Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 28, 2024
This
study
investigates
the
repurposing
of
asphaltene,
a
petroleum
waste
product,
as
catalyst
for
organic
reactions.
Sulfonated
asphaltene
was
synthesized
and
evaluated
its
efficacy
in
catalyzing
Mannich
reaction,
displaying
notable
diastereoselectivity
operating
effectively
under
mild
conditions.
Characterization
catalyst's
chemical
composition,
structure,
thermal
stability
conducted
using
FT-IR,
TGA,
XRD,
CHN,
BET-BJH,
SEM,
EDS
analyses.
Employing
sulfonated
one-pot
multi-component
reaction
to
generate
β-amino
carbonyl
derivatives
ethanol
resulted
high
product
yields
after
4–7
h.
Notably,
exhibited
recyclability,
demonstrating
reusability
at
least
10
cycles.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(41)
Published: July 9, 2024
In
this
work,
we
describe
an
efficient
and
modular
method
for
enantiodivergent
accessing
P(V)-stereogenic
molecules
by
utilizing
the
catalytic
atroposelective
Catellani-type
C-H
arylation/desymmetric
intramolecular
N-arylation
cascade
reaction.
The
enantioselectivity
of
protocol
was
proved
to
be
tuned
polarity
solvent,
thus
providing
a
wide
range
both
chiral
enantiomers
in
moderate
good
yields
with
excellent
enantiomeric
excesses.
Noteworthy
is
that
strategy
developed
herein
represents
unprecedented
example
solvent-dictated
inversion
compounds.
European Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
Abstract
We
report
a
temperature‐dependent
regiodivergent
synthetic
strategy
for
the
construction
of
functionalized
maleimides
and
itaconimides
using
in‐situ
generated
pyridinium
ylides.
This
approach
enables
efficient
access
to
both
regioisomeric
products
under
mild
straightforward
reaction
conditions.
A
variety
salts
with
different
aromatic
alkyl
groups
were
successfully
used
N
‐aryl
‐alkyl
succinimides
demonstrating
broad
substrate
compatibility.
The
practicality
scalability
this
methodology
confirmed
through
scale‐up
experiments,
which
maintained
high
yields
reproducibility.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 22, 2025
The
use
of
organocatalysts
has
increased
significantly
in
recent
years
due
to
their
tremendous
applications
green
solvents.
Thus,
using
water
as
a
solvent
evolved
critical
factor.
Organocatalysts
are
efficient
and
sustainable
agents
for
promoting
chemical
reactions
water.
literature
been
extensively
reviewed,
the
various
three
fundamental
C–C
bond-forming
processes─the
Aldol,
Michael,
Mannich
aqueous
media─have
compiled
this
study.
can
overcome
limitations
conventional
organic
solvents
by
achieving
high
reaction
rates
regioselectivity
This
Review
highlights
advantages
media
these
key
reactions.
It
discusses
principles
behind
designing
effective
organocatalysts,
focusing
on
impact
selectivity,
sustainability,
efficiency.
study
also
summarizes
most
significant
advancements
over
past
decade.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Four-component
reactions
at
room
temperature
delivered
C–N
atropisomeric
peptide
analogues
possessing
both
central
and
axial
chirality
with
complete
diastereocontrol.
Reactions
elevated
selectively
afforded
the
other
diastereoisomer.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(41)
Published: July 9, 2024
Abstract
In
this
work,
we
describe
an
efficient
and
modular
method
for
enantiodivergent
accessing
P(V)‐stereogenic
molecules
by
utilizing
the
catalytic
atroposelective
Catellani‐type
C−H
arylation/desymmetric
intramolecular
N
‐arylation
cascade
reaction.
The
enantioselectivity
of
protocol
was
proved
to
be
tuned
polarity
solvent,
thus
providing
a
wide
range
both
chiral
enantiomers
in
moderate
good
yields
with
excellent
enantiomeric
excesses.
Noteworthy
is
that
strategy
developed
herein
represents
unprecedented
example
solvent‐dictated
inversion
compounds.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
A
Pd/C-catalyzed
dehydrogenative
[3
+
2]
cycloaddition
is
described
for
the
diastereoswitchable
synthesis
of
hexahydropyrrolo[2,1-a]isoquinolines
by
altering
solvents.
The
reaction
proceeds
through
a
sequential
formation
azomethine
ylides
from
tetrahydroisoquinoline
acetates
and
1,3-dipolar
with
2-nitroethenylbenzenes.
This
method
displayed
tunable
diastereoselectivity,
broad
substrate
scope
good
functional
group
compatibility.
Moreover,
gram-scale
selective
reductive
or
oxidative
transformations
product
further
demonstrate
utility
this
methodology.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(72), P. 9797 - 9800
Published: Jan. 1, 2024
The
synthesis
of
tetraarylmethanes
has
long
been
a
challenge
in
the
field
synthetic
chemistry.
In
this
study,
series
were
successfully
synthesized
through
formal
nucleophilic
substitution
reaction
indol-2-yl
diaryl
methanol
catalyzed
by
Brønsted
acid.
key
success
study
lies
suppressing
influence
water
molecules
forming
hydrogen
bonds
with
TFE
solvent.
This
process
leads
to
formation
active
2-indole
imine
methide
(2-IIM)
intermediates,
ensuring
successful
tetraarylmethanes.
Furthermore,
some
products
also
exhibited
potential
anticancer
activity.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
A
stereodivergent,
W-catalyzed
alkene
isomerization
is
reported,
leading
to
either
E
-
or
Z
-β,γ-unsaturated
carbonyl
compounds
based
on
the
ligand
environment
around
metal.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Catalytic
asymmetric
conjugate
additions
of
carbon
nucleophiles
have
emerged
as
a
potent
tool
for
constructing
multi-stereogenic
molecules
with
precise
stereochemical
control.
This
review
explores
the
concept
diastereodivergence
in
such
reactions,
focusing
on
strategies
to
achieve
selective
access
diverse
diastereomeric
products
upon
carbon-carbon
bond
formation.
Drawing
from
rich
array
examples,
we
delve
into
key
approaches
controlling
outcome
these
transformations,
including
alteration
alkene
geometry,
fine-tuning
reaction
parameters,
synergistic
catalysis,
and
isomerization
adducts.
Additionally,
highlight
iterative
additions,
showcasing
their
potential
diastereodivergent
synthesis
methyl-branched
stereocenters
1,3-relationships.
By
presenting
concentrated
overview
this
significant
topic,
aims
provide
valuable
insights
design
execution
stereodivergent
catalytic
offering
new
avenues
advancing
stereoselective
structural
diversity
organic
synthesis.
