Solvent-Controlled and Highly Chemoselective Reduction of α,β-Unsaturated Ketones and Aldehydes DOI
Yukun Zhang, Eman Fayad, Hanadi A. Katouah

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Herein, we establish two highly efficient reductions of α,β-unsaturated ketones and aldehydes via Raney nickel-catalyzed hydrogenation with distinct chemoselectivity, which is controlled by the solvent. This methodology demonstrates a brilliant result when reducing to or alcohols. High isolated yields were obtained for series benzalacetone- cinnamaldehyde-derived substrates without additional column chromatographic purification. The practicability was demonstrated natural products synthesizing approved drug.

Language: Английский

Recent advance in metal-organic frameworks based catalysts for production of fine chemicals via thermal catalysis DOI
Rui Fu, Weizuo Li, Guangyu He

et al.

Molecular Catalysis, Journal Year: 2025, Volume and Issue: 573, P. 114811 - 114811

Published: Jan. 7, 2025

Language: Английский

Citations

0
Green procedures for synthesizing potential hNMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a superparamagnetic Fe3O4@APTMS@Cp2ZrClx (x = 0, 1, 2) nanocatalyst DOI Creative Commons
Hossein Mousavi, Behzad Zeynizadeh,

Farhad Sepehraddin

et al.

Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this research, we have developed diverse strategies for synthesizing potential h NMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a mesoporous zirconocene-containing nanocatalyst.

Language: Английский

Citations

0
Solvent-Controlled and Highly Chemoselective Reduction of α,β-Unsaturated Ketones and Aldehydes DOI
Yukun Zhang, Eman Fayad, Hanadi A. Katouah

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Herein, we establish two highly efficient reductions of α,β-unsaturated ketones and aldehydes via Raney nickel-catalyzed hydrogenation with distinct chemoselectivity, which is controlled by the solvent. This methodology demonstrates a brilliant result when reducing to or alcohols. High isolated yields were obtained for series benzalacetone- cinnamaldehyde-derived substrates without additional column chromatographic purification. The practicability was demonstrated natural products synthesizing approved drug.

Language: Английский

Citations

0