Synthetic Methodology, SAR and Pharmacology of Commercialized Preparations Employing 1, 2, 4‐Triazole Analogues DOI
Sucheta Singh,

Meenakshi Kaira,

Hrithik Dey

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract The domain of medicinal chemistry has witnessed a notable surge interest in triazoles owing to their unique structural characteristics and wide range applications. versatility synthesis methods facilitated the creation compound libraries with remarkable pharmacological activities, including antiviral, antiepileptic, anxiolytic, hypnotic/sedatives anticancer, antifungal, antidepressant activities. Several techniques have been documented literature for generating 1,2,4‐triazole derivatives. mechanisms governing effects formulations containing 1,2,4‐triazoles were elucidated made clear. In addition reviewing existing marketed formulations, this review explores emerging trends innovations field. This offers comprehensive perspective on importance influencing contemporary research, fostering innovation, driving technological progress.

Language: Английский

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies DOI Creative Commons

Cengiz Zobi,

Öztekin Algül

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(1)

Published: Jan. 1, 2025

ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates. The rising incidence of these infections, coupled with increasing antifungal resistance, underscores the urgent need for novel therapeutic strategies. Current drugs target cell membrane, wall, or intracellular components, but resistance mechanisms such as altered drug‐target interactions, enhanced efflux, adaptive cellular responses have diminished efficacy. Recent research has highlighted potential dual inhibitors that simultaneously multiple pathways enzymes involved growth survival. Combining pharmacophores, lanosterol 14α‐demethylase (CYP51), heat shock protein 90 (HSP90), histone deacetylase (HDAC), squalene epoxidase (SE) inhibitors, led development compounds activity reduced resistance. This dual‐target approach, along chemical scaffolds, not only represents a promising strategy combating is also being utilized anticancer agents. review explores new agents employ mono‐, dual‐, multi‐target strategies combat IFIs. We discuss emerging targets, mechanisms, innovative approaches offer hope managing challenging infections.

Language: Английский

Citations

2
Functionalized Triazoles: Design, Synthesis and Chemical Characterization of 1,2,3-triazolylmethylthio-1,3,4-oxadiazole derivatives as Insecticidal and Antibacterial Agents DOI
Hany M. Abd El‐Lateef, Mai M. Khalaf, Mohamed Gouda

et al.

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: 102(2), P. 101578 - 101578

Published: Jan. 11, 2025

Language: Английский

Citations

1
Therapeutic potential of chalcone-1,2,3-triazole hybrids as anti-tumour agents: a systematic review and SAR studies DOI
Sakshi Priya, Md. Shafiqul Islam,

Shivani Kasana

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 17(4), P. 449 - 465

Published: Jan. 31, 2025

The study of chalcone-1,2,3-triazole hybrids for anticancer activity is quite a recent area focus, primarily because the increasing demand developing new drugs to treat cancer. chalcones and 1,2,3-triazole rings in hybrid compounds has recently emerged as promising strategy novel agents. ring, known its stability hydrogen bonding capabilities, enhances target binding affinity these hybrids. Chalcones possess an α,β-unsaturated carbonyl system crucial their synergistic effect two moieties results with potent properties. This review explores structure-activity relationship studies which revealed that electronic lipophilic properties substituents on phenyl significantly influence activity. Electron-donating electron-withdrawing groups can affect cellular uptake engagement. Incorporating various into ring improve selectivity potency against specific cancer cell lines. These often exert effects through apoptosis cycle disruption. Recent research indicates chalcone hold therapeutic promise Further optimization SAR in-depth mechanistic investigations could lead development highly selective agents minimal toxicity.

Language: Английский

Citations

1
The current landscape of 1,2,3‐triazole hybrids with anticancer therapeutic potential: Part I DOI
Shanshan Huang,

Zhi Xu,

Yafei Zhuang

et al.

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Cancer, with its steadily increasing morbidity and mortality, will continue to pose a threat humanity over an extended period. Chemotherapeutics play indispensable role in cancer treatment, hundreds of drugs have been approved for this purpose. Nevertheless, the fight against remains formidable challenge. This is mainly due emergence multidrug resistance severe side effects associated currently available anticancer drugs. Consequently, there urgent imperative explore novel chemotherapeutic agents. 1,2,3‐Triazoles belong one most privileged classes nitrogen‐containing five‐membered heterocycles are regarded as prominent sources development innovative chemotherapeutics. 1,2,3‐Triazole hybrids, which possess multitargeted mechanisms action within progression pathway, hold potential overcome mitigate effects. Furthermore, several 1,2,3‐triazole hybrids already therapy or under clinical evaluation. clearly demonstrates that valuable scaffolds treatment eradication cancer. review aims provide insights into therapeutic along their action, crucial aspects design, structure–activity relationships (SARs). It encompasses articles published from 2021 onward.

Language: Английский

Citations

1
The Current Landscape of 1,2,3‐triazole Hybrids With Anticancer Therapeutic Potential: Part II DOI

Zhi Xu,

Junna Liu

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(4)

Published: April 1, 2025

Chemotherapy has been identified as a validated and critically important strategy for the treatment of cancer, but multidrug resistance serious side effects remain grand challenges effective cancer therapy. This highlights urgent need development alternative chemical entities that can modulate more than one biological target with high specificity multitargeted mechanism action in disease progression pathway. 1,2,3-Triazole hybrids have potential to act on dual/multiple targets cells simultaneously possess potent broad-spectrum activity against various cancers, including drug-resistant forms. Thus, 1,2,3-triazole are valuable scaffolds eradication cancer. review provides comprehensive overview evolving landscape their vitro vivo anticancer potential, structure-activity relationships well mechanisms also discussed, covering articles published from 2021 onward.

Language: Английский

Citations

1
Unraveling the Therapeutic Potential of Alzheimer’s Drugs: A Comprehensive Review DOI
Anjali Rani,

Javed Khan,

Lakshika Choudhary

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134517 - 134517

Published: Feb. 1, 2025

Language: Английский

Citations

0
Regioselective Synthesis of 5‐(1,2,3‐Triazol‐1‐yl)isoxazoles by Cyclization of 5‐Azidoisoxazoles with Active Methylene Compounds DOI

Sevastian E. Dronov,

Dmitry A. Vasilenko,

Yuri K. Grishin

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract A facile metal‐free approach to 5‐(1,2,3‐triazol‐1‐yl)isoxazoles bearing a variety of functional groups in both heterocyles has been developed. cyclization 3‐EWG‐5‐azidoisoxazoles with compounds possessing active methylene group proceeds smoothly under mild conditions the presence triethylamine or Cs 2 CO 3 alcohols DMF affording fused hybrid triazole‐isoxazole high yields up 98%. Some mechanistic aspects reaction are discussed.

Language: Английский

Citations

0
Recent Developments Towards the Synthesis of Triazole Derivatives: A Review DOI Creative Commons
Issam Ameziane El Hassani,

Khouloud Rouzi,

Anouar Ameziane El Hassani

et al.

Organics, Journal Year: 2024, Volume and Issue: 5(4), P. 450 - 471

Published: Oct. 24, 2024

The triazole scaffold is a crucial component of heterocyclic chemistry, serving as basic building block in organic synthesis, materials science, and medicinal chemistry. Triazole five-membered ring composed three nitrogen atoms two carbon atoms, it exists isomeric forms: 1,2,3-triazole 1,2,4-triazole. Compounds featuring the are important heterocycles known for their diverse biological activities, including antimicrobial, antiproliferative, antimalarial, anticonvulsant, anti-inflammatory, antineoplastic, antiviral, analgesic, anticancer properties. As result, derivatives have attracted significant attention from researchers. This review aims to provide thorough overview published studies on synthesis derivatives, highlighting various methods obtaining moiety. These include classical approaches well microwave ultrasound-assisted techniques.

Language: Английский

Citations

3
Synthetic Methodology, SAR and Pharmacology of Commercialized Preparations Employing 1, 2, 4‐Triazole Analogues DOI
Sucheta Singh,

Meenakshi Kaira,

Hrithik Dey

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract The domain of medicinal chemistry has witnessed a notable surge interest in triazoles owing to their unique structural characteristics and wide range applications. versatility synthesis methods facilitated the creation compound libraries with remarkable pharmacological activities, including antiviral, antiepileptic, anxiolytic, hypnotic/sedatives anticancer, antifungal, antidepressant activities. Several techniques have been documented literature for generating 1,2,4‐triazole derivatives. mechanisms governing effects formulations containing 1,2,4‐triazoles were elucidated made clear. In addition reviewing existing marketed formulations, this review explores emerging trends innovations field. This offers comprehensive perspective on importance influencing contemporary research, fostering innovation, driving technological progress.

Language: Английский

Citations

0