Marine Cyanobacteria: A Rich Source of Structurally Unique Anti-Infectives for Drug Development DOI Creative Commons
Lik Tong Tan, Nurul Farhana Salleh

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5307 - 5307

Published: Nov. 10, 2024

Marine cyanobacteria represent a promising yet underexplored source of novel natural products with potent biological activities. Historically, the focus has been on isolating cytotoxic compounds from marine cyanobacteria, but substantial number these photosynthetic microorganisms also produce diverse specialized molecules significant anti-infective properties. Given global pressing need for new lead compounds, this review provides concise comprehensive overview current knowledge secondary metabolites derived cyanobacteria. A majority were isolated free-living filamentous while several examples cyanobacterial symbionts. In addition, SAR studies and synthetic analogs based selected will be featured. With more than 200 molecules, presents their antibacterial, antifungal, antiviral, antiprotozoal, molluscicidal activities, chemical information covered in literature up to September 2024.

Language: Английский

Progress in the discovery and development of anticancer agents from marine cyanobacteria DOI Creative Commons
Hendrik Luesch,

Emma K. Ellis,

Qi-Yin Chen

et al.

Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

We describe the pipeline of anticancer agents from marine cyanobacteria, highlighting critical steps discovery towards development, including identification molecular target and mechanism action, solving supply problem.

Language: Английский

Citations

6
Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D DOI Creative Commons

Huiru Nan,

Xiong-En Long,

Jianfei He

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(3), P. 99 - 99

Published: Feb. 24, 2025

Lagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and HCT116 colon cancer cells. A significant challenge associated with lagunamide its propensity for intramolecular acyl migration, which leads to formation of contracted 24-membered analog, D′. This structural rearrangement complicates isolation, characterization, synthesis. In this study, total synthesis was achieved 14-step longest linear sequence, starting known intermediate 17, an overall yield 4.6%. The synthetic strategy involved several key transformations, including Ghosh’s TiCl4-promoted anti-aldol reaction, Corey–Bakshi–Shibata reduction (CBS reduction), cross-metathesis, Pinnick oxidation, Yamaguchi esterification. Furthermore, effort unambiguously confirmed stereochemistry natural product.

Language: Английский

Citations

0
Marine Cyanobacteria: A Rich Source of Structurally Unique Anti-Infectives for Drug Development DOI Creative Commons
Lik Tong Tan, Nurul Farhana Salleh

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5307 - 5307

Published: Nov. 10, 2024

Marine cyanobacteria represent a promising yet underexplored source of novel natural products with potent biological activities. Historically, the focus has been on isolating cytotoxic compounds from marine cyanobacteria, but substantial number these photosynthetic microorganisms also produce diverse specialized molecules significant anti-infective properties. Given global pressing need for new lead compounds, this review provides concise comprehensive overview current knowledge secondary metabolites derived cyanobacteria. A majority were isolated free-living filamentous while several examples cyanobacterial symbionts. In addition, SAR studies and synthetic analogs based selected will be featured. With more than 200 molecules, presents their antibacterial, antifungal, antiviral, antiprotozoal, molluscicidal activities, chemical information covered in literature up to September 2024.

Language: Английский

Citations

1