Beyond Traditional Synthesis: Electrochemical Approaches to Amine Oxidation for Nitriles and Imines

ACS Organic & Inorganic Au, Journal Year: 2024, Volume and Issue: 4(5), P. 471 - 484

Published: June 21, 2024

The electrochemical oxidation of amines to nitriles and imines represents a critical frontier in organic electrochemistry, offering sustainable pathway these valuable compounds. Nitriles are pivotal various industrial applications, including pharmaceuticals, agrochemicals, materials science. This review encapsulates the recent advancements electrooxidation process, emphasizing mechanistic understanding, electrode material innovations, optimization reaction conditions, exploration solvent electrolyte systems. Additionally, addresses operational parameters that significantly affect such as current density, temperature, surface, insights into their for enhanced performance. By providing comprehensive view state prospects amine imines, this aims inspire further development, innovation, research promising area green chemistry.

Language: Английский

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Electrosynthesis of amide: A green pathway for future pharmaceuticals

IOP Conference Series Earth and Environmental Science, Journal Year: 2024, Volume and Issue: 1419(1), P. 012021 - 012021

Published: Dec. 1, 2024

Abstract Amide bonds are prevalent in peptides, synthetic polymers, insecticides, and pharmaceuticals. These play a critical role medicinal chemistry due to their stability, ability interact with biological targets, flexibility designing bioactive compounds. Many methods have been devised date for the synthesis of amides, however majority them rely on coupling agents an excess bases neutralize acid produced during reaction. techniques low atom economy generate lot waste, making unfriendly environment. Greener chemical developed as result growing worldwide awareness environmental issues drive towards sustainability. In this context, new approaches being based concepts green sustainable chemistry, particularly through emerging research utilizing organic electrosynthesis. This review aims demonstrate application amide electrosynthesis pathway development future

Language: Английский

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Amide Synthesis from DDQ-Mediated Electrochemical Beckmann Rearrangement

Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134324 - 134324

Published: Oct. 1, 2024

Language: Английский

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N-Acylation Reactions of Amines

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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