Main Group Chemistry,
Journal Year:
2024,
Volume and Issue:
23(3), P. 299 - 327
Published: May 14, 2024
Nowadays,
the
dilemma
of
drug
resistance
to
antibacterial
strains
is
huge
concern.
Among
bacteria,
Escherchia
coli
(E.
coli)
major
pathogen,
which
found
in
human
and
other
animals.
It
responsible
for
variety
severe
diseases.
A
commonly
used
antibiotics
such
as
amoxicillin,
gentamycin,
etc
fluid
replacement
method
are
suggested
treatments
infections
caused
by
E.
coli.
In
a
study,
it
was
established
that
metal-based
heterocyclic
drugs
demonstrated
different
mode
action
compared
drugs.
Coumarin,
an
oxaheterocycle,
privileged
scaffold
medicinal
chemistry.
Metal
complexes
coumarin-derived
Schiff’s
bases
exhibit
broad
range
pharmacological
activities.
Therefore,
present
review
article,
we
have
focused
on
synthesis
metal
coumarin
derived
well
their
respective
base
ligands
activities
against
gram-negative
bacterium
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
7, P. 100469 - 100469
Published: Feb. 28, 2024
Functionalization
of
chitosan
as
salicylaldehyde
and
2-acetylphenol-based
thiosemicarbazone
involving
amino
group
at
C2
position
pyranose
ring
was
confirmed
by
comprehensive
characterization
spectroscopic
analytical
ways.
Both
the
low
molecular
weight
(Mw)
oligosaccharide
(CS)
(Mw
<
3000
Da,
degree
deacetylation
(DDA)
=
87%)
crab
shell
(CCS)
350
kDa,
DDA
67%)
functionalized
thiosemicarbazones
behaved
ONS
tridentate
ligand
to
form
square
planar
copper(II)
complexes
with
a
chloride
ion
an
additional
satisfy
co-ordination
sphere.
All
derivatives
were
found
thermally
stable
till
commencement
backbone
disruption
200°C.
The
MTT
assay
profiles
showed
conspicuous
enhancement
in
vitro
antitumorigenic
anticancer
activity
native
upon
its
functionalization
phenolic
carbaldehyde
thiosemicarbazones.
Further,
assays
more
often
revealed
further
lowering
cell
viability
comparison
high
derivatives,
lower
MCF-7
cancer
cells
than
tumorigenic
MDCK
cells.
Mw
DDA,
chitosan-functionalized
based
thiosemicarbazones,
their
have
minimal
toxicity
IC50
>600
μgmL−1
against
mouse
embryonic
normal
fibroblast
NIH3T3
These
results
indicatives
protonation
enhanced
preferential
cytotoxicity
biomaterials
negatively
charged
surfaces.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(5), P. 655 - 655
Published: May 17, 2024
In
this
innovative
research,
we
aim
to
reveal
pyrazole-based
Schiff
bases
as
new
multi-target
agents.
context,
re-synthesized
three
sets
of
bases,
5a–f,
6a–f,
and
7a–f,
evaluate
their
biological
applications.
The
data
from
in
vitro
assays
(including
antioxidant
scavenging
activities,
anti-diabetes,
anti-Alzheimer’s,
anti-inflammatory
properties)
the
7a–f
showed
that
six
5a,
5d,
5e,
5f,
7a,
7f
possess
highest
properties
among
compounds
evaluated.
cytotoxicity
against
lung
(A549)
colon
(Caco-2)
human
cancer
types,
well
normal
(WI-38)
cell
lines,
was
investigation
demonstrated
7a
are
active
cells,
while
two
5e
exhibited
towards
cells.
Additionally,
enzymatic
activities
caspase-3
Bcl-2
were
Furthermore,
assessed
silico
absorption,
distribution,
metabolism,
toxicity
(ADMT)
more
potent
bases.
After
modifying
structures
plan
further
extend
studies
future.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: June 26, 2024
Biginelli-type
heterocyclic
compounds
are
particularly
important
due
to
their
several
chemical
reactivities
and
various
range
of
pharmacological
activity.
Therefore
Biginelli
reaction
has
witnessed
modification
numerous
investigations
continuing
in
this
field
develop
more
effective
efficient
methodologies.
In
research,
Iron
(III)
schiff
base
immobilized
SBA-15
been
prepared
as
a
valuable,
efficient,
recoverable
catalyst
for
the
reaction.
The
morphology
was
identified
by
spectroscopic
characterization
techniques
structural
microscopic
analysis
including
Fourier
transform
infrared
(FT-IR)
patterns,
X-ray
diffraction
(XRD)
powder
crystal
method,
Energy-dispersive
spectroscopy
(EDS)
study,
Thermogravimetric-Differential
thermal
(TGA-DTA),
Transmission
electron
microscopy
(TEM)
Field
emission
scanning
(FE-SEM)
images.
containing
3,4-dihydropyrimidines
octahydroquinazolinones
were
conveniently
synthesized
catalyzed
protocol
from
cycloaddition
aromatic
aldehydes
with
1,3-dicarbonyl
substrates
urea
via
ultrasonic
waves.
advantages
presented
approach
high
yields
easy
isolation
products,
shorter
times,
milder
conditions,
stability
reusable
catalyst.
combination
heterogeneous
radiation
can
make
catalytic
reactions
than
traditional
ways
attractive
academic
researchers
application
scholars
industry.
Polish Journal of Chemical Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
Abstract
The
chemical
industry
is
one
of
the
key
elements
in
improving
quality
human
life.
At
same
time,
it
generates
pollution
influencing
ecosystem
and
our
health.
To
limit
or
remove
some
reasons
for
two
decades
less
harmful
approaches
to
synthesis
various
organic
compounds
were
developed.
Among
compounds,
azomethines,
also
known
as
Schiff
bases,
are
particular
interest
biochemistry,
medicine,
pharmacy.
For
over
twenty
years
many
novel
these
have
been
investigated.
Toxic
solvents
(benzene,
toluene)
replaced
with
water,
fruit
juice,
white
egg,
cases,
temperature
time
process
significantly
reduced.
In
review,
conventional
green
bases
presented
a
focus
on
effectiveness
methods,
including
advantages
disadvantages.
