Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines

Beilstein Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 21, P. 915 - 925

Published: May 8, 2025

A silver(I) triflate-catalyzed post-Ugi assembly of novel pyrazolo[1,5- a ][1,4]diazepine scaffolds is reported offering high yields (up to 98%) under mild conditions. The synthetic sequence involves the Ugi four-component reaction (U4CR) pyrazole-3-carbaldehydes, primary amines, 3-substituted propiolic acids, and isocyanides, followed by intramolecular heteroannulation resulting pyrazole-tethered propargylamides occurring in 7- endo - dig fashion. approach scalable tolerates diverse range substitution patterns.

Language: Английский

Triflic-acid promoted post-Ugi condensation for the assembly of 2,6-diarylmorpholin-3-ones

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A two-step one-pot synthesis of 2,6-diarylmorpholin-3-ones involving Ugi reaction followed by a triflic acid-promoted intramolecular condensation accompanied loss the isocyanide-originated amide moiety is described.

Language: Английский