Solvent-free strategy for facile synthesis and cytotoxicity evaluation of benzimidazole derivatives

Tetrahedron, Journal Year: 2024, Volume and Issue: 156, P. 133940 - 133940

Published: March 11, 2024

Language: Английский

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t‐BuONa‐Mediated Redox Condensation between o‐Nitroanilines and Benzyl Alcohols towards 2‐Phenyl Benzimidazoles under Transition‐Metal‐Free Conditions

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(8)

Published: Feb. 21, 2023

Abstract A novel and environmentally benign method was developed for the direct synthesis of 2‐substituted benzimidazoles via a transition metal‐free redox tandem annulation benzyl alcohols ortho ‐nitroanilines in presence strong base, e.g. alkaline alkoxides or hydroxides. good tolerance functional groups observed, affording an array 2‐aryl benzimidazole derivatives high yields. Early mechanistic studies showed that sodium tert ‐butoxide could initiate hydrogen transfer from alcohol to nitro group ‐nitroaniline followed by imine condensation, cyclization, oxidation. This protocol features convenient tactic does not require any external oxidants solvents bioactive benzimidazole‐involving compounds.

Language: Английский

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Five-membered ring systems: with more than one N atom

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 281 - 332

Published: Jan. 1, 2023

Language: Английский

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