A Comprehensive Review of One‐Pot Multicomponent Strategies for Oxazole Synthesis DOI
S. Lokesh Kumar, C.J. Binish

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(19)

Published: May 1, 2025

Abstract Oxazole derivatives represent a crucial class of heterocycles with broad applications spanning medicinal chemistry, materials science, and organic synthesis. Their structural versatility biological significance have fueled ongoing efforts to develop efficient sustainable synthetic methodologies. However, despite their importance, the literature on multicomponent synthesis oxazoles remains relatively sparse, necessitating comprehensive review. This review examines diverse, approaches, encompassing three‐ four‐component reactions. The highlights versatility, efficiency, adaptability these methods, underscoring evolution oxazole focus functional group diversity, environmental considerations, scalability. Covering developments from 1990 early 2025, this provides critical overview progress challenges in synthesis, aiming support future drug development advanced materials.

Language: Английский

The Liebeskind–Srogl Cross-Coupling Reaction Towards the Synthesis of Biologically Active Compounds DOI

Jan Chasák,

Ignacy Janicki, Lucie Brulíková

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117526 - 117526

Published: March 1, 2025

Language: Английский

Citations

0

A Comprehensive Review of One‐Pot Multicomponent Strategies for Oxazole Synthesis DOI
S. Lokesh Kumar, C.J. Binish

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(19)

Published: May 1, 2025

Abstract Oxazole derivatives represent a crucial class of heterocycles with broad applications spanning medicinal chemistry, materials science, and organic synthesis. Their structural versatility biological significance have fueled ongoing efforts to develop efficient sustainable synthetic methodologies. However, despite their importance, the literature on multicomponent synthesis oxazoles remains relatively sparse, necessitating comprehensive review. This review examines diverse, approaches, encompassing three‐ four‐component reactions. The highlights versatility, efficiency, adaptability these methods, underscoring evolution oxazole focus functional group diversity, environmental considerations, scalability. Covering developments from 1990 early 2025, this provides critical overview progress challenges in synthesis, aiming support future drug development advanced materials.

Language: Английский

Citations

0