months), GLP-1RA users showed significantly lower risks developing compared to DPP-4i (incidence rate: 6.0 vs. 8.7 per 1000 person-years; HR: 0.62, 95% CI: 0.44-0.87, p 0.006). also associated reduced all-cause mortality (HR: 0.53, < 0.001). 28.2 demonstrated 39.5 51.4 0.66, 0.51-0.85, 0.001) users. progressing AUD, suggesting potential therapeutic benefits this population.

Language: Английский

Citations

1
Semaglutide and the risk of adverse liver outcomes in patients with nonalcoholic fatty liver disease and type 2 diabetes: a multi-institutional cohort study DOI

Chia-Chih Kuo,

Min‐Hsiang Chuang, Chun‐Hsien Li

et al.

Hepatology International, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

4
Do weight loss interventions challenge the obesity paradox in heart failure? DOI
Salva R. Yurista, Robert A. Eder, W. Scott Butsch

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advances in incretin therapies for targeting cardiovascular disease in diabetes DOI Creative Commons

Theresa L. Roberts,

Dana S. Hutchinson, Denise Wootten

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension DOI Creative Commons
Meghamsh Kanuparthy,

Rishik Manthana,

Himanshu Kaushik

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 409 - 409

Published: Feb. 7, 2025

Cardioplegic arrest and cardiopulmonary bypass (CP/CPB) are known to engender microvascular dysfunction in patients undergoing cardiac surgery. These effects significantly varied by patient comorbidities including diabetes hypertension. Both hypertension associated with worse outcomes after surgery, partly related increased complications. In this review, we examine several key facets of CP/CPB: endothelial vasomotor dysfunction, altered gene protein expression, adherens junction programmed cell death as they relate This review examines both classical techniques, microvessel reactivity assays, modern multiomic approaches characterizing these changes.

Language: Английский

Citations

0