Group 3 Innate Lymphoid Cells: A Potential Therapeutic Target for Steroid Resistant Asthma

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 68(1)

Published: Dec. 27, 2024

Asthma is a chronic airway inflammatory disease that affects millions globally. Although glucocorticoids are mainstay of asthma treatment, subset patients show resistance to these therapies, resulting in poor control and increased morbidity. The complex mechanisms underlying steroid-resistant (SRA) involve Th1 Th17 lymphocyte activity, neutrophil recruitment, NLRP3 inflammasome activation. Recent studies provided evidence innate lymphoid cells type 3 (ILC3s) might be potential therapeutic targets for non-eosinophilic (NEA) SRA. Like cells, ILC3s play crucial roles immune responses, inflammation, tissue homeostasis, contributing severity corticosteroid NEA. Biologics targeting ILC3-related pathways have shown promise managing Th2-low asthma, suggesting new avenues SRA treatment. This review aims explore the risk factors SRA, discuss challenges consolidate current findings on elucidate their role respiratory conditions. We present latest involvement human diseases development. Furthermore, we emerging biologics NEA highlights challenges, strategies, addresses significant gap research, with implications improving management asthma.

Language: Английский

1mΨ influences the performance of various positive-stranded RNA virus-based replicons

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Self-amplifying RNAs (saRNAs) are versatile vaccine platforms that take advantage of a viral RNA-dependent RNA polymerase (RdRp) to amplify the mRNA an antigen interest encoded within backbone genome once inside target cell. In recent years, more saRNA vaccines have been clinically tested with hope reducing vaccination dose compared conventional approach. The use N1-methyl-pseudouridine (1mY), which enhances stability and reduces innate immune response triggered by RNAs, is among improvements included in current vaccines. present study, we evaluated effects this modified nucleoside on various based different viruses. results showed stages replication process were affected depending virus. For TNCL, insect virus Alphanodavirus genus, was impaired poor recognition RdRp. contrast, translation step severely abrogated coxsackievirus B3 (CVB3), member Picornaviridae family. Finally, 1mΨ Semliki forest (SFV), not detrimental in vitro studies, but no advantages observed when immunogenicity vivo.

Language: Английский

Advances in Functional Organic-based Nanosystems for RNA Delivery, Targeting Different Organs

Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(2), P. 1 - 14

Published: Nov. 1, 2024

Language: Английский