Five-membered ring systems: with more than one N atom

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 255 - 304

Published: Jan. 1, 2023

Language: Английский

Efficient approach to 1,1′-bisindoles via copper(i)-catalyzed double domino reaction

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(39), P. 8003 - 8019

Published: Jan. 1, 2023

A highly efficient copper(I)-catalyzed approach for the synthesis of 1,1'-bisindoles that is based on formation four bonds in one step has been developed. The unprecedented three component reaction between molecule a 1,2-bis(2-bromoaryl)hydrazine and two molecules 1,3-diketone employing 10 mol% CuI as catalyst Cs2CO3 base DMSO at 100 °C 24 h delivers substituted with yields up to 92%. new method proceeds double domino condensation/Ullmann type C-C coupling. It allows an practical access from easily available starting materials.

Language: Английский

LiBF₄-Promoted Aromatic Fluorodetriazenation under Mild Conditions

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(17), P. 12826 - 12834

Published: Aug. 18, 2023

An efficient and mild fluorination method through LiBF4-promoted aromatic fluorodetriazenation of 3,3-dimethyl-1-aryltriazenes is developed. The reaction proceeds smoothly tends to complete within 2 h in the absence a protic acid or strong Lewis acid. This tolerates wide range functional groups affords aryl fluoride products moderate excellent yields.

Language: Английский