Synthesis of Carboranyl Alkyl Sulfide via Radical Thiol–Ene “Click” Reaction

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Synthetic methods that feature mild reaction conditions and broad functional group tolerance are highly desired for the development of third-generation boron delivery agents, which significant neutron capture therapy (BNCT), a selective cancer treatment technique. Molecules containing carborane promising candidates as compounds BNCT. Herein, we report an efficient radical thiol-ene "click" involving carboranyl thiols unactivated alkenes under photoredox conditions. This affords moderate to excellent isolated yields. The current methodology allows incorporation carborane, valuable moiety with high content, into molecules outstanding this method makes it suitable late-stage introduction bioactive molecules. addition reactivity thiol was investigated by DFT calculations uncover impact 3D aromaticity on stabilization sulfur centered radical.

Language: Английский

Preparation, sustained release and cell imaging studies of rhodamine 6G@-nido-carborane fluorescent polymer

Macromolecular Research, Journal Year: 2024, Volume and Issue: 32(6), P. 581 - 595

Published: April 24, 2024

Language: Английский

Pd-Catalysed synthesis of carborane sulfides from carborane thiols

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Carboranes are an interesting class of aromatic molecules with icosahedral geometry, high stability, and unique electronic effects.

Language: Английский