Recent advances in the synthesis of N-heterocycles from α-amino acids mediated by iodine DOI
Dongsheng Yang, Jia‐Chen Xiang, An‐Xin Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The synthesis of N-heterocycles has received extensive attention from scientists considering their important role in organic synthesis, pharmaceuticals, and materials chemistry. α-Amino acids (α-AAs), both natural non-natural, are structurally diverse, containing basic amino groups, acidic carboxyl various side-chain R groups a single molecule. Given structural properties wide range sources, they have undoubtedly become suitable synthetic building blocks for synthesis. However, conventional transformations (AAs) focus on the independently. Conversions these two prominent functional generally do not affect alpha positions branched chains. Over past decade, with application iodine (I

Language: Английский

Palladium-Catalyzed Cascade Reactions for Synthesis of Heterocycles Initiated by C(sp3)–H Functionalization DOI Open Access
Dan Yuan, Ziting Xu,

Yang Zhou

et al.

Catalysts, Journal Year: 2025, Volume and Issue: 15(1), P. 72 - 72

Published: Jan. 14, 2025

Heterocycles are widely present in natural products, pharmaceuticals, and organic functional materials. In heterocycle synthesis, Pd-catalyzed cascade C–H functionalization has been regarded as one of the most powerful approaches due to its advantages terms high atom efficiency readily available starting this review, we will briefly introduce major advances palladium-catalyzed C(sp3)–H activation annulation for constructing different types heterocycles through inter- intramolecular pathways from 2010 2023.

Language: Английский

Citations

0
Iodine-Catalyzed Room-Temperature Aerobic Oxidation of C(sp3)–H Bonds and Its Application in the Synthesis of Quinoxaline Derivatives DOI

Hanyu Xiong,

Longxing Wang,

Yuanyang Mu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

An iodine-catalyzed aerobic oxidation reaction of C(sp3)-H bonds was established at room temperature. In this transformation, iodine acts as a Lewis acid catalyst, and the pyridine moiety in substrate plays crucial role. Under optimum conditions, picolyl ketone substrates were smoothly transformed into corresponding 1,2-dicarbonyl compounds, subsequent introduction 1,2-diaminobenzenes mixture led to formation various quinoxaline derivatives. This synthetic process does not use transition metals also features mild operational simplicity, gram-scale synthesis.

Language: Английский

Citations

0
Synthesis of 6-oxa-Spiro[4.5]decane Derivatives by Merging Ring-Opening of Benzo[c]oxepines and Formal 1,2-Oxygen Migration DOI

Yong-Dong Du,

Linlin Ma, Chun‐Yan Wu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 15953 - 15963

Published: Oct. 16, 2024

A facile one-pot synthetic method has been developed for constructing 6-

Language: Английский

Citations

2
Recent advances in the synthesis of N-heterocycles from α-amino acids mediated by iodine DOI
Dongsheng Yang, Jia‐Chen Xiang, An‐Xin Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The synthesis of N-heterocycles has received extensive attention from scientists considering their important role in organic synthesis, pharmaceuticals, and materials chemistry. α-Amino acids (α-AAs), both natural non-natural, are structurally diverse, containing basic amino groups, acidic carboxyl various side-chain R groups a single molecule. Given structural properties wide range sources, they have undoubtedly become suitable synthetic building blocks for synthesis. However, conventional transformations (AAs) focus on the independently. Conversions these two prominent functional generally do not affect alpha positions branched chains. Over past decade, with application iodine (I

Language: Английский

Citations

0