Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 17, 2025

Sepsis is a systemic inflammatory syndrome that can cause coagulation abnormalities, leading to damage in multiple organs. Vascular endothelial cells (VECs) are crucial the development of sepsis-induced coagulopathy (SIC). The role Parthenolide (PTL) regulating SIC by protecting VECs remains unclear. study utilized septic rats and lipopolysaccharide (LPS)-stimulated simulate model observe therapeutic effects PTL. Additionally, nanotechnology was employed produce Nano-PTL (N-PTL), whether it has advantages over PTL treating SIC. been shown mitigate lung injury rats, significantly reduce tumor necrosis factor-α (TNF-α) levels, increase survival rates. treatment also enhances function, augments vascular cell (VEC) reduces mitochondrial fragmentation, increases both oxygen consumption rate (OCR) membrane potential (MMP), while inhibiting reactive species (ROS) production. By increasing BRD4/BCL-xL prevent mitochondrial-mediated apoptosis VECs, improve VEC consequently ameliorate nanotechnology-synthesized N-PTL further protective on function. This clarifies mechanisms SIC, offering new strategies directions for sepsis.

Language: Английский

Identification of pyroptosis-related gene S100A12 as a potential diagnostic biomarker for sepsis through bioinformatics analysis and machine learning

Molecular Immunology, Journal Year: 2025, Volume and Issue: 183, P. 44 - 55

Published: May 2, 2025

Language: Английский

Alpha-1 antitrypsin targeted neutrophil elastase protects against sepsis-induced inflammation and coagulation in mice via inhibiting neutrophil extracellular trap formation

Life Sciences, Journal Year: 2024, Volume and Issue: 353, P. 122923 - 122923

Published: July 18, 2024

Language: Английский