Synthesis of 2-(Pyridin-2-yl)phenols and 2-(Pyridin-2-yl)anilines

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(8), P. 5797 - 5810

Published: April 2, 2024

Herein, we report a new synthetic strategy for 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines catalyzed by Pd/C–ethylene system. The starting materials, 2-(pyridin-2-yl)cyclohexan-1-ones, can be easily prepared the reaction of substituted pyridine N-oxide cyclohexanones. most useful feature this method is that both are synthesized independently using same compound as material, simply adding or not nitrogen source.

Language: Английский

Hydroxylation of Substituted Anilides with Metallaphotocatalysis

ACS Omega, Journal Year: 2024, Volume and Issue: 9(18), P. 19982 - 19991

Published: April 24, 2024

We report the combination of organo-photocatalysis with transition metal (TM) catalysis for directed ortho-hydroxylation substituted anilides synthesis α-aminophenol derivatives under mild conditions. The developed metallaphotocatalysis utilizes N-pivaloyl as a directing group and phenyl iodine(III) bis(trifluoroacetate) (PIFA) in 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) photocatalyst [RuCl2(p-cymene)]2 TM catalyst visible-light irradiation at room temperature. hydroxylation reaction works well wide range substrates containing electron-withdrawing substituents could be applied to late-stage functionalization ortho-hydroxyl metabolite generation drug compounds-containing single reaction.

Language: Английский

Biomimetic design of an α-ketoacylphosphonium-based light-activated oxygenation auxiliary

Chemical Science, Journal Year: 2023, Volume and Issue: 14(38), P. 10488 - 10493

Published: Jan. 1, 2023

The biomimetic design of a transition metal complex based on the iron( iv )-oxo porphyrin π-cation radical species in cytochrome P450 enzymes has been studied extensively.

Language: Английский