The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

We herein report a dual visible-light photoredox- and copper-catalyzed Z-selective allyl trifluoromethylation reaction of allylamine by using trifluoromethylpyridinium salt (TFSP) as the trifluoromethyl radical precursor. Various thermodynamically disfavorable trifluoromethylated cis-enamides were accessible with moderate to good isolated yields. Cuprous oxide or copper nanoclusters crucial co-catalyst for this transformation.

Language: Английский