Synthesis of Semaxanib-like 3-alkylideneoxindoles and their binding investigation with ctDNA by multiple methods
Journal of Molecular Liquids,
Journal Year:
2024,
Volume and Issue:
unknown, P. 126777 - 126777
Published: Dec. 1, 2024
Language: Английский
Five-membered ring systems: Pyrroles and benzo analogs
Progress in heterocyclic chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 123 - 173
Published: Jan. 1, 2024
Language: Английский
Diversity-Oriented Synthesis of Spirooxindoles via Asymmetric Organocatalytic Regiodivergent Cascade Reactions
Yong-Chao Ming,
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Xuejiao Lv,
No information about this author
Chen Wang
No information about this author
et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 5, 2024
A
regiodivergent
strategy
for
the
asymmetric
diversity-oriented
synthesis
of
spirooxindoles
via
organocatalytic
cascade
reactions
is
developed.
Two
regioselective
pathways
can
be
precisely
controlled
with
different
aminocatalysts
in
reaction
2-hydroxycinnamaldehydes
and
β,β-disubstituted
3-alkylidene
oxindoles.
The
vinylogous
Michael/oxa-Michael/aldol
gave
spiro-bridged
oxindoles
bearing
two
adjacent
quaternary
stereocenters,
while
oxa-Michael/Michael
spirooxindoles.
Moreover,
during
synthetic
application
studies,
an
acid-catalyzed
rearrangement
was
found
to
yield
biologically
important
Language: Английский