Synthesis And Characterization ( Oxazepine , Thiazine and Quinazoline ) Derivatives And Study The Biological Activity As Antibacterial DOI Creative Commons

Adel Kareem Jasim,

Shaimaa Adnan

Al-Qadisiyah Journal Of Pure Science, Journal Year: 2021, Volume and Issue: 26(4), P. 364 - 379

Published: Aug. 15, 2021

This research. Included the preparation. and characterization some novel. Six seven membered Heterocyclic. Compounds ( oxazepine , thiazine quinazoline ) The first step in clode react 2-amino-6- methoxybenzothiazole with 4- amino acetophenone to get Schiff base derivative (1). second (1) 4 -hydroxy schiff (2) last involve Phthalic Maleic Succinic) anhydride .get derivatives (3,4and 5) also with(2-amino benzoic acid) (2-mercaptobenzoic acid (6)and (7) respectively .the physical; properties of prepared; These Compounds. Were Identification (FT-IR) ,(1H-NMR) (13C-NMR) by spectroscopy thene study their biological effect on two types bacteria Staphylococcus aureuses (Gram positive) Escherichia coli Negative)

Language: Английский

Synthesis of 1,3-Benzoxazepine-1,5-diones containing Oxadiazole unit with Assessment of their verves Athwart Bacteria DOI
Zeid Hassan Abood,

Husham Attallah Suhail,

Zahraa Kadum Chafcheer

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2021, Volume and Issue: unknown, P. 1837 - 1841

Published: April 29, 2021

Treatment of 4-aminobenzoyl hydrazide (1) with (CS2) and potassium hydroxide in absolute (EtOH) resulted formation 5-(4-aminophenyl)-2-thiol-1,3,4-oxadiazole (2). Compound (2) has been converted to the diazonium salt which reacted 2-hydroxybenzaldehyde for producing aldehyde derivative (3). Reaction compound (3) (4-nitroaniline, 3-nitroaniline, 2-nitroaniline, 4-chloroaniline, 2-chloroaniline, 2,4-dichloroaniline 4-bromoaniline) by (MW) method afforded seven Schiff bases (4a–g). Cycloaddition imines (4a–g) phthalic anhydride microwave oven gave 1,3-benzoxazepine-1,5-diones (5a–g) bearing oxadiazole moiety. Screening verves final benzoxazepines was done on Staphylococcus aurous Escherichia coli. The implications explained that compounds (5b, 5c, 5d, 5e, 5f 5g) possess higher effect than gentamycin against aurous. Moreover, 1,3-oxazepine-1,5-diones (compounds 5a, 5b, appeared better action coli comparably standard antibiotic.

Language: Английский

Citations

1
Preparation, characterization and study the biological activity for (six and seven) membered heterocyclic derivatives from 6-methoxy-2-amino benzo thiazole DOI Open Access

Adel Kareem Jasim,

Shaimaa Adnan

AIP conference proceedings, Journal Year: 2023, Volume and Issue: 2457, P. 030009 - 030009

Published: Jan. 1, 2023

Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Adel jasim, Shaimaa Adnan; Preparation, characterization study the biological activity for (six seven) membered heterocyclic derivatives from 6-methoxy-2-amino benzo thiazole. AIP Conference Proceedings 2 February 2023; 2457 (1): 030009. https://doi.org/10.1063/5.0118989 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Dropdown Menu input auto suggest filter your All ContentAIP Publishing PortfolioAIP Advanced |Citation

Language: Английский

Citations

0
Synthesis And Characterization ( Oxazepine , Thiazine and Quinazoline ) Derivatives And Study The Biological Activity As Antibacterial DOI Creative Commons

Adel Kareem Jasim,

Shaimaa Adnan

Al-Qadisiyah Journal Of Pure Science, Journal Year: 2021, Volume and Issue: 26(4), P. 364 - 379

Published: Aug. 15, 2021

This research. Included the preparation. and characterization some novel. Six seven membered Heterocyclic. Compounds ( oxazepine , thiazine quinazoline ) The first step in clode react 2-amino-6- methoxybenzothiazole with 4- amino acetophenone to get Schiff base derivative (1). second (1) 4 -hydroxy schiff (2) last involve Phthalic Maleic Succinic) anhydride .get derivatives (3,4and 5) also with(2-amino benzoic acid) (2-mercaptobenzoic acid (6)and (7) respectively .the physical; properties of prepared; These Compounds. Were Identification (FT-IR) ,(1H-NMR) (13C-NMR) by spectroscopy thene study their biological effect on two types bacteria Staphylococcus aureuses (Gram positive) Escherichia coli Negative)

Language: Английский

Citations

0