Al-Qadisiyah Journal Of Pure Science,
Journal Year:
2021,
Volume and Issue:
26(4), P. 364 - 379
Published: Aug. 15, 2021
This
research.
Included
the
preparation.
and
characterization
some
novel.
Six
seven
membered
Heterocyclic.
Compounds
(
oxazepine
,
thiazine
quinazoline
)
The
first
step
in
clode
react
2-amino-6-
methoxybenzothiazole
with
4-
amino
acetophenone
to
get
Schiff
base
derivative
(1).
second
(1)
4
-hydroxy
schiff
(2)
last
involve
Phthalic
Maleic
Succinic)
anhydride
.get
derivatives
(3,4and
5)
also
with(2-amino
benzoic
acid)
(2-mercaptobenzoic
acid
(6)and
(7)
respectively
.the
physical;
properties
of
prepared;
These
Compounds.
Were
Identification
(FT-IR)
,(1H-NMR)
(13C-NMR)
by
spectroscopy
thene
study
their
biological
effect
on
two
types
bacteria
Staphylococcus
aureuses
(Gram
positive)
Escherichia
coli
Negative)
The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(4), P. 2366 - 2371
Published: Jan. 24, 2019
This
paper
reports
the
tandem
reaction
strategy
of
Passerini/Staudinger/aza-Wittig
based
on
in
situ
capture
isocyanides.
According
to
this
strategy,
isocyanides
are
synthesized
and
immediately
work
as
substrate
for
Passerini
postmodification
one
pot.
In
addition,
two
types
new
compounds,
5-oxo-3,5-dihydrobenzo[e][1,4]oxazepines
6-oxo-5,6-dihydro-2H-1,4-oxazines,
were
using
that
includes
five-step
transformations
New Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
45(36), P. 16389 - 16425
Published: Jan. 1, 2021
Molecular
iodine
contributes
significantly
to
organic
transformations
in
synthetic
chemistry.
It
works
effectively
due
its
mild
Lewis
acidic
character,
ability
as
an
oxidizing
agent,
good
moisture
stability,
and
easy
availability.
A
simple
methodology
for
the
synthesis
of
bicyclic
6,7-dihydrofuro[3,4-
c
]pyridines
is
reported.
The
skeletal
diversity
synthesized
heterobicyclic
frame
may
present
new
nitrogen-
and
oxygen-based
hybrid
systems
medicinal
chemistry.
Organic Letters,
Journal Year:
2019,
Volume and Issue:
21(14), P. 5457 - 5461
Published: July 8, 2019
An
effective
base-controlled
divergent
annulation
reaction
of
2-bromophenylacetonitriles
and
ynones
has
been
developed.
Various
functionalized
5-cyanobenzoxepines
benzofuro[2,3-b]pyridines
were
obtained
with
a
broad
substrate
scope
high
regioselectivity
in
moderate
to
excellent
yield.
Of
importance,
an
unexpected
O-rearrangement
access
was
observed
using
1,8-diazabicyclo[5.4.0]undec-7-ene
(DBU)
as
the
base,
possible
mechanism
supported
by
18O-labeled
experiments.
In
addition,
gram-scale
synthesis
further
transformation
product
studied.
The Journal of Organic Chemistry,
Journal Year:
2018,
Volume and Issue:
83(15), P. 8376 - 8389
Published: June 24, 2018
An
efficient,
general,
and
unprecedented
methodology
for
the
synthesis
of
2-methylene-2,3-dihydro-1,4-thiazepines
from
N-propargylic
β-enaminones
is
described.
Initially,
were
thionated
with
Lawesson's
reagent
in
good
to
high
yields,
then
resulting
β-enaminothiones
subjected
electrophilic
cyclization.
When
treated
zinc
chloride
refluxing
chloroform,
underwent
cyclization
yield
yields.
A
general
trend
was
observed
all
β-enaminothiones,
proceeded
efficiency
large
functional
group
tolerance.
This
process
also
applicable
internal
alkyne-tethered
β-enaminothiones.
operationally
simple
facile
method
may
represent
a
very
rapid
entry
library
functionalized
1,4-thiazepines
area
pharmaceuticals.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(9), P. 6289 - 6304
Published: April 19, 2021
A
one-pot
two-step
protocol
for
the
synthesis
of
2-acetyl-1H-pyrroles
from
N-propargylic
β-enaminones
was
described.
When
treated
with
zinc
chloride
in
refluxing
chloroform,
produced
situ
2-methylene-2,3-dihydro-1,4-oxazepines,
which,
upon
further
methanol
chloride,
afforded
2-acetyl-1H-pyrroles.
The
process
found
to
be
general
a
wide
variety
and
yielded
diverse
range
good
high
yields
large
substrate
scope
functional
group
tolerance.
This
operationally
easy
method
may
provide
rapid
access
functionalized
pharmacological
interest.
The Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
85(7), P. 4937 - 4950
Published: March 10, 2020
A
facile
and
efficient
method
for
the
synthesis
of
3-[(4-nitrophenyl)thio]-substituted
4-methylene-1-pyrrolines
is
described.
When
treated
with
4-nitrobenzenesulfenyl
chloride
in
refluxing
acetonitrile,
N-propargylic
β-enaminones
produced
α-sulfenylated
β-enaminones,
which,
presence
sodium
hydride
or
cesium
carbonate,
underwent
nucleophilic
cyclization
to
afford
4-methylene-3-[(4-nitrophenyl)thio]-1-pyrrolines
good
high
yields.
It
was
shown
first
time
that
on
β-enaminone
systems,
α-sulfenylation
dominates
over
formation
thiirenium
ion.
This
one-pot
two-step
process
found
be
general
a
variety
demonstrated
tolerance
diversity
aromatic
heteroaromatic
groups
electron-withdrawing
electron-donating
substituents.
also
applicable
internal
alkyne-tethered
β-enaminones.
The
enrichment
1-pyrroline
core
an
aryl
sulfide
moiety
might
exhibit
potential
molecules
pharmacological
interest.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 16, 2024
In
this
paper,
we
describe
an
efficient
InCl3-catalyzed
two-component
reaction
of
1-(2-aminophenyl)pyrroles/indoles
and
2-propargyloxybenzaldehydes
for
the
direct
synthesis
12bH-benzo[6,7]1,4-oxazepino[4,5-a]pyrrolo/indolo[2,1-c]quinoxalines.
This
high
atom-
step-economical
one-pot
process
generates
three
new
C/N–C
bonds
in
a
single
synthetic
operation,
resulting
formation
six-
seven-membered
heterocyclic
rings.
The
easy
availability
starting
materials,
use
relatively
inexpensive
indium
catalyst,
good
substrate
scope
are
salient
features
strategy.
proposed
mechanistic
pathway
involves
imine
formation,
two
consecutive
cyclizations
via
electrophilic
aromatic
substitution
nucleophilic
addition
reactions,
H
shift
step.
